2011
Frequency and Predictors of Stent Thrombosis After Percutaneous Coronary Intervention in Acute Myocardial Infarction
Dangas GD, Caixeta A, Mehran R, Parise H, Lansky AJ, Cristea E, Brodie BR, Witzenbichler B, Guagliumi G, Peruga JZ, Dudek D, Möeckel M, Stone GW. Frequency and Predictors of Stent Thrombosis After Percutaneous Coronary Intervention in Acute Myocardial Infarction. Circulation 2011, 123: 1745-1756. PMID: 21482968, DOI: 10.1161/circulationaha.110.981688.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAnticoagulantsAntithrombinsClopidogrelCoronary RestenosisCoronary ThrombosisDrug Therapy, CombinationDrug-Eluting StentsFemaleHeparinHirudinsHumansMaleMetalsMiddle AgedMyocardial InfarctionPaclitaxelPeptide FragmentsPlatelet Aggregation InhibitorsPredictive Value of TestsRecombinant ProteinsRisk FactorsTiclopidineTreatment OutcomeTubulin ModulatorsConceptsGlycoprotein IIb/IIIa inhibitorsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionBare metal stentsDrug-eluting stentsStent thrombosisCoronary interventionMyocardial infarctionMetal stentsBivalirudin monotherapyOnly bare-metal stentsAcute Myocardial Infarction trialIIb/IIIa inhibitorsClopidogrel loading dosePotent antiplatelet therapyProbable stent thrombosisAcute stent thrombosisMyocardial Infarction trialAcute myocardial infarctionAntithrombin therapyHarmonizing OutcomesAntiplatelet therapyIndependent predictorsFIVE-YEAR FOLLOW-UP OF POLYTETRAFLUOROETHYLENE-COVERED STENTS COMPARED WITH BARE METAL STENTS IN AORTOCORONARY SAPHENOUS VEIN GRAFTS: THE RANDOMIZED BARRICADE TRIAL
Genereux P, Goldberg S, O'Shaughnessy C, Midei M, Siegel R, Mintz G, Cristea E, Dangas G, Lansky A, Mehran R, Stone G. FIVE-YEAR FOLLOW-UP OF POLYTETRAFLUOROETHYLENE-COVERED STENTS COMPARED WITH BARE METAL STENTS IN AORTOCORONARY SAPHENOUS VEIN GRAFTS: THE RANDOMIZED BARRICADE TRIAL. Journal Of The American College Of Cardiology 2011, 57: e1621. DOI: 10.1016/s0735-1097(11)61621-5.Peer-Reviewed Original ResearchPaclitaxel-Eluting Stents Compared With Bare Metal Stents in Diabetic Patients With Acute Myocardial Infarction
Witzenbichler B, Wöhrle J, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Hood KL, Parise H, Lansky AJ, Nikolsky E, Mehran R, Stone GW. Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Diabetic Patients With Acute Myocardial Infarction. Circulation Cardiovascular Interventions 2011, 4: 130-138. PMID: 21364152, DOI: 10.1161/circinterventions.110.960245.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPaclitaxel-eluting stentsTarget lesion revascularizationBare metal stentsHORIZONS-AMI trialDiabetic patientsDiabetes mellitusStent thrombosisMyocardial infarctionPercutaneous interventionIschemia-driven target lesion revascularizationMetal stentsAcute Myocardial Infarction trialHigh-risk diabetic patientsMyocardial Infarction trialPrimary percutaneous interventionInsulin-treated diabetesAcute myocardial infarctionAngiographic late lossComparable safety outcomesBinary restenosisHarmonizing OutcomesLesion revascularizationNondiabetic patientsAngiographic restenosisStrut Coverage and Late Malapposition With Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Acute Myocardial Infarction
Guagliumi G, Costa MA, Sirbu V, Musumeci G, Bezerra HG, Suzuki N, Matiashvili A, Lortkipanidze N, Mihalcsik L, Trivisonno A, Valsecchi O, Mintz GS, Dressler O, Parise H, Maehara A, Cristea E, Lansky AJ, Mehran R, Stone GW. Strut Coverage and Late Malapposition With Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Acute Myocardial Infarction. Circulation 2011, 123: 274-281. PMID: 21220730, DOI: 10.1161/circulationaha.110.963181.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPaclitaxel-eluting stentsBare metal stentsOptical coherence tomographyStrut coverageCoherence tomographyBMS lesionsMyocardial infarctionPE lesionsStent strutsMetal stentsPrimary percutaneous coronary interventionAcute Myocardial Infarction trialMyocardial Infarction trialPrespecified end pointElevation myocardial infarctionIndependent core laboratoryPercutaneous coronary interventionStent strut coverageAcute myocardial infarctionSubsequent stent thrombosisDrug-eluting stentsFormal substudyHarmonizing OutcomesStent assignment
2010
IMPACT OF PACLITAXEL-ELUTING STENTS IN PATIENTS WITH ANTERIOR MYOCARDIAL INFARCTION UNDERGOING PRIMARY ANGIOPLASTY COMPARED WITH BARE METAL STENTS: ANALYSIS FROM THE HORIZONS AMI TRIAL
Wöhrle J, Witzenbichler B, Gualiumi G, Brodie B, Dudek D, Kornowski R, Hartmann F, Paris H, Lansky A, Moore C, Mehran R, Stone G. IMPACT OF PACLITAXEL-ELUTING STENTS IN PATIENTS WITH ANTERIOR MYOCARDIAL INFARCTION UNDERGOING PRIMARY ANGIOPLASTY COMPARED WITH BARE METAL STENTS: ANALYSIS FROM THE HORIZONS AMI TRIAL. Journal Of The American College Of Cardiology 2010, 55: a183.e1711. DOI: 10.1016/s0735-1097(10)61712-3.Peer-Reviewed Original Research
2009
Volumetric Intravascular Ultrasound Analysis of Paclitaxel-Eluting and Bare Metal Stents in Acute Myocardial Infarction
Maehara A, Mintz GS, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Parise H, Mehran R, Stone GW. Volumetric Intravascular Ultrasound Analysis of Paclitaxel-Eluting and Bare Metal Stents in Acute Myocardial Infarction. Circulation 2009, 120: 1875-1882. PMID: 19858413, DOI: 10.1161/circulationaha.109.873893.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPaclitaxel-eluting stentsBare metal stentsElevation myocardial infarctionPositive vessel remodelingMyocardial infarctionVolume obstructionStent malappositionMetal stentsAcute Myocardial Infarction trialVessel remodelingVolumetric intravascular ultrasound analysisIntravascular ultrasound substudyMyocardial Infarction trialPrespecified end pointAcute myocardial infarctionBlinded core laboratoryNew aneurysm formationIntravascular ultrasound analysisMedian stent lengthDrug-eluting stentsPaclitaxel-ElutingThrombus protrusionUltrasound substudySymptom onsetSafety and Efficacy of Drug-Eluting and Bare Metal Stents
Kirtane AJ, Gupta A, Iyengar S, Moses JW, Leon MB, Applegate R, Brodie B, Hannan E, Harjai K, Jensen LO, Park SJ, Perry R, Racz M, Saia F, Tu JV, Waksman R, Lansky AJ, Mehran R, Stone GW. Safety and Efficacy of Drug-Eluting and Bare Metal Stents. Circulation 2009, 119: 3198-3206. PMID: 19528338, DOI: 10.1161/circulationaha.108.826479.Peer-Reviewed Original ResearchConceptsBare metal stentsDrug-eluting stentsTarget vessel revascularizationMyocardial infarctionVessel revascularizationObservational studyMetal stentsEfficacy end pointTotal patientsOverall mortalityDrug-ElutingDES useLabel indicationsLabel useResidual confoundingBMS useRCTsPatientsDrug AdministrationInfarctionRevascularizationEnd pointMortality dataComparable reductionStentsClassification and Potential Mechanisms of Intravascular Ultrasound Patterns of Stent Fracture
Doi H, Maehara A, Mintz GS, Tsujita K, Kubo T, Castellanos C, Liu J, Yang J, Oviedo C, Aoki J, Franklin-Bond T, Dasgupta N, Lansky AJ, Dangas GD, Stone GW, Moses JW, Mehran R, Leon MB. Classification and Potential Mechanisms of Intravascular Ultrasound Patterns of Stent Fracture. The American Journal Of Cardiology 2009, 103: 818-823. PMID: 19268738, DOI: 10.1016/j.amjcard.2008.11.051.Peer-Reviewed Original ResearchConceptsStent fractureStent failureIndex stentingDrug-eluting stent (DES) failurePaclitaxel-eluting Taxus stentSirolimus-eluting Cypher stentsIntravascular ultrasound findingsBare metal stentsComplete stent fractureCoronary aneurysmsClinical eventsFracture groupTaxus stentUltrasound findingsUltrasound patternAneurysm formationIVUS analysisMetal stentsSimilar clinical eventsCypher stentsAneurysmsStent segmentIVUSPotential mechanismsStentsEarly Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Drug-Eluting and Bare Metal Stents
Aoki J, Lansky AJ, Mehran R, Moses J, Bertrand ME, McLaurin BT, Cox DA, Lincoff AM, Ohman EM, White HD, Parise H, Leon MB, Stone GW. Early Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Drug-Eluting and Bare Metal Stents. Circulation 2009, 119: 687-698. PMID: 19171852, DOI: 10.1161/circulationaha.108.804203.Peer-Reviewed Original ResearchConceptsIIb/IIIa inhibitorsAcute coronary syndromeGlycoprotein IIb/IIIa inhibitorsEarly stent thrombosisStent thrombosisCoronary syndromeBare metal stentsDrug-eluting stentsThienopyridine administrationAngiographic resultsHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialMetal stentsHigher baseline hemoglobin levelsInsulin-requiring diabetes mellitusQuantitative coronary angiographic analysisStent minimal lumen diameterAntiplatelet drug useBaseline renal insufficiencyCoronary angiographic analysisSuboptimal angiographic resultsBaseline hemoglobin levelDefinite stent thrombosisProbable stent thrombosisHigh-risk patients
2006
The randomised study of the double dose versus single dose sirolimus-eluting stent for the treatment of diabetic patients with de novo coronary lesions.
Costa RA, Sousa JE, Abizaid A, Chaves A, Feres F, Sousa AG, Musumeci G, Mehran R, Fitzgerald PJ, Lansky AJ, Leon MB, Shiran A, Halon DA, Lewis BS, Guagliumi G. The randomised study of the double dose versus single dose sirolimus-eluting stent for the treatment of diabetic patients with de novo coronary lesions. EuroIntervention 2006, 2: 295-301. PMID: 19755304.Peer-Reviewed Original ResearchDe novo coronary lesionsSirolimus-eluting stentsNovo coronary lesionsDiabetic patientsCoronary lesionsDouble doseRevascularisation ratesStent late lumen lossLesion revascularisation rateDouble-blind fashionLate lumen lossBare metal stentsIncomplete stent appositionBinary restenosisPrimary endpointStent thrombosisLumen lossLate thrombosesNeointimal proliferationProcedure successNeointimal volumeNeointimal hyperplasiaPatientsMetal stentsBlind fashionEffect of Everolimus-Eluting Stents in Different Vessel Sizes (from the Pooled FUTURE I and II Trials)
Tsuchiya Y, Lansky AJ, Costa RA, Mehran R, Pietras C, Shimada Y, Sonoda S, Cristea E, Negoita M, Dangas GD, Moses JW, Leon MB, Fitzgerald PJ, Müller R, Störger H, Hauptmann KE, Grube E. Effect of Everolimus-Eluting Stents in Different Vessel Sizes (from the Pooled FUTURE I and II Trials). The American Journal Of Cardiology 2006, 98: 464-469. PMID: 16893698, DOI: 10.1016/j.amjcard.2006.02.054.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood Vessel Prosthesis ImplantationCoated Materials, BiocompatibleCoronary AngiographyCoronary RestenosisCoronary VesselsEverolimusFemaleFollow-Up StudiesHumansImmunosuppressive AgentsMaleMiddle AgedProspective StudiesProsthesis DesignSirolimusStentsTreatment OutcomeUltrasonography, InterventionalConceptsBare metal stentsDe novo coronary lesionsNovo coronary lesionsCoronary lesionsNeointimal proliferationStent late lumen lossMid-term outcomesLate lumen lossEverolimus-Eluting StentsQuantitative coronary angiographyMinimum lumen areaVessel sizeII trialCoronary angiographyI trialIncomplete appositionLumen lossStent thrombosisAneurysm formationStent restenosisIntravascular ultrasoundMetal stentsReference diameterLumen areaPatients
2002
7-Hexanoyltaxol–Eluting Stent for Prevention of Neointimal Growth
Kataoka T, Grube E, Honda Y, Morino Y, Hur SH, Bonneau HN, Colombo A, Di Mario C, Guagliumi G, Hauptmann KE, Pitney MR, Lansky AJ, Stertzer SH, Yock PG, Fitzgerald PJ. 7-Hexanoyltaxol–Eluting Stent for Prevention of Neointimal Growth. Circulation 2002, 106: 1788-1793. PMID: 12356631, DOI: 10.1161/01.cir.0000031734.11420.1c.Peer-Reviewed Original ResearchConceptsBare metal stentsNeointimal growthIntravascular ultrasoundDe novo coronary lesionsAdjacent reference segmentsNovo coronary lesionsIndependent core laboratoryHuman feasibility studyNeointimal tissue growthIVUS substudyUnhealed dissectionConventional mechanical treatmentMulticenter trialCoronary lesionsRestenosis rateAtherosclerotic diseaseIntracoronary brachytherapyIVUS analysisNeointimal responseLong-term benefitsNeointimal thickeningStented segmentsCore laboratoryMetal stentsReference segments