2011
Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFcchimeric protein targeting tissue factor
Cocco E, Varughese J, Buza N, Bellone S, Glasgow M, Bellone M, Todeschini P, Carrara L, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Lockwood CJ, Santin AD. Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFcchimeric protein targeting tissue factor. BMC Cancer 2011, 11: 263. PMID: 21693061, PMCID: PMC3141777, DOI: 10.1186/1471-2407-11-263.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCarcinoma, Squamous CellCell Line, TumorComplement System ProteinsCytotoxicity Tests, ImmunologicDrug Screening Assays, AntitumorFemaleHuman papillomavirus 16Human papillomavirus 18HumansImmunoconjugatesImmunoglobulin GImmunotherapyInterleukin-2KeratinocytesMolecular Targeted TherapyNeoplasm ProteinsNeovascularization, PathologicPapillomavirus InfectionsRNA, MessengerRNA, NeoplasmThromboplastinUterine Cervical NeoplasmsConceptsCervical cancer cell linesPrimary cervical cancer cell linesCervical carcinoma cell linesCancer cell linesCervical cancerCarcinoma cell linesFactor VII/VIIaTissue factorUterine cervixCell linesImportant worldwide health problemTargeting tissue factorStandard treatment modalitySquamous cell carcinomaExpression of TFWorldwide health problemNovel therapeutic agentsNormal cervical keratinocytesAdenocarcinoma histologyBackgroundCervical cancerCancer refractoryRecurrent diseaseCell carcinomaTreatment modalitiesNovel therapies
2004
The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer
Cane' S, Bignotti E, Bellone S, Palmieri M, De Las Casas L, Roman JJ, Pecorelli S, Cannon MJ, O'Brien T, Santin AD. The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer. American Journal Of Obstetrics And Gynecology 2004, 190: 60-66. PMID: 14749636, DOI: 10.1016/j.ajog.2003.07.020.Peer-Reviewed Original ResearchConceptsCervical cancer cell linesReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionCancer cell linesCervical cancerCervical tumorsParaffin-embedded cervical cancer specimensPrimary cervical cancer cell linesCell linesPersistent cervical cancerNormal cervical epithelial cellsCervical cancer specimensCervical biopsy specimensChain reactionHuman cervical tumorsPrimary tumor cell linesCervical epithelial cellsCervical cancer therapyNovel molecular targetsGene 14Useful diagnostic toolFrequency of expressionPrimary adenocarcinomaStandard treatmentPolymerase chain reaction
1997
Adeno-Associated Virus Rep78 Inhibits Oncogenic Transformation of Primary Human Keratinocytes by a Human Papillomavirus Type 16-rasChimeric
Hermonat PL, Plott RT, Santin AD, Parham GP, Flick JT. Adeno-Associated Virus Rep78 Inhibits Oncogenic Transformation of Primary Human Keratinocytes by a Human Papillomavirus Type 16-rasChimeric. Gynecologic Oncology 1997, 66: 487-494. PMID: 9299265, DOI: 10.1006/gyno.1997.4789.Peer-Reviewed Original ResearchConceptsHuman papillomavirusCervical cancerCervical carcinogenesisPapillomavirus typesHPV 16/18 infectionHuman papillomavirus typesHuman papillomavirus type 16Primary human foreskin keratinocytesCell typesHPV-16 p97 promoterPapillomavirus type 16Ability of AAVPrimary human keratinocytesSeroepidemiologic studiesInverse associationHuman foreskin keratinocytesVirus infectionType 16Host cell typesTransient CAT assaysType 1P97 promoterOncogenic transformationForeskin keratinocytesHuman keratinocytes