2011
Impact of In-Hospital Major Bleeding on Late Clinical Outcomes After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Suh JW, Mehran R, Claessen BE, Xu K, Baber U, Dangas G, Parise H, Lansky AJ, Witzenbichler B, Grines CL, Guagliumi G, Kornowski R, Wöhrle J, Dudek D, Weisz G, Stone GW. Impact of In-Hospital Major Bleeding on Late Clinical Outcomes After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2011, 58: 1750-1756. PMID: 21996385, DOI: 10.1016/j.jacc.2011.07.021.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIMajor adverse cardiovascular eventsHORIZONS-AMI trialAdverse cardiovascular eventsPercutaneous coronary interventionLong-term prognosisMajor bleedingMyocardial infarctionCardiovascular eventsCoronary interventionNon-coronary artery bypass graft-related major bleedingST-segment elevation myocardial infarctionST-segment myocardial infarctionHospital major bleedingLate clinical outcomesElevation myocardial infarctionAcute myocardial infarctionIndependent predictorsMedication useClinical outcomesPatientsBleedingHigh mortalityInfarction
2009
Impact of Gender and Antithrombin Strategy on Early and Late Clinical Outcomes in Patients With Non–ST-Elevation Acute Coronary Syndromes (from the ACUITY Trial)
Lansky AJ, Mehran R, Cristea E, Parise H, Feit F, Ohman EM, White HD, Alexander KP, Bertrand ME, Desmet W, Hamon M, Stone GW. Impact of Gender and Antithrombin Strategy on Early and Late Clinical Outcomes in Patients With Non–ST-Elevation Acute Coronary Syndromes (from the ACUITY Trial). The American Journal Of Cardiology 2009, 103: 1196-1203. PMID: 19406258, DOI: 10.1016/j.amjcard.2009.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAnticoagulantsAntithrombinsCause of DeathDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationElectrocardiographyEnoxaparinFemaleFollow-Up StudiesHeparinHirudinsHumansMaleMiddle AgedPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProbabilityProportional Hazards ModelsRecombinant ProteinsReference ValuesRisk AssessmentSeverity of Illness IndexSex FactorsSurvival AnalysisTime FactorsTreatment OutcomeConceptsGlycoprotein IIb/IIIa inhibitorsElevation acute coronary syndromePercutaneous coronary interventionAcute coronary syndromeComposite ischemiaNet clinical outcomeMajor bleedingCoronary syndromeClinical outcomesNet clinical adverse eventsIIb/IIIa inhibitorsLate clinical outcomesCoronary artery bypassClinical adverse eventsImpact of genderACUITY trialBivalirudin monotherapyAntithrombotic therapyArtery bypassNon–STAdverse eventsAntithrombotic strategiesCoronary interventionIschemiaBivalirudin
2002
New-Device Angioplasty in Women: Clinical Outcome and Predictors in a 7,372-Patient Registry
Lansky AJ, Mehran R, Dangas G, Desai K, Costantini-Ortiz C, Cristea E, New G, Negoita M, Stone GW, Leon MB. New-Device Angioplasty in Women: Clinical Outcome and Predictors in a 7,372-Patient Registry. Epidemiology 2002, 13: s46-s51. PMID: 12071484, DOI: 10.1097/00001648-200205001-00010.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsNew device angioplastyClinical outcomesFemale genderHospital mortalityLate mortalityIndependent predictorsMortality rateHospital major adverse cardiac eventsIschemic coronary artery diseaseLong-term clinical outcomesSaphenous vein graft lesionsMultivariable logistic regression analysisDevice-specific outcomesHospital cardiac mortalityLate clinical outcomesAdverse cardiac eventsComorbid risk factorsCongestive heart failureNative coronary arteriesOutcomes of womenVein graft lesionsCoronary artery diseaseReference vessel sizeConventional balloon angioplastyDevice selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials)
Ajani AE, Waksman R, Zimarino M, Kim H, Pichard AD, Satler LF, Kent KM, White RL, Pinnow E, Mehran R, Lansky A, Lindsay J. Device selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials). The American Journal Of Cardiology 2002, 89: 137-144. PMID: 11792331, DOI: 10.1016/s0002-9149(01)02189-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplastyAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary DiseaseDose-Response Relationship, RadiationFemaleHumansIridium RadioisotopesLogistic ModelsMaleMiddle AgedProspective StudiesRisk FactorsSecondary PreventionStentsTreatment OutcomeVascular PatencyConceptsExcimer laser coronary angioplastyMajor adverse coronary eventsAdditional stent implantationTreatment of ISRRecurrence rateCoronary angioplastyRotational atherectomyStent implantationStent restenosisBalloon percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyIntracoronary gamma radiationLate clinical outcomesAdverse coronary eventsOverall recurrence rateTransluminal coronary angioplastyLaser coronary angioplastyHigh recurrence rateUse of stentingDevice selectionAngiographic characteristicsMACE ratePlacebo groupPlacebo therapyCoronary events
2001
Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting
Ahmed J, Dangas G, Lansky A, Mehran R, Hong M, Mintz G, Pichard A, Satler L, Kent K, Stone G, Leon M. Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting. The American Journal Of Cardiology 2001, 87: 401-405. PMID: 11179522, DOI: 10.1016/s0002-9149(00)01391-6.Peer-Reviewed Original ResearchConceptsAcute renal failureClinical outcomesSVG lesionsHospital mortalityVascular complicationsRenal failureProcedural successStent implantationFemale genderOne-year clinical outcomesSaphenous vein graft stentingLate clinical outcomesOverall procedural successSaphenous vein graftsVentricular ejection fractionInfluence of genderMultivariate regression analysisGraft stentingLesion revascularizationCoronary revascularizationConsecutive patientsDiabetes mellitusEjection fractionHospital eventsVein grafts
2000
Comparison of debulking followed by stenting versus stenting alone for saphenous vein graft aortoostial lesions: immediate and one-year clinical outcomes
Ahmed J, Hong M, Mehran R, Mintz G, Lansky A, Pichard A, Satler L, Kent K, Wu H, Stone G, Leon M. Comparison of debulking followed by stenting versus stenting alone for saphenous vein graft aortoostial lesions: immediate and one-year clinical outcomes. Journal Of The American College Of Cardiology 2000, 35: 1560-1568. PMID: 10807461, DOI: 10.1016/s0735-1097(00)00592-1.Peer-Reviewed Original ResearchConceptsOne-year clinical outcomesLumen cross-sectional areaLate clinical outcomesClinical outcomesStent implantationProcedural successRestenotic lesionsIntravascular ultrasoundCross-sectional areaOverall cardiac event-free survivalCardiac event-free survivalLate cardiac eventsEvent-free survivalOverall procedural successCox regression analysisComplex lesion subsetsPalmaz-Schatz stentsLesion revascularizationCardiac eventsMost patientsConsecutive patientsIndependent predictorsProcedural complicationsLesion subsetsMyocardial infarctionLong-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting
Saucedo J, Mehran R, Dangas G, Hong M, Lansky A, Kent K, Satler L, Pichard A, Stone G, Leon M. Long-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting. Journal Of The American College Of Cardiology 2000, 35: 1134-1141. PMID: 10758952, DOI: 10.1016/s0735-1097(00)00513-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplasty, Balloon, CoronaryBiomarkersCoronary DiseaseCreatine KinaseDisease-Free SurvivalFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesPulmonary EdemaRadiographyRecurrenceRisk FactorsSeverity of Illness IndexStentsTreatment OutcomeConceptsCK-MB elevationCreatine kinase-myocardial band isoenzyme (CK-MB) elevationMajor adverse clinical eventsCK-MB riseAdverse clinical eventsCoronary stentingLate mortalityClinical eventsGroup 1Group 3Group 2Long-term clinical importanceLong-term clinical eventsHospital recurrent ischemiaLate clinical outcomesCardiac enzyme elevationEvent-free survivalClinical end pointsHigher late mortalityPercutaneous coronary interventionPercutaneous coronary revascularizationCK-MB levelsNative coronary arteriesSuccessful coronary stentingSuccessful stent implantationProcedural results and late clinical outcomes after percutaneous interventions using long (≥25 mm) versus short (<20 mm) stents
Kornowski R, Bhargava B, Fuchs D, Lansky A, Satler L, Pichard A, Hong M, Kent K, Mehran R, Stone G, Leon M. Procedural results and late clinical outcomes after percutaneous interventions using long (≥25 mm) versus short (<20 mm) stents. Journal Of The American College Of Cardiology 2000, 35: 612-618. PMID: 10716462, DOI: 10.1016/s0735-1097(99)00580-x.Peer-Reviewed Original ResearchConceptsShort stent groupsPeriprocedural non-Q-wave myocardial infarctionNon-Q-wave myocardial infarctionCardiac event-free survivalEvent-free survivalMyocardial infarctionClinical outcomesProcedural successStent groupShort stentsHospital complicationsLesion revascularizationLong stentsOverall cardiac event-free survivalLong-term clinical outcomesQ-wave myocardial infarctionLate clinical outcomesLong stent implantationsMajor procedural complicationsMean stent lengthMore diffuse lesionsSingle-vessel interventionVessel revascularization rateOverall procedural successLong-term outcomesEffect of plaque debulking and stenting on short- and long-term outcomes after revascularization of chronic total occlusions
Gruberg L, Mehran R, Dangas G, Hong M, Mintz G, Kornowski R, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Effect of plaque debulking and stenting on short- and long-term outcomes after revascularization of chronic total occlusions. Journal Of The American College Of Cardiology 2000, 35: 151-156. PMID: 10636273, DOI: 10.1016/s0735-1097(99)00491-x.Peer-Reviewed Original ResearchConceptsLesion revascularization rateChronic total occlusionRevascularization ratesClinical outcomesTotal occlusionCoronary arteryStent deploymentTarget lesion revascularization rateLong-term clinical outcomesCoronary artery locationLate clinical outcomesPrimary success rateNative coronary arteriesGroup of patientsCoronary artery occlusionLong-term outcomesSuccessful stent deploymentNew interventional devicesEffect of plaqueAngioplasty ratesHospital mortalityLesion modificationSuccessful stentingAngiographic characteristicsHospital outcomes
1998
Procedural Results and Late Clinical Outcomes After Placement of Three or More Stents in Single Coronary Lesions
Kornowski R, Mehran R, Hong M, Satler L, Pichard A, Kent K, Mintz G, Waksman R, Laird J, Lansky A, Bucher T, Popma J, Leon M. Procedural Results and Late Clinical Outcomes After Placement of Three or More Stents in Single Coronary Lesions. Circulation 1998, 97: 1355-1361. PMID: 9577946, DOI: 10.1161/01.cir.97.14.1355.Peer-Reviewed Original ResearchConceptsNon-Q-wave MIUnfavorable lesion characteristicsClinical outcomesProcedural successMajor complicationsLesion characteristicsMultiple stentsOverall cardiac event-free survivalMajor cardiac event rateCardiac event-free survivalLong-term clinical outcomesCardiac event rateHospital procedural successLate clinical outcomesSingle coronary lesionsEvent-free survivalSaphenous vein graftsOverall procedural successRight coronary arteryLong-term complicationsQ-wave MILesion revascularizationConsecutive patientsCoronary lesionsLong dissection