2014
Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”
Majidi M, Kosinski AS, Al-Khatib SM, Smolders L, Cristea E, Lansky AJ, Stone GW, Mehran R, Gibbons RJ, Crijns HJ, Wellens HJ, Gorgels AP, Krucoff MW. Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”. European Heart Journal Acute Cardiovascular Care 2014, 4: 51-59. PMID: 25063574, DOI: 10.1177/2048872614532414.Peer-Reviewed Original ResearchConceptsST-segment recoveryMyocardial blush gradeST-segment elevation myocardial infarctionNormal epicardial flowTIMI 3 flowPercutaneous coronary interventionEpicardial flowLarger ISOptimal reperfusionVentricular arrhythmiasMyocellular injuryFinal TIMI 3 flowMyocardial Infarction 3 flowAnterior STEMI patientsElevation myocardial infarctionReperfusion ventricular arrhythmiasInfarct size assessmentMyocardial infarction reperfusionContinuous ECG monitoringMBG 2/3Myocardial ISBlush gradeSTEMI patientsCoronary interventionMyocardial reperfusion
2011
Relationship between angiographic dynamic and densitometric assessment of myocardial reperfusion and survival in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: The Harmonizing Outcomes with Revascularization and Stents in AMI (HORIZONS-AMI) trial
Brener SJ, Cristea E, Mehran R, Dressler O, Lansky AJ, Stone GW. Relationship between angiographic dynamic and densitometric assessment of myocardial reperfusion and survival in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: The Harmonizing Outcomes with Revascularization and Stents in AMI (HORIZONS-AMI) trial. American Heart Journal 2011, 162: 1044-1051. PMID: 22137078, DOI: 10.1016/j.ahj.2011.08.022.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionIndependent predictorsMyocardial infarctionMyocardial perfusionHORIZONS-AMI studyEarly clinical outcomesLong-term mortalityElevation myocardial infarctionAcute myocardial infarctionHarmonizing OutcomesLate mortalityAMI trialEpicardial flowMyocardial reperfusionClinical outcomesGrade 2/3Multivariable analysisLate survivalPatientsMortalityTime pointsDensitometric assessment
2009
Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial.
Nikolsky E, Stone GW, Lee E, Lansky AJ, Webb J, Cox DA, Brodie BR, Turco MA, Rutherford BD, Kalynych AM, Antoniucci D, Krucoff MW, Gibbons RJ, Fahy M, Mehran R. Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial. EuroIntervention 2009, 5: 417-24. PMID: 19755327, DOI: 10.4244/eijv5i4a66.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplastyAngioplasty, Balloon, CoronaryBlood PressureBradycardiaFemaleHumansMaleMiddle AgedMulticenter Studies as TopicMyocardial InfarctionPostoperative ComplicationsRandomized Controlled Trials as TopicStentsSurvival AnalysisSurvivorsTachycardiaTreatment FailureTreatment OutcomeConceptsAcute myocardial infarctionMicrovascular reperfusionInfarct sizeClinical outcomesMyocardial infarctionEMERALD trialLAD infarctsDistal protectionGrade 3Final TIMI flow grade 3Myocardial blush grade 3Non-anterior myocardial infarctionTIMI flow grade 3ST-segment resolutionEvent-free survivalInfarct-related arteryLarger infarct sizeSevere heart failureRate of reperfusionRescue angioplastyCulprit vesselPrimary PCIReperfusion successEpicardial flowHeart failure