2020
Phase II evaluation of copanlisib, a selective inhibitor of Pi3kca, in patients with persistent or recurrent endometrial carcinoma harboring PIK3CA hotspot mutations: An NRG Oncology study (NRG-GY008)
Santin AD, Filiaci V, Bellone S, Ratner ES, Mathews CA, Cantuaria G, Gunderson CC, Rutledge T, Buttin BM, Lankes HA, Frumovitz M, Khleif SN, Huh WK, Birrer MJ. Phase II evaluation of copanlisib, a selective inhibitor of Pi3kca, in patients with persistent or recurrent endometrial carcinoma harboring PIK3CA hotspot mutations: An NRG Oncology study (NRG-GY008). Gynecologic Oncology Reports 2020, 31: 100532. PMID: 31934607, PMCID: PMC6951478, DOI: 10.1016/j.gore.2019.100532.Peer-Reviewed Original ResearchProgression-free survivalStable diseaseOverall survivalMixed histologyPIK3CA mutationsGrade 5 adverse eventsMedian progression-free survivalCommon grade 3Common PIK3CA mutationCTCAE version 4GOG performance statusNRG Oncology StudyMedian overall survivalObjective tumor responsePhase II trialPhase II evaluationBest overall responsePIK3CA gene mutationsPIK3CA hotspot mutationsSelective inhibitorEligible patientsMeasurable diseaseHotspot PIK3CA mutationsII trialPrimary endpoint
2007
Overexpression of mammaglobin B in epithelial ovarian carcinomas
Tassi RA, Bignotti E, Rossi E, Falchetti M, Donzelli C, Calza S, Ravaggi A, Bandiera E, Pecorelli S, Santin AD. Overexpression of mammaglobin B in epithelial ovarian carcinomas. Gynecologic Oncology 2007, 105: 578-585. PMID: 17343903, DOI: 10.1016/j.ygyno.2007.01.043.Peer-Reviewed Original ResearchConceptsEpithelial ovarian carcinomaHuman ovarian surface epitheliumMammaglobin BOvarian cancerReal-time PCRBenign cystadenomasOvarian carcinomaNormal ovariesNovel ovarian cancer biomarkersB expressionNormal human ovarian surface epitheliumPrimary epithelial ovarian carcinomaSerous papillary ovarian cancerMammaglobin B mRNAMultiple histological typesOvarian cancer biopsiesSerous papillary tumorsClear cell tumorsOvarian surface epitheliumFresh frozen biopsiesOvarian cancer biomarkersParaffin-embedded tissuesMixed histologyBorderline tumorsHistologic type