2022
Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchMeSH KeywordsGlutamic AcidHallucinationsHumansMagnetic Resonance SpectroscopyPsychotic DisordersSchizophreniaConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone
2020
Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience
Gold JM, Corlett PR, Strauss GP, Schiffman J, Ellman LM, Walker EF, Powers AR, Woods SW, Waltz JA, Silverstein SM, Mittal VA. Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience. Schizophrenia Bulletin 2020, 46: 1346-1352. PMID: 32648913, PMCID: PMC7707066, DOI: 10.1093/schbul/sbaa091.Peer-Reviewed Original ResearchConceptsClinical high riskComputational cognitive neuroscienceNew behavioral measureCognitive neuroscienceBehavioral measuresPsychosis risk predictionCognitive mechanismsTrait vulnerabilityDisorganization symptomsNeural systemsPsychosis symptomsPsychosis riskSpecialized interviewsPhenotype measuresNeuroscienceCHR assessmentTreatment targetsPsychotic disordersCourse of illnessInterview methodPsychosisNew treatment targetsIllness progressionPositive predictive valueMeasures
2019
From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses
Humpston CS, Adams RA, Benrimoh D, Broome MR, Corlett PR, Gerrans P, Horga G, Parr T, Pienkos E, Powers AR, Raballo A, Rosen C, Linden DEJ. From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses. Schizophrenia Bulletin 2019, 45: s56-s66. PMID: 30715542, PMCID: PMC6357975, DOI: 10.1093/schbul/sby073.Peer-Reviewed Original Research