The adeno-associated virus Rep78 major regulatory/transformation suppressor protein binds cellular Sp1 in vitro and evidence of a biological effect.
Hermonat PL, Santin AD, Batchu RB. The adeno-associated virus Rep78 major regulatory/transformation suppressor protein binds cellular Sp1 in vitro and evidence of a biological effect. Cancer Research 1996, 56: 5299-304. PMID: 8912872.Peer-Reviewed Original ResearchConceptsCellular Sp1Cellular transcription factor Sp1Transformation suppressor proteinRNA polymerase IITranscription factor Sp1Transcription initiation processHuman chromosome 19Sp1-dependent promotersLong terminal repeat promoterSite-specific integrationAAV DNA replicationFactor Sp1Polymerase IISp1 DNAPossible downstream effectsDNA replicationCoimmunoprecipitation analysisMultifunctional proteinSuppressor proteinBiological effectsAmino halfHeterologous promoterChromosome 19H-RasTranscriptional activity