2014
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFluorine RadioisotopesFluorobenzenesGuanidinesHeartHumansMaleRadiometryRadionuclide ImagingRadiopharmaceuticalsTissue DistributionConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptake
2001
Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201?
Kailasnath P, Sinusas A. Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201? Cardiology In Review 2001, 9: 160-172. PMID: 11304401, DOI: 10.1097/00045415-200105000-00009.Peer-Reviewed Original ResearchMeSH KeywordsCoronary CirculationHumansMyocardial IschemiaOrganotechnetium CompoundsRadionuclide ImagingThalliumThallium RadioisotopesConceptsCoronary artery diseasePerfusion tracerPerfusion agentArtery diseaseMyocardial viabilityThallium-201Perfusion imagingMyocardial perfusion imagingRegional flow heterogeneityPharmacologic stressorChest painMyocardial perfusion agentRisk stratificationAcute assessmentNew perfusion agentTechnetium-99mClinical valueMyocardial uptakeIschemic regionAssessment of viabilityCoronary vasculatureMyocardial flowClearance kineticsMyocardial retentionTracer availability
2000
Severe regional ischemia alters coronary flow reserve in the remote perfusion area
Wu J, Yun J, Dione D, Heller E, Deckelbaum L, Sinusas A. Severe regional ischemia alters coronary flow reserve in the remote perfusion area. Journal Of Nuclear Cardiology 2000, 7: 43-52. PMID: 10698234, DOI: 10.1067/mnc.2000.99189.Peer-Reviewed Original ResearchConceptsLAD coronary flow reserveCoronary flow reserveLCX stenosisFlow reserveImpairment of CFRStenosis severityRemote nonischemic regionsRate-pressure productRegional myocardial dysfunctionDoppler flow probesTransstenotic pressure gradientOpen-chest dogsAcute canine modelIschemic dysfunctionAnterior descendingIntracoronary injectionMyocardial dysfunctionProximal LCXCoronary stenosisMyocardial infarctionAcute ischemiaProgressive impairmentPerfusion areaRegional myocardial flowTransstenotic gradient
1999
The potential for myocardial imaging with hypoxia markers
Sinusas A. The potential for myocardial imaging with hypoxia markers. Seminars In Nuclear Medicine 1999, 29: 330-338. PMID: 10534235, DOI: 10.1016/s0001-2998(99)80020-8.Peer-Reviewed Original Research
1998
Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy
Mattera J, Arain S, Sinusas A, Finta L, Wackers F. Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy. Journal Of Nuclear Cardiology 1998, 5: 498-506. PMID: 9796897, DOI: 10.1016/s1071-3581(98)90181-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary DiseaseCost SavingsElectrocardiographyExercise TestFemaleFollow-Up StudiesHeartHumansMaleMiddle AgedRadionuclide ImagingConceptsExercise myocardial perfusion imagingCoronary artery diseaseNormal exercise electrocardiogramMyocardial perfusion imagingNormal myocardial perfusion imagingNormal resting electrocardiogramsExercise electrocardiogramExercise testingArtery diseaseIntermediate likelihoodResting electrocardiogramsAbnormal myocardial perfusion imagingDiagnostic strategiesAbnormal exercise electrocardiogramGroup 3 patientsHard cardiac eventsNonfatal myocardial infarctionNormal baseline electrocardiogramSubsequent coronary revascularizationIncremental diagnostic informationDiagnostic testing strategiesCoronary revascularizationCardiac eventsUnstable anginaConsecutive patients
1996
Assessment of reperfusion after acute myocardial infarction: Is there a role for acute technetium 99m-teboroxime imaging?
Sinusas A. Assessment of reperfusion after acute myocardial infarction: Is there a role for acute technetium 99m-teboroxime imaging? Journal Of Nuclear Cardiology 1996, 3: 82-85. PMID: 8799231, DOI: 10.1016/s1071-3581(96)90027-6.Peer-Reviewed Original Research
1995
Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia.
Ng C, Sinusas A, Zaret B, Soufer R. Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia. Circulation 1995, 92: 1261-8. PMID: 7648674, DOI: 10.1161/01.cir.92.5.1261.Peer-Reviewed Original Research
1994
Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: Perfusion imaging during coronary angioplasty
Haronian H, Sinusas A, Remetz M, Brennan J, Cabin H, Zaret B, Wackers F. Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: Perfusion imaging during coronary angioplasty. Journal Of Nuclear Cardiology 1994, 1: 150-158. PMID: 9420682, DOI: 10.1007/bf02984087.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyLeft ventricular geometryAltered left ventricular geometryCoronary angioplastyRegional wall motionVentricular geometryEnd-diastolic imagesMyocardial perfusionExercise-induced myocardial ischemiaAbnormal regional wall motionMyocardial risk areaTransluminal coronary angioplastyQuantitative defectsExperimental animal modelsPlanar myocardial perfusionMyocardial perfusion imagingQuantitative technetiumResultsNine patientsVentricular functionCoronary arteryMyocardial infarctionVessel occlusionMyocardial ischemiaPerfusion defectsWall motion
1990
Experimental studies of the physiologic properties of technetium-99m isonitriles
Beller G, Sinusas A. Experimental studies of the physiologic properties of technetium-99m isonitriles. The American Journal Of Cardiology 1990, 66: e5-e8. PMID: 2145747, DOI: 10.1016/0002-9149(90)90605-z.Peer-Reviewed Original ResearchCardiac imaging with technetium 99m-labeled isonitriles
Sinusas A, Beller G, Watson D. Cardiac imaging with technetium 99m-labeled isonitriles. Journal Of Thoracic Imaging 1990, 5: 20-30. PMID: 2194038, DOI: 10.1097/00005382-199007000-00006.Peer-Reviewed Original ResearchConceptsMyocardial perfusionMyocardial injuryMyocardial ischemiaNoninvasive meansAcute coronary occlusionIschemic myocardial injuryIrreversible myocardial injurySingle-day protocolFull clinical implicationsFurther clinical studiesReversible myocardial ischemiaMyocardial dysfunctionMyocardial salvageCoronary occlusionClinical studiesMyocardial imaging agentClinical experienceTherapeutic interventionsInitial experienceClinical implicationsPerfusionIschemiaImaging agentInjuryRadiotracer
1989
Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201
Sinusas A, Watson D, Cannon J, Beller G. Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201. Journal Of The American College Of Cardiology 1989, 14: 1785-1793. PMID: 2584570, DOI: 10.1016/0735-1097(89)90034-x.Peer-Reviewed Original ResearchConceptsLow coronary flowThallium-201Postischemic dysfunctionMyocardial uptakeArtery occlusionMethoxyisobutyl isonitrileEndocardial flowCoronary flowGroup II dogsTwo-dimensional echocardiographyEffects of ischemiaRegional blood flowOpen-chest canine modelMyocardial perfusion agentEpicardial segmentsRadionuclide injectionBlood flowEndocardial segmentsRegional dysfunctionIschemic regionLeft ventricleCanine modelDysfunctionGroup IPerfusion agent
1984
Pathoanatomic correlates of regional left ventricular wall motion assessed by equilibrium radionuclide angiocardiography: A postmortem correlation
Sinusas A, Hardin N, Clements J, Wackers F. Pathoanatomic correlates of regional left ventricular wall motion assessed by equilibrium radionuclide angiocardiography: A postmortem correlation. The American Journal Of Cardiology 1984, 54: 975-981. PMID: 6496360, DOI: 10.1016/s0002-9149(84)80128-9.Peer-Reviewed Original ResearchConceptsAbnormal regional wall motionRegional wall motionPostmortem findingsPathoanatomic correlatesEquilibrium radionuclideLeft bundle branch blockNormal regional wall motionGross myocardial lesionsLeft ventricular wall motionBundle branch blockLeft ventricular segmentsRegional left ventricular wall motionVentricular wall motionFalse-negative segmentsCoronary arterySevere stenosisMyocardial infarctionNontransmural infarctionBranch blockVentricular segmentsWall motionMyocardial lesionsPatientsPredictive valueAbnormal segments