2022
Development and validation of an automated algorithm for end point adjudication for a large U.S. national registry
Friedman DJ, Pierre D, Wang Y, Gambone L, Koutras C, Segawa C, Farb A, Vemulapalli S, Varosy PD, Masoudi FA, Lansky A, Curtis JP, Freeman JV. Development and validation of an automated algorithm for end point adjudication for a large U.S. national registry. American Heart Journal 2022, 254: 102-111. PMID: 36007567, DOI: 10.1016/j.ahj.2022.08.006.Peer-Reviewed Original ResearchConceptsEnd point adjudicationCEC adjudicationEnd pointLarge registriesClinical trialsNational Cardiovascular Data RegistryMajor vascular complicationsU.S. National RegistryPost-discharge eventsAgreement rateMajor bleedingNeurologic eventsVascular complicationsNational registryEvent adjudicationData registryRegistryCommittee's evaluationsPercent agreementGold standardAgreement thresholdHospitalTrialsFurther confirmationBleeding
2013
ASSOCIATION BETWEEN CORONARY CALCIFICATION AND BLEEDING AFTER PCI IN ACS: POOLED ANALYSIS FROM HORIZONS-AMI AND ACUITY TRIALS
Genereux P, Maehara A, Kirtane A, Brener S, Palmerini T, Lasalle L, Sanidas E, Tarigopula M, Yadav M, McAndrew T, Fahy M, Lansky A, Mehran R, Mintz G, Stone G. ASSOCIATION BETWEEN CORONARY CALCIFICATION AND BLEEDING AFTER PCI IN ACS: POOLED ANALYSIS FROM HORIZONS-AMI AND ACUITY TRIALS. Journal Of The American College Of Cardiology 2013, 61: e143. DOI: 10.1016/s0735-1097(13)60144-8.Peer-Reviewed Original Research
2011
Impact of In-Hospital Major Bleeding on Late Clinical Outcomes After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Suh JW, Mehran R, Claessen BE, Xu K, Baber U, Dangas G, Parise H, Lansky AJ, Witzenbichler B, Grines CL, Guagliumi G, Kornowski R, Wöhrle J, Dudek D, Weisz G, Stone GW. Impact of In-Hospital Major Bleeding on Late Clinical Outcomes After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction The HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2011, 58: 1750-1756. PMID: 21996385, DOI: 10.1016/j.jacc.2011.07.021.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIMajor adverse cardiovascular eventsHORIZONS-AMI trialAdverse cardiovascular eventsPercutaneous coronary interventionLong-term prognosisMajor bleedingMyocardial infarctionCardiovascular eventsCoronary interventionNon-coronary artery bypass graft-related major bleedingST-segment elevation myocardial infarctionST-segment myocardial infarctionHospital major bleedingLate clinical outcomesElevation myocardial infarctionAcute myocardial infarctionIndependent predictorsMedication useClinical outcomesPatientsBleedingHigh mortalityInfarction
2009
Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial
Mehran R, Pocock SJ, Stone GW, Clayton TC, Dangas GD, Feit F, Manoukian SV, Nikolsky E, Lansky AJ, Kirtane A, White HD, Colombo A, Ware JH, Moses JW, Ohman EM. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. European Heart Journal 2009, 30: 1457-1466. PMID: 19351691, PMCID: PMC2695951, DOI: 10.1093/eurheartj/ehp110.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeMajor bleedingMyocardial infarctionBaseline predictorsMortality riskMajor bleedsCoronary syndromeHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialElevation acute coronary syndromeMultivariable Cox regression modelsDays of randomizationTime-updated covariatesRecurrent myocardial infarctionIndependent baseline predictorsCox regression modelShort-term riskTiming of mortalityACUITY trialAcute CatheterizationHazard ratioStrategy trialBleedingMortality hazardCox model
2007
Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial
Stone GW, White HD, Ohman EM, Bertrand ME, Lincoff AM, McLaurin BT, Cox DA, Pocock SJ, Ware JH, Feit F, Colombo A, Manoukian SV, Lansky AJ, Mehran R, Moses JW, investigators F. Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. The Lancet 2007, 369: 907-919. PMID: 17368152, DOI: 10.1016/s0140-6736(07)60450-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryAnticoagulantsCombined Modality TherapyDrug Therapy, CombinationEnoxaparinFemaleHeparinHirudinsHumansMaleMiddle AgedMyocardial IschemiaPeptide FragmentsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecombinant ProteinsTreatment OutcomeConceptsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsPercutaneous coronary interventionAcute coronary syndromeNet clinical outcomeHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialCoronary interventionClinical outcomesMajor bleedingCoronary syndromeAcute CatheterizationStrategy trialDirect thrombin inhibitor bivalirudinAdverse ischemic eventsMajor haemorrhagic complicationsComparable clinical outcomesThrombin inhibitor bivalirudinHaemorrhagic complicationsIschemic eventsUnfractionated heparinSubgroup analysisProportion of individualsBivalirudinBleeding