2024
Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study
Krittanawong C, Ang S, Tangsrivimol J, Qadeer Y, Wang Z, Virk H, Khalid U, Sharma S, Dardik A. Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 108094. PMID: 39424210, DOI: 10.1016/j.jstrokecerebrovasdis.2024.108094.Peer-Reviewed Original ResearchAsymptomatic carotid stenosisCarotid artery stenosisCarotid stenosisArtery stenosisAdverse eventsCohort studyAsymptomatic extracranial carotid stenosisNational population-based cohort studyPopulation-based cohort studyAssociated with lower adverse eventsAssociated with high mortalityAlternative to CEAExtracranial carotid stenosisSymptomatic carotid stenosisMortality of patientsCarotid artery stentingLower adverse eventsNational cohort studyAsymptomatic patientsClinical characteristicsArtery stentingPatient populationCarotid endarterectomyStenosisPatientsAn International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR)
Paraskevas K, AbuRahma A, Abularrage C, Clair D, Eldrup-Jorgensen J, Kashyap V, Dardik A, de Borst G, Dermody M, Faggioli G, Hicks C, Kwolek C, Lyden S, Mansilha A, Van Herzeele I, Myrcha P, Leal Lorenzo J, Jim J, Pini R, Secemsky E, Spinelli F, Capoccia L, Stone D, Stoner M, Zeebregts C, Lal B, Schneider P, Malas M, Schermerhorn M. An International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR). Annals Of Vascular Surgery 2024 PMID: 39413993, DOI: 10.1016/j.avsg.2024.09.048.Peer-Reviewed Original ResearchTransfemoral carotid artery stentingTranscarotid artery revascularizationRandomized controlled trialsCarotid endarterectomyConsensus documentArtery revascularizationAlternative therapeutic modalityManagement of patientsCarotid artery stentingCarotid artery stenosisTreatment of restenosisCarotid stenosis patientsSymptomatic patientsStenosis patientsTherapeutic modalitiesCerebrovascular eventsArtery stenosisArtery stentingControlled trialsDelphi consensus processPatientsContraindicationsRevascularizationTranscarotidTrialsAssociation between Preoperative Neutrophil-lymphocyte Ratio and All-cause Mortality in Patients Treated with Thoracic Endovascular Aortic Repair for Degenerative Thoracic Aortic Aneurysm
Kano M, Nishibe T, Dardik A, Iwahashi T, Nakano Y, Shimahara Y. Association between Preoperative Neutrophil-lymphocyte Ratio and All-cause Mortality in Patients Treated with Thoracic Endovascular Aortic Repair for Degenerative Thoracic Aortic Aneurysm. Annals Of Vascular Surgery 2024, 110: 255-264. PMID: 39341560, DOI: 10.1016/j.avsg.2024.07.110.Peer-Reviewed Original ResearchThoracic endovascular aortic repairPatients treated with thoracic endovascular aortic repairDegenerative thoracic aortic aneurysmsPreoperative neutrophil-lymphocyte ratioNeutrophil-lymphocyte ratioThoracic aortic aneurysmAll-cause mortalityEndovascular aortic repairAortic repairAortic aneurysmCut-off values of neutrophil-lymphocyte ratioOptimal cut-off values of neutrophil-lymphocyte ratioElevated preoperative neutrophil-lymphocyte ratioOverall mortalityValue of neutrophil-lymphocyte ratioOptimal cut-off valueAbsolute lymphocyte countAbsolute neutrophil countRisk of overall mortalityLikelihood of all-cause mortalityReceiver operating characteristic curveIschemic heart diseaseLymphocyte countStratify patientsNeutrophil countEndothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease.
Zhang W, Gonzalez L, Li X, Bai H, Li Z, Taniguchi R, Langford J, Ohashi Y, Thaxton C, Yukihiko A, Yatsula B, Martin K, Goodwin J, Tellides G, Long X, Shu C, Dardik A. Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024 PMID: 39297205, DOI: 10.1161/atvbaha.124.320933.Peer-Reviewed Original ResearchChronic kidney diseaseTGF-b signalingArteriovenous fistula patencyArteriovenous fistulaKidney diseaseAVF patencyEndothelial cellsAssociated with endothelial injuryArteriovenous fistula diameterImprove AVF patencyIncreased outward remodelingReduced patencyInduced endothelial-to-mesenchymal transitionAortocaval fistula modelSmooth muscle cell proliferationArteriovenous fistula failureAttenuated EndMTEnd-stage kidney diseaseHuman arteriovenous fistulaeSmooth muscle cellsMuscle cell proliferationEndothelial-to-mesenchymal transitionMouse endothelial cellsInhibition of EndMTEndothelial-mesenchymal transitionEarly thrombus formation is required of eccentric and heterogenous neointimal hyperplasia under disturbed flow
Bai H, Li Z, Zhang W, Thaxton C, Ohashi Y, Gonzalez L, Kano M, Yatsula B, Hwa J, Dardik A. Early thrombus formation is required of eccentric and heterogenous neointimal hyperplasia under disturbed flow. Journal Of Thrombosis And Haemostasis 2024 PMID: 39173878, DOI: 10.1016/j.jtha.2024.07.028.Peer-Reviewed Original ResearchEndothelial cell lossArteriovenous fistulaSmooth muscle cellsNeointimal hyperplasiaHeterogeneous neointimaCell lossThrombus formationMT/mG reporter miceHuman arteriovenous fistulaeInhibit neointimal hyperplasiaEarly thrombus formationAntiplatelet therapyC57BL/6 miceReporter miceAVF failureWistar ratsVenous systemJuxta-anastomotic areaMuscle cellsAnimal modelsVenous outflowEarly thrombusEndothelial cellsArterial inflowThrombusWound Healing Society 2023 update on guidelines for arterial ulcers
Federman D, Dardik A, Shapshak D, Ueno C, Masterson L, Hopf H, Abdullah N, Junkins S, Mostow E. Wound Healing Society 2023 update on guidelines for arterial ulcers. Wound Repair And Regeneration 2024, 32: 619-629. PMID: 39021056, DOI: 10.1111/wrr.13204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRelevant new findingsLevel of evidenceEmergency medicine physiciansWound bed preparationAdjuvant therapySociety guidelinesWound Healing SocietyMedicine physiciansVascular surgeonsPlastic surgeonsInfection controlLong-term maintenanceBed preparationArterial ulcersUlcer managementWound healingArterial insufficiency ulcersSurgeonsWoundAdvisory PanelUlcersGuidelinesSurgeryHealing SocietyTherapyHeterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityHyperlipidemia and Comprehensive Vascular Events (CVEs) - a Novel Outcome Measure for Peripheral Arterial Disease
Tuttle M, Wells N, Hundito A, Alameddine D, Huttler J, Mena-Hurtado C, Turner J, Inzucchi S, Dardik A, Guzman R, Chaar C. Hyperlipidemia and Comprehensive Vascular Events (CVEs) - a Novel Outcome Measure for Peripheral Arterial Disease. Journal Of Vascular Surgery 2024, 79: e176-e177. DOI: 10.1016/j.jvs.2024.03.220.Peer-Reviewed Original ResearchA surgeon-scientist's approach to improving arteriovenous fistula patency
Dardik A. A surgeon-scientist's approach to improving arteriovenous fistula patency. JVS Vascular Science 2024, 5: 100207. PMID: 38975292, PMCID: PMC11225657, DOI: 10.1016/j.jvssci.2024.100207.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsA new rat model of aortic sympathetic denervation
Pavlyha M, Dardik A. A new rat model of aortic sympathetic denervation. JVS Vascular Science 2024, 5: 100205. PMID: 38962560, PMCID: PMC11219950, DOI: 10.1016/j.jvssci.2024.100205.Commentaries, Editorials and LettersModelling lower-limb peripheral arterial disease using clinically available datasets: impact of inflow boundary conditions on hemodynamic indices for restenosis prediction
Ninno F, Chiastra C, Colombo M, Dardik A, Strosberg D, Aboian E, Tsui J, Bartlett M, Balabani S, Díaz-Zuccarini V. Modelling lower-limb peripheral arterial disease using clinically available datasets: impact of inflow boundary conditions on hemodynamic indices for restenosis prediction. Computer Methods And Programs In Biomedicine 2024, 251: 108214. PMID: 38759252, DOI: 10.1016/j.cmpb.2024.108214.Peer-Reviewed Original ResearchComputational fluid dynamics resultsComputational fluid dynamicsInlet boundary conditionsInlet BCBoundary conditionsLow time-averaged WSSComputational fluid dynamics simulationsTime-averaged WSSNear-wall hemodynamicsInflow boundary conditionsInlet waveformCFD simulationsInflow conditionsFluid dynamicsInletSurface areaWaveformFlow velocityGeometry reconstructionSimulationAccurate estimationVelocity waveformsDoppler ultrasound imagingAcquisition timeScanningAbstract 2011: Development Of Machine Learning Model To Combine Clinical And Imaging Data For Prediction Of Endoleaks: Proof-of-concept Study
Kiang S, Roh D, Dardik A, Tomihama R. Abstract 2011: Development Of Machine Learning Model To Combine Clinical And Imaging Data For Prediction Of Endoleaks: Proof-of-concept Study. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a2011-a2011. DOI: 10.1161/atvb.44.suppl_1.2011.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curve curveArea under the receiver operating characteristic curveEndovascular aneurysm repairComputed tomography angiographyConvolutional neural networkClinical dataSupervised ML modelsML modelsRepresentative vectorsComputed tomography angiography scansOccurrence of endoleaksPropensity-matched patientsReceiver operating characteristic curveLearning modelsImage dataConvolutional neural network modelArea under the receiver operating curveComputed tomography angiography imagesReceiver operating curveTransform image dataProof-of-concept studyDeep learning modelsSupervised machine learning modelsAneurysm repairEndovascular casesAbstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure
Varsanik M, Thaxton C, Li W, Dardik A, Pocivavsek L. Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a3143-a3143. DOI: 10.1161/atvb.44.suppl_1.3143.Peer-Reviewed Original ResearchArteriovenous fistulaFistula failureNeointimal hyperplasiaLong-term dialysis accessFistula systemClinical problemEnd stage renal patientsPresence of arteriovenous fistulaStatic pressureArteriovenous fistula failureCT angiography scansMurine AVF modelStenotic veinsVenous stenosisAngiography scansStatic pressure peakDialysis accessFistulaAnesthetized miceRenal patientsVenous velocityFistula modelIn vivo validationHigh static pressureNative veinsAbstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy
Zhang W, Bai H, Gonzalez L, Li Z, Ohashi Y, Thaxton C, aoyagi Y, Yatsula B, Kano M, Xie Y, Cai Y, Chang S, Dardik A. Abstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a3092-a3092. DOI: 10.1161/atvb.44.suppl_1.3092.Peer-Reviewed Original ResearchChronic kidney diseaseSmooth muscle cellsEnd-stage renal diseaseArteriovenous fistulaHuman arteriovenous fistulaeControl miceC57BL/6J miceCKD showRate of primary failureBasilic vein transpositionTGF-bModel of arteriovenous fistulaTGF-b1 expressionArteriovenous fistula failureArteriovenous fistula maturationWild type miceControl C57BL/6J miceIncreased markers of autophagyTGF-b signalingVein transpositionAortocaval fistulaAVF maturationReceptor knockoutMT/mG miceSham nephrectomyAbstract 1130: Tenascin-C In Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics
Gonzalez L, Zhang W, Ohashi Y, Vazquez-Padron R, Dardik A. Abstract 1130: Tenascin-C In Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a1130-a1130. DOI: 10.1161/atvb.44.suppl_1.1130.Peer-Reviewed Original ResearchHuman dermal microvascular endothelial cellsInferior vena cavaThrombomodulin expressionTNC expressionPost-AVF creationWild-type C57BL/6 miceMale wild-type C57BL/6 miceOne-year patency rateDecreased thrombomodulin expressionIncreased thrombomodulin expressionArteriovenous fistula failureTenascin-CSites of tissue injuryTranslational therapeutic strategiesDermal microvascular endothelial cellsNF-kB expressionMicrovascular endothelial cellsAVF patencyVena cavaAVF creationSham surgeryC57BL/6 miceFistula failureAVF failureSuperior patencyClinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.
Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectivesDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, PMCID: PMC11380968, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVFLeveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease Patients
Song J, Tomihama R, Roh D, Cabrera A, Dardik A, Kiang S. Leveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease Patients. Annals Of Vascular Surgery 2024, 107: 48-54. PMID: 38582202, DOI: 10.1016/j.avsg.2023.11.057.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsReduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease
Nishibe T, Dardik A, Akiyama S, Kano M, Fukuda S, Koizumi J, Nishibe M. Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease. Annals Of Vascular Surgery 2024, 105: 275-281. PMID: 38570014, DOI: 10.1016/j.avsg.2023.12.094.Peer-Reviewed Original ResearchSkeletal muscle massPeripheral arterial diseaseBioelectrical impedance analysisAnkle-brachial indexAnkle-brachial pressure indexLeg skeletal muscle massLeg ischemiaMuscle massIntermittent claudicationLeg muscle massMuscle qualityArtery diseaseAssociated with reduced muscle massTokyo Medical University HospitalAssociated with skeletal muscle myopathyReduced muscle massMedical University HospitalLeg muscle qualitySkeletal muscle myopathyUniversity HospitalMuscle myopathyPatientsIschemiaClaudicationLower extremitiesWhy selective screening for asymptomatic carotid stenosis is currently appropriate: a special report
Paraskevas K, Dardik A, Schermerhorn M, Liapis C, Mansilha A, Lal B, Gray W, Brown M, Myrcha P, Lavie C, Zeebregts C, Secemsky E, Saba L, Blecha M, Gurevich V, Silvestrini M, Blinc A, Svetlikov A, Fernandes e Fernandes J, Schneider P, Gloviczki P, White C, AbuRahma A. Why selective screening for asymptomatic carotid stenosis is currently appropriate: a special report. Expert Review Of Cardiovascular Therapy 2024, 22: 159-165. PMID: 38480465, DOI: 10.1080/14779072.2024.2330660.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsScreening programMass screening programPopulation-wide screening programsRisk factor modificationHigh riskHigh risk of strokeMyocardial infarctionInitiation of preventive measuresRisk of strokeIntensive medical therapyAsymptomatic carotid artery stenosisFactor modificationCost-effectiveLifestyle measuresPrevent future strokeAsymptomatic carotid stenosisTargeted screeningCarotid artery stenosisFuture strokeScreening of populationsCarotid revascularization proceduresProphylactic carotid interventionMedical therapyPreventive measuresCV events