2024
A computational account of the development and evolution of psychotic symptoms.
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024 PMID: 39260466, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityDiminished signal-to-noise ratioComputational accountPsychiatric interventionNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationA computational account of the development and evolution of psychotic symptoms
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024, 5 PMID: 38699166, PMCID: PMC11065053, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityComputational accountPsychiatric interventionDiminished signal-to-noise ratioNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formation
2023
Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms
Oliva H, Monteiro-Junior R, Oliva I, Powers A. Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 125: 110771. PMID: 37075881, DOI: 10.1016/j.pnpbp.2023.110771.Peer-Reviewed Original ResearchConceptsExercise interventionGeneral symptomsPsychotic symptomsEfficacy of exerciseEffects of exerciseSpecific brain areasWeb of ScienceCochrane CENTRALSymptom improvementTemporal lobeBrain areasLarge effect sizesPsychotic patientsPositive symptomsNegative symptomsSymptomsNeurobiological mechanismsNeurophysiology studiesInterventionExerciseEffect sizeDatabase searchSignificant improvementNeurobiological modelsPatients
2022
A computational lens on menopause-associated psychosis
Fisher VL, Ortiz LS, Powers AR. A computational lens on menopause-associated psychosis. Frontiers In Psychiatry 2022, 13: 906796. PMID: 35990063, PMCID: PMC9381820, DOI: 10.3389/fpsyt.2022.906796.Peer-Reviewed Original ResearchEstrogen declinePsychotic symptomsNew-onset psychosisPathogenesis of psychosisPsychotic episodeNeural pathwaysSymptom presentationAge groupsImpair functioningProtective factorsPsychosisRisk periodSymptomsPatient-specific pathwaysDisease statesEarly adulthoodBiological correlatesNeural mechanismsEstrogenSex differencesEpisodesLatent stateExtreme distressMenopausePathogenesisThree prominent self-report risk measures show unique and overlapping utility in characterizing those at clinical high-risk for psychosis
Williams TF, Powers AR, Ellman LM, Corlett PR, Strauss GP, Schiffman J, Waltz JA, Silverstein SM, Woods SW, Walker EF, Gold JM, Mittal VA. Three prominent self-report risk measures show unique and overlapping utility in characterizing those at clinical high-risk for psychosis. Schizophrenia Research 2022, 244: 58-65. PMID: 35597134, PMCID: PMC9829103, DOI: 10.1016/j.schres.2022.05.006.Peer-Reviewed Original ResearchConceptsProdromal Questionnaire-BriefPositive symptomsSelf-report questionnairesSpecific positive symptomsStructured Clinical InterviewClinical high riskCriterion validityHealthy controlsSpecific symptomsHigh riskDiscriminant validityPsychosis symptomsClinical InterviewCHR individualsStrong convergent validitySymptomsPsychosis riskNeuropsychological testsConsistent significant correlationLimited specificitySignificant correlationConvergent validityPsychosisConstruct validityQuestionnaire
2019
Reliability, Validity, Epidemiology, and Cultural Variation of the Structured Interview for Psychosis-Risk Syndromes (SIPS) and the Scale of Psychosis-Risk Symptoms (SOPS)
Woods S, Walsh B, Powers A, McGlashan T. Reliability, Validity, Epidemiology, and Cultural Variation of the Structured Interview for Psychosis-Risk Syndromes (SIPS) and the Scale of Psychosis-Risk Symptoms (SOPS). 2019, 85-113. DOI: 10.1007/978-3-030-17336-4_5.Peer-Reviewed Original ResearchPsychosis risk syndromePsychosis risk symptomsClinical high-risk syndromeHigh-risk syndromeStructured interviewsInter-rater reliabilityCHR casesSeverity ScaleSIPS diagnosesEpidemiology studiesTotal scoreSyndromeSymptom subtypesCHR sampleFavorable psychometric propertiesSymptomsPsychometric propertiesDiagnostic instrumentDiscriminant validityMedian inter-rater reliabilityGeneral itemsEpidemiologyPrevalencePsychosisSubtypes
2016
Varieties of Voice-Hearing: Psychics and the Psychosis Continuum
Powers AR, Kelley MS, Corlett PR. Varieties of Voice-Hearing: Psychics and the Psychosis Continuum. Schizophrenia Bulletin 2016, 43: 84-98. PMID: 28053132, PMCID: PMC5216860, DOI: 10.1093/schbul/sbw133.Peer-Reviewed Original ResearchConceptsPsychotic disordersSerious mental illnessVoice-hearing experiencesControl subjectsStudy populationProminent symptomContinuum of psychosisTreatment of voiceMental illnessProtective factorsPatientsNew study populationPsychosis continuumHelp-seeking groupDisordersHallucinatory experiencesVoice hearingSubjectsAuditory messagesVoice hearersPopulationSymptomsIllnessPsychosisDisease