2017
The effect of high-dose atorvastatin on neural activity and cognitive function
Taylor BA, Dager AD, Panza GA, Zaleski AL, Meda S, Book G, Stevens MC, Tartar S, White CM, Polk DM, Pearlson GD, Thompson PD. The effect of high-dose atorvastatin on neural activity and cognitive function. American Heart Journal 2017, 197: 166-174. PMID: 29447778, PMCID: PMC6083849, DOI: 10.1016/j.ahj.2017.10.027.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGreater activationStroop color-word scoresHopkins Verbal Learning Test-RevisedFigural memory tasksStandard neuropsychological assessmentColor-Word scoreStandard neuropsychological testsBrain activation patternsNeuropsychological test scoresSternberg taskBrain neural activationMemory taskFMRI taskTask versionsNeuropsychological testsNeural activationNeuropsychological assessmentCognitive testingEffect of statinsCognitive functionSignificant group-time interactionNeural activityBilateral precuneusClock Test
2014
Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism
Dager AD, McKay DR, Kent JW, Curran JE, Knowles E, Sprooten E, Göring H, Dyer TD, Pearlson GD, Olvera RL, Fox PT, Lovallo WR, Duggirala R, Almasy L, Blangero J, Glahn DC. Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism. Neuropsychopharmacology 2014, 40: 412-420. PMID: 25079289, PMCID: PMC4443955, DOI: 10.1038/npp.2014.187.Peer-Reviewed Original ResearchConceptsAmygdala volumeSubcortical volumesFamily historyLifetime AUDAlcohol-related damageGenetic factorsSmaller amygdala volumesPre-existing deficitsAUD riskSuch family historyStructural brain imagesBrain shrinkageDorsal striatumAlcohol abuseNeurotoxic damageVentral striatumSubcortical structuresCommon genetic factorsShared genetic factorsCommon genetic featuresUnrelated controlsMexican-American individualsGenetic featuresStriatumRisk