2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2023
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creationArterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentage
2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cells
2009
Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease. International Angiology 2009, 28: 484-9. PMID: 20087287.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiography, Digital SubtractionAngioplasty, BalloonAnkle Brachial IndexCase-Control StudiesChronic DiseaseFemaleFemoral ArteryHemodynamicsHumansIschemiaKaplan-Meier EstimateKidney DiseasesLimb SalvageMaleMiddle AgedPeripheral Vascular DiseasesRenal DialysisRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular PatencyConceptsPeripheral artery diseaseSuperficial femoral arteryChronic hemodialysisStent placementNondialysis groupPrimary patencyDialysis groupLimb ischemiaSFA lesionsArtery diseaseLimb salvageFemoral arteryFirst-choice therapeutic optionSymptomatic limb ischemiaCritical limb ischemiaPrimary stent placementClinical outcomesTherapeutic optionsHigh prevalenceOutcome measuresHemodialysisLower limbsPatientsSurvival ratePatency
2007
Laser Doppler skin perfusion pressure in the diagnosis of limb ischemia in patients with diabetes mellitus and/or hemodialysis.
Kondo Y, Muto A, Dardik A, Nishibe M, Nishibe T. Laser Doppler skin perfusion pressure in the diagnosis of limb ischemia in patients with diabetes mellitus and/or hemodialysis. International Angiology 2007, 26: 258-61. PMID: 17622208.Peer-Reviewed Original ResearchConceptsAnkle-brachial pressure indexSkin perfusion pressureFontaine stage IIPeripheral artery diseaseFontaine stage IIIFontaine stage IVDiabetes mellitusStage IILimb ischemiaPerfusion pressureStage IIIStage IVLaser Doppler skin perfusion pressureSeverity of PADBrachial pressure indexArtery diseaseHemodialysis patientsLaser Doppler techniqueLower limbsPatientsPressure indexLaser DopplerDoppler techniqueLimbMellitus