2023
Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressure
1995
962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging
Yun J, Wu J, Heller E, Deckelbaum L, Dione D, Liu Y, Wackers F, Sinusas A. 962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging. Journal Of The American College Of Cardiology 1995, 25: 217a. DOI: 10.1016/0735-1097(95)92360-h.Peer-Reviewed Original ResearchMB activityModerate stenosisDOB stressMean aortic pressureOpen-chest dogsSPECT perfusion imagingLCX stenosisProximal LCXPeak dobutamineAortic pressureDobutamine stressMB injectionChest dogsHeart rateNonischemicStenosisDobutamineIschemic regionPerfusion imagingFlow probeRadiolabeled microspheresFlow deficitsMicrosphere flowLimited valueBaseline