2011
The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Wu X, Mintz GS, Xu K, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Dressler O, Parise H, Mehran R, Stone GW, Maehara A. The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2011, 4: 495-502. PMID: 21596321, DOI: 10.1016/j.jcin.2010.12.012.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary CirculationEuropeHumansLogistic ModelsMulticenter Studies as TopicMyocardial InfarctionNo-Reflow PhenomenonPlaque, AtheroscleroticPredictive Value of TestsRandomized Controlled Trials as TopicRetrospective StudiesRisk AssessmentRisk FactorsStentsStroke VolumeTreatment OutcomeUltrasonography, InterventionalUnited StatesVentricular Function, LeftConceptsAcute myocardial infarctionAttenuated plaqueHORIZONS-AMI trialPercutaneous coronary interventionMyocardial infarctionAttenuation scoreIntravascular ultrasoundVentricular ejection fractionGrayscale intravascular ultrasoundAngiographic thrombusFinal ThrombolysisCoronary interventionDistal embolizationEjection fractionMechanical obstructionTransient deteriorationCoronary flowStent implantationNo-ReflowPatientsMultivariate analysisLower baselineStent expansionInfarctionPlaquesIncidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial
Caixeta A, Dangas GD, Mehran R, Feit F, Nikolsky E, Lansky AJ, Aoki J, Moses JW, Steinhubl SR, White HD, Ohman EM, Manoukian SV, Fahy M, Stone GW. Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. American Heart Journal 2011, 161: 298-306.e1. PMID: 21315212, DOI: 10.1016/j.ahj.2010.10.035.Peer-Reviewed Original ResearchConceptsIIb/IIIa inhibitorsGP IIb/IIIa inhibitorsAcute coronary syndromeBivalirudin monotherapyMajor bleedingCoronary syndromePlatelet countClinical consequencesUrgent Intervention Triage Strategy (ACUITY) trialGlycoprotein IIb/IIIa inhibitorsPredictors of mortalityAcquired thrombocytopeniaACUITY trialAcute CatheterizationAntiplatelet medicationsAntithrombotic therapyIschemic complicationsAnticoagulant regimenIndependent predictorsStrategy trialThrombocytopeniaPatientsMultivariate analysisMonotherapyLess decline
2010
Impact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial)
Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Möckel M, Ochala A, Mehran R, Stone GW. Impact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial). The American Journal Of Cardiology 2010, 105: 1385-1394. PMID: 20451683, DOI: 10.1016/j.amjcard.2010.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaAngioplasty, Balloon, CoronaryCombined Modality TherapyDrug Therapy, CombinationElectrocardiographyFemaleFibrinolytic AgentsFollow-Up StudiesHeparinHirudinsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNeoadjuvant TherapyPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProbabilityProportional Hazards ModelsRecombinant ProteinsRisk AssessmentSex FactorsSurvival AnalysisThrombolytic TherapyTreatment OutcomeConceptsST-elevation myocardial infarctionElevation myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsBaseline anemiaPercutaneous coronary interventionAdjunctive antithrombotic therapyMajor bleedingMyocardial infarctionAntithrombotic therapyCoronary interventionUnfractionated heparinST-segment elevation myocardial infarctionMultivariate analysisAcute Myocardial Infarction trialImpact of anemiaMyocardial Infarction trialOutcomes of patientsHarmonizing OutcomesCardiac mortalityCause mortalityLate mortalityPrimary PCIClinical outcomes
2005
Low hematocrit predicts contrast-induced nephropathy after percutaneous coronary interventions
Nikolsky E, Mehran R, Lasic Z, Mintz GS, Lansky AJ, Na Y, Pocock S, Negoita M, Moussa I, Stone GW, Moses JW, Leon MB, Dangas G. Low hematocrit predicts contrast-induced nephropathy after percutaneous coronary interventions. Kidney International 2005, 67: 706-713. PMID: 15673320, DOI: 10.1111/j.1523-1755.2005.67131.x.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyPercutaneous coronary interventionBaseline hematocritCoronary interventionLow hematocritLower baseline hematocritChronic kidney diseaseGlomerular filtration rateImportant risk factorBaseline eGFRHematocrit dropLower eGFRConsecutive patientsIndependent predictorsKidney diseaseFiltration rateLowest quintileRisk factorsNephropathyPatientsHematocrit changesMultivariate analysisSignificant associationHematocrit valuesHematocrit
2004
Nonuniform Strut Distribution Correlates With More Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation
Takebayashi H, Mintz GS, Carlier S, Kobayashi Y, Fujii K, Yasuda T, Costa RA, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps E, Collins MB, Colombo A, Stone GW, Leon MB, Moses JW. Nonuniform Strut Distribution Correlates With More Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation. Circulation 2004, 110: 3430-3434. PMID: 15557367, DOI: 10.1161/01.cir.0000148371.53174.05.Peer-Reviewed Original ResearchConceptsMinimum lumen siteIntimal hyperplasiaLumen areaStent implantationStent strutsIH areaSmaller minimal lumen areaSirolimus-eluting stent implantationAmount of neointimaMinimum lumen areaMinimal lumen areaIVUS predictorsRestenosis patientsSES implantationRestenosis lesionsStent cellsStent strut distributionNeointimal hyperplasiaStrut distributionIntravascular ultrasoundMultivariate analysisVisible strutsComparison groupCross-sectional areaHyperplasia
2003
Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention.
Iakovou I, Dangas G, Mehran R, Lansky AJ, Ashby DT, Fahy M, Mintz GS, Kent KM, Pichard AD, Satler LF, Stone GW, Leon MB. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. Journal Of Invasive Cardiology 2003, 15: 18-22. PMID: 12499523.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyChronic renal failureOne-year mortalityIndependent predictorsPercutaneous interventionDiabetes mellitusClinical outcomesFemale genderMultivariate analysisOne-year clinical eventsNYHA IV classSevere heart failurePercutaneous coronary interventionImpact of genderCoronary interventionRenal failureHeart failureMale patientsCIN developmentClinical eventsPatientsMortalityMellitusNephropathySignificant gender differences
2001
Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devices
Dangas G, Mehran R, Kokolis S, Feldman D, Satler L, Pichard A, Kent K, Lansky A, Stone G, Leon M. Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devices. Journal Of The American College Of Cardiology 2001, 38: 638-641. PMID: 11527609, DOI: 10.1016/s0735-1097(01)01449-8.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionArteriotomy closure devicesManual compressionVascular complicationsCoronary interventionClosure deviceHigher vascular complication ratesVascular complication ratesVascular surgical repairPrevious clinical studiesAchievement of hemostasisHematocrit dropEarly ambulationComplication rateConsecutive patientsTransfemoral approachSheath removalSurgical repairArteriovenous fistulaHemostasis techniquesAccess siteClinical studiesLarge cohortMultivariate analysisComplicationsAre we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results. Journal Of The American College Of Cardiology 2001, 38: 150-154. PMID: 11451265, DOI: 10.1016/s0735-1097(01)01324-9.Peer-Reviewed Original ResearchConceptsLate cardiac eventsSVG lesionsCardiac eventsDistal embolizationStent useSaphenous vein graft angioplastyUnfavorable lesion characteristicsVein graft angioplastyOne-year outcomesProcedural success rateHigh procedural successHigh-risk lesionsGraft angioplastySVG angioplastyLate mortalityRepeat revascularizationBaseline characteristicsProcedural successRisk lesionsFavorable outcomeLesion characteristicsGraft treatmentMultivariate analysisAngioplastyLesions
2000
Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis
Waksman R, Bhargava B, Mintz G, Mehran R, Lansky A, Satler L, Pichard A, Kent K, Leon M. Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. Journal Of The American College Of Cardiology 2000, 36: 65-68. PMID: 10898414, DOI: 10.1016/s0735-1097(00)00681-1.Peer-Reviewed Original ResearchConceptsLate total occlusionPlacebo patientsStent restenosisIntracoronary radiationIrradiated groupAntiplatelet therapyTotal occlusionAcute myocardial infarctionEntire study groupUnstable anginaIntracoronary brachytherapyMyocardial infarctionRadiation protocolStudy groupLate thrombosisPatientsRestenosisMultivariate analysisMaximum doseMean timeNew stentTime of radiationVessel wallMonthsOverall rate
1999
Creatine Kinase-MB Enzyme Elevation Following Successful Saphenous Vein Graft Intervention Is Associated With Late Mortality
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Pichard A, Kent K, Satler L, Stone G, Leon M. Creatine Kinase-MB Enzyme Elevation Following Successful Saphenous Vein Graft Intervention Is Associated With Late Mortality. Circulation 1999, 100: 2400-2405. PMID: 10595951, DOI: 10.1161/01.cir.100.24.2400.Peer-Reviewed Original ResearchConceptsCK-MB elevationSaphenous vein graft interventionCK-MB riseVein graft interventionLate mortalityGraft interventionClinical eventsCreatine kinase‐MB enzyme elevationPeriprocedural CK-MB elevationNormal CK-MBMajor clinical eventsLate clinical eventsCreatine kinase elevationStrong independent predictorHospital complicationsSVG angioplastySVG interventionSVG lesionsConsecutive patientsDiabetes mellitusEnzyme elevationIndependent predictorsPrognostic significanceCK-MBMultivariate analysisAngiographic Patterns of In-Stent Restenosis
Mehran R, Dangas G, Abizaid A, Mintz G, Lansky A, Satler L, Pichard A, Kent K, Stone G, Leon M. Angiographic Patterns of In-Stent Restenosis. Circulation 1999, 100: 1872-1878. PMID: 10545431, DOI: 10.1161/01.cir.100.18.1872.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationRecurrent ISRAngiographic classificationStent restenosisSubsequent target vessel revascularizationClass IFinal diameter stenosisPattern IIPattern IVessel revascularizationAngiographic patternsISR lesionsIndependent predictorsDiameter stenosisPrognostic informationAngiographic presentationIntimal hyperplasiaPatient triageFocal lesionsIntravascular ultrasoundMultivariate analysisClass IIIPattern IVInvestigational purposesPattern III