2023
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Leng S, Shaw A. Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective. Immunity & Ageing 2023, 20: 69. PMID: 38031077, PMCID: PMC10685665, DOI: 10.1186/s12979-023-00392-2.Peer-Reviewed Original Research
2022
Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults
Chou C, Mohanty S, Kang HA, Kong L, Avila‐Pacheco J, Joshi SR, Ueda I, Devine L, Raddassi K, Pierce K, Jeanfavre S, Bullock K, Meng H, Clish C, Santori FR, Shaw AC, Xavier RJ. Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults. Aging Cell 2022, 21: e13682. PMID: 35996998, PMCID: PMC9470889, DOI: 10.1111/acel.13682.Peer-Reviewed Original ResearchConceptsInfluenza vaccine responsesInfluenza vaccinationVaccine responsesHigh respondersAntibody responseImmune responseMore effective influenza vaccinesOlder adultsEffective influenza vaccinesSevere respiratory infectionsRobust immune responseLow antibody responseInfluenza vaccineRespiratory infectionsSignificant morbiditySeasonal influenzaInflammatory responseAge-related differencesDay 28Flu seasonOlder subjectsVaccinationHR subjectsMetabolomic signaturePlasma metabolites
2020
Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults
Avey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. The Journal Of Immunology 2020, 204: 1661-1673. PMID: 32060136, PMCID: PMC7755271, DOI: 10.4049/jimmunol.1900922.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAgingAntibodies, ViralCohort StudiesFemaleGene Expression ProfilingHemagglutination Inhibition TestsHumansImmunogenicity, VaccineInfluenza A virusInfluenza VaccinesInfluenza, HumanMaleNK Cell Lectin-Like Receptor Subfamily BOligonucleotide Array Sequence AnalysisSeasonsTranscriptomeVaccinationVaccines, InactivatedYoung AdultConceptsVaccine-induced Ab responsesOlder adultsInfluenza vaccinationDays postvaccinationInfluenza vaccineAb responsesMore effective influenza vaccinesImportant public health toolInactivated influenza vaccinationSeasonal influenza vaccineVaccine-induced immunityEffective influenza vaccinesMolecular signaturesEffects of immunosenescencePublic health toolImmune signaturesVaccination seasonVaccine responsesVaccine compositionSubset of individualsAge groupsHealth toolsSingle age groupAdultsPostvaccination
2015
Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination
Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging 2015, 7: 38-51. PMID: 25596819, PMCID: PMC4356402, DOI: 10.18632/aging.100720.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAgingCells, CulturedDNA, MitochondrialFemaleGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyHumansInfluenza VaccinesInfluenza, HumanLeukocytes, MononuclearMaleMitochondriaMitochondrial TurnoverOligonucleotide Array Sequence AnalysisOxidative PhosphorylationSeasonsTime FactorsTreatment OutcomeVaccinationYoung AdultConceptsPlasma cell signatureDay 2Influenza vaccinationDay 7Cell signatureOlder adultsInfluenza vaccine responsesAdults meeting criteriaType I interferon responseAge-associated impairmentAge-dependent alterationsI interferon responseMitochondrial biogenesisResponse signatureVaccine seasonVaccine respondersFrail subjectsInfluenza vaccineVaccine responsesVaccine responsivenessGene expression microarray analysisAbsent responseYounger respondersDay 28Meeting criteria
2013
An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans
Kang KS, Lee N, Shin MS, Kim SD, Yu Y, Mohanty S, Belshe RB, Montgomery RR, Shaw AC, Kang I. An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans. Clinical Immunology 2013, 147: 79-88. PMID: 23578549, PMCID: PMC3634098, DOI: 10.1016/j.clim.2013.02.022.Peer-Reviewed Original ResearchConceptsT cell immunityMemory T cellsIgG responsesHI antibody titersT cellsAntibody titersEffector memoryCell immunityHemagglutinin inhibition antibody titersDistinct T cell subsetsCytokine-producing capacityInactivated influenza vaccineCentral memory cellsT cell subsetsSpecific IgG responseSerum IgG responsesPotent survivalIL-17Influenza vaccineSignificant morbidityCell subsetsElderly peopleProliferative capacityTitersAltered relationship
2007
Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults
van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC. Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults. The Journal Of Infectious Diseases 2007, 195: 1590-1597. PMID: 17471428, DOI: 10.1086/516788.Peer-Reviewed Original ResearchConceptsInfluenza vaccine responsesYears of ageCD86 expressionPostvaccine titersVaccine responsesMean numberCD80/CD86 expressionCostimulatory B7 moleculesCostimulatory molecules CD80Toll-like receptorsAntiviral prophylaxisInfluenza vaccineVaccine antibodiesVaccine immunityB7 moleculesAlternative vaccinesActivated monocytesHemagglutination inhibitionDecile increaseInnate immunityMean increaseVaccine strainCD80Flow cytometryTiter increase