2022
Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders
Bernhisel A, Siddon A, Katz S. Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders. American Journal Of Clinical Pathology 2022, 158: s105-s105. DOI: 10.1093/ajcp/aqac126.221.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaIRF4 rearrangementB cellsCD30-positive T-cell lymphoproliferative disordersT-cell lymphoproliferative disorderLarge B-cell lymphomaPast medical historyT-cell lesionsCell lymphoproliferative disordersT-cell disordersB-cell lymphomaT-cell neoplasmsT cell linesIRF4 gene rearrangementT cell developmentLymphomatoid papulosisHodgkin's diseaseHematopoietic progenitor cellsLymphoproliferative disordersIntroduction/ObjectiveCase reportMedical historyCommon lymphoid progenitorsCell lesionsCell neoplasms
2020
Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status
Balbuena-Merle R, Santhanakrishnan M, Devine L, Gibb DR, Tormey CA, Siddon AJ, Curtis SA, Gallagher PG, Weinstein JS, Hendrickson JE. Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status. Transfusion And Apheresis Science 2020, 59: 102778. PMID: 32439490, PMCID: PMC7483805, DOI: 10.1016/j.transci.2020.102778.Peer-Reviewed Original ResearchConceptsTfh-like cellsNaïve CD4 T cellsSickle cell diseaseCD4 T cellsCD4 T cell subsetsT cell subsetsT cellsCell diseaseRed blood cell alloimmunizationPeripheral blood mononuclear cellsBlood mononuclear cellsCD3/CD28Electronic medical recordsAlloimmunization statusHLA alloantibodiesRBC autoantibodiesRBC alloantibodiesFollicular helperIL-12Mononuclear cellsMedical recordsIL-7Antigen specificityB cellsAlloantibodies
2018
False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab
Chen PP, Tormey CA, Eisenbarth SC, Torres R, Richardson SS, Rinder HM, Smith BR, Siddon AJ. False-Positive Light Chain Clonal Restriction by Flow Cytometry in Patients Treated With Alemtuzumab. American Journal Of Clinical Pathology 2018, 151: 154-163. PMID: 30307483, DOI: 10.1093/ajcp/aqy129.Peer-Reviewed Original ResearchConceptsHealthy donor bloodAlemtuzumab treatmentDonor bloodBone marrowFlow cytometryLight chain restrictionT-cell prolymphocytic leukemiaB-cell neoplasmsLight chain clonalityFlow cytometry analysisAutoimmune diseasesHematologic malignanciesImmunophenotypic analysisChain restrictionAlemtuzumabT cellsB cellsProlymphocytic leukemiaImmunoglobulin G1PatientsMonoclonal antibodiesCytometry analysisSimilar findingsBloodClonal restriction