2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2023
The Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm
Nishibe T, Kano M, Akiyama S, Koizumi J, Dardik A. The Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm. Vascular And Endovascular Surgery 2023, 58: 178-184. PMID: 37789604, DOI: 10.1177/15385744231204238.Peer-Reviewed Original ResearchConceptsEndovascular aortic repairAbdominal aortic aneurysmLower preoperative LMROverall mortalityPreoperative LMRMonocyte ratioAortic repairIndependent predictorsAortic aneurysmChronic obstructive pulmonary diseaseTokyo Medical University HospitalAbsolute lymphocyte countObstructive pulmonary diseaseAbsolute monocyte countMedical University HospitalPotential surrogate biomarkerPoor nutritional statusCharacteristic curve analysisPreoperative lymphocyteActive cancerMedian followLymphocyte countMultivariable analysisPulmonary diseasePoor prognosisRates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020
Nguyen M, Gonzalez L, Newman A, Cannon A, Zarebski S, Chaudhry S, Pomahac B, Boatright D, Dardik A. Rates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020. JAMA Surgery 2023, 158: 756-764. PMID: 37195709, PMCID: PMC10193263, DOI: 10.1001/jamasurg.2023.1571.Peer-Reviewed Original ResearchConceptsHealth fundingNational InstituteNIH fundingCross-sectional studyDepartment of SurgeryGlobal disease burdenNumber of NIHNIH RePORTER databaseDisease burdenSurgical diseaseSurgical departmentPatient careResearch project grantsClinical settingSurgical subspecialtiesPhD scientistsSurgeryNIH grantsSubstantial disparitiesBoard certificationNIH investigatorsNIHClinical demandInvestigatorsProject grantsSex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creationCarbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease
Lee S, Ali S, Cardella J, Turner J, Guzman R, Dardik A, Ochoa Chaar C. Carbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease. Journal Of Vascular Surgery 2023, 78: 201-208. PMID: 36948278, DOI: 10.1016/j.jvs.2023.03.029.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseasePeripheral vascular interventionsContrast volume usagePC-AKICarbon dioxide angiographyCardiac complicationsPropensity matchingKidney diseaseVascular interventionsPost-contrast acute kidney injuryAcute kidney injuryOutcomes of patientsPeripheral arterial diseasePoor renal functionMultivariate logistic regressionLower contrast volumeVolume of contrastCardiac comorbiditiesKidney injuryMinor amputationRenal complicationsRenal functionEndovascular therapyArterial diseaseGender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020
Nguyen M, Gonzalez L, Chaudhry S, Ahuja N, Pomahac B, Newman A, Cannon A, Zarebski S, Dardik A, Boatright D. Gender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020. JAMA Network Open 2023, 6: e233630. PMID: 36939702, PMCID: PMC10028489, DOI: 10.1001/jamanetworkopen.2023.3630.Peer-Reviewed Original ResearchConceptsCross-sectional studyNIH fundingNational InstitutePatient-centered researchNIH RePORTER databaseWarrants further investigationPrincipal investigatorSurgical diseaseGlobal burdenMAIN OUTCOMEResearch project grantsSurgeonsWomenHealth fundingAcademic surgeonsMenNIH grantsDiseaseFurther investigationArterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentage
2022
Sclerotherapy Improves Symptoms in Patients with Small and Moderate Diameter Low-Flow Vascular Malformations: A Prospective Cohort Study
Leal B, Procópio R, Dardik A, Navarro T. Sclerotherapy Improves Symptoms in Patients with Small and Moderate Diameter Low-Flow Vascular Malformations: A Prospective Cohort Study. Annals Of Vascular Surgery 2022, 89: 68-77. PMID: 37466046, DOI: 10.1016/j.avsg.2022.09.051.Peer-Reviewed Original ResearchConceptsLow-flow vascular malformationsProspective cohort studyVascular malformationsLarger diameter lesionsQuality of lifeCohort studySymptom improvementPolidocanol foamFunctional limitationsFlow vascular malformationsPolidocanol foam sclerotherapyCommon clinical presentationOptimal patient selectionPatient-reported qualitySessions of sclerotherapyVisual analog scaleHospital das ClínicasDiameter lesionsCent of lesionsMean followRecurrent symptomsSymptom recurrenceClinical responseMost patientsCommon complication
2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cellsInhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation
Matsubara Y, Kiwan G, Liu J, Gonzalez L, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Dardik A. Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: e160-e174. PMID: 33472405, PMCID: PMC7904667, DOI: 10.1161/atvbaha.120.315875.Peer-Reviewed Original ResearchConceptsVascular wall thickeningT helper type 1 (Th1) cellsSuccessful AVF maturationAVF maturationRegulatory T cellsMacrophage accumulationT cellsType 1 cellsArteriovenous fistulaVenous remodelingWall thickeningMouse aortocaval fistula modelT helper type 2T helper type 2 cellsAdaptive remodelingM2 macrophage accumulationPrimary success rateAortocaval fistula modelArteriovenous fistula maturationPreferred vascular accessAnti-inflammatory macrophagesT cell functionWild-type miceEffect of CsAType 2 cells
2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Bai H, Sadaghianloo N, Gorecka J, Liu S, Ono S, Ramachandra AB, Bonnet S, Mazure NM, Declemy S, Humphrey JD, Dardik A. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Science Translational Medicine 2020, 12 PMID: 32817365, PMCID: PMC7705473, DOI: 10.1126/scitranslmed.aax7613.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaHemodialysis accessNeointimal hyperplasiaEndothelial nitric oxide synthaseDurable surgical optionUremic male ratsRadial-cephalic arteriovenous fistulaKruppel-like factor 2Nitric oxide synthasePeak systolic velocityLong-term patencyReintervention rateSecondary patencyImproved hemodynamicsFemale patientsReimplantation techniqueSurgical optionsSystolic velocityMale ratsOxide synthaseFistula modelPatencyHemodynamicsDifferent hemodynamicsFemale animals
2018
Increased mortality in octogenarians treated for lifestyle limiting claudication
Erben Y, Mena‐Hurtado C, Miller S, Jean R, Sumpio BJ, Velasquez CA, Mojibian H, Aruny J, Dardik A, Sumpio B. Increased mortality in octogenarians treated for lifestyle limiting claudication. Catheterization And Cardiovascular Interventions 2018, 91: 1331-1338. PMID: 29405592, DOI: 10.1002/ccd.27523.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDatabases, FactualEndovascular ProceduresFemaleHealth StatusHumansIntermittent ClaudicationLength of StayMaleMiddle AgedPeripheral Arterial DiseaseRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsCharlson Comorbidity IndexOpen surgeryTreatment modalitiesHigher Charlson comorbidity indexMean Charlson Comorbidity IndexYounger cohortsInfectious wound complicationsInfra-inguinal interventionsAcute kidney injuryPeripheral arterial diseasePeripheral artery diseaseCongestive heart failureNationwide Inpatient SampleBinary logistic regression analysisLogistic regression analysisSkilled nursing facilitiesTreatment of LLCHospital mortalityComorbidity indexExercise therapyHospital stayKidney injuryOverall morbidityWound complicationsLonger LOS
2017
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years
Powell J, Sweeting M, Ulug P, Blankensteijn J, Lederle F, Becquemin J, Greenhalgh R, , Greenhalgh R, Beard J, Buxton M, Brown L, Harris P, Powell J, Rose J, Russell I, Sculpher M, Thompson S, Lilford R, Bell P, Greenhalgh R, Whitaker S, Poole‐Wilson T, Ruckley C, Campbell W, Dean M, Ruttley M, Coles E, Powell J, Halliday A, Gibbs S, Brown L, Epstein D, Sculpher M, Thompson S, Hannon R, Johnston L, Bradbury A, Henderson M, Parvin S, Shepherd D, Greenhalgh R, Mitchell A, Edwards P, Abbott G, Higman D, Vohra A, Ashley S, Robottom C, Wyatt M, Rose J, Byrne D, Edwards R, Leiberman D, McCarter D, Taylor P, Reidy J, Wilkinson A, Ettles D, Clason A, Leen G, Wilson N, Downes M, Walker S, Lavelle J, Gough M, McPherson S, Scott D, Kessell D, Naylor R, Sayers R, Fishwick N, Harris P, Gould D, Walker M, Chalmers N, Garnham A, Collins M, Beard J, Gaines P, Ashour M, Uberoi R, Braithwaite B, Whitaker S, Davies J, Travis S, Hamilton G, Platts A, Shandall A, Sullivan B, Sobeh M, Matson M, Fox A, Orme R, Yusef W, Doyle T, Horrocks M, Hardman J, Blair P, Ellis P, Morris G, Odurny A, Vohra R, Duddy M, Thompson M, Loosemore T, Belli A, Morgan R, Adiseshiah M, Brookes J, McCollum C, Ashleigh R, Aukett M, Baker S, Barbe E, Batson N, Bell J, Blundell J, Boardley D, Boyes S, Brown O, Bryce J, Carmichael M, Chance T, Coleman J, Cosgrove C, Curran G, Dennison T, Devine C, Dewhirst N, Errington B, Farrell H, Fisher C, Fulford P, Gough M, Graham C, Hooper R, Horne G, Horrocks L, Hughes B, Hutchings T, Ireland M, Judge C, Kelly L, Kemp J, Kite A, Kivela M, Lapworth M, Lee C, Linekar L, Mahmood A, March L, Martin J, Matharu N, McGuigen K, Morris‐Vincent P, Murray S, Murtagh A, Owen G, Ramoutar V, Rippin C, Rowley J, Sinclair J, Spencer S, Taylor V, Tomlinson C, Ward S, Wealleans V, West J, White K, Williams J, Wilson L, Grobbee D, Blankensteijn J, Bak A, Buth J, Pattynama P, Verhoeven E, van Voorthuisen A, Blankensteijn J, Balm R, Buth J, Cuypers P, Grobbee D, Prinssen M, van Sambeek M, Verhoeven E, Baas A, Hunink M, van Engelshoven J, Jacobs M, de Mol B, van Bockel J, Balm R, Reekers J, Tielbeek X, Verhoeven E, Wisselink W, Boekema N, Heuveling L, Sikking I, Prinssen M, Balm R, Blankensteijn J, Buth J, Cuypers P, van Sambeek M, Verhoeven E, de Bruin J, Baas A, Blankensteijn J, Prinssen M, Buth J, Tielbeek A, Blankensteijn J, Balm R, Reekers J, van Sambeek M, Pattynama P, Verhoeven E, Prins T, van der Ham A, van der Velden J, van Sterkenburg S, ten Haken G, Bruijninckx C, van Overhagen H, Tutein Nolthenius R, Hendriksz T, Teijink J, Odink H, de Smet A, Vroegindeweij D, van Loenhout R, Rutten M, Hamming J, Lampmann L, Bender M, Pasmans H, Vahl A, de Vries C, Mackaay A, van Dortmont L, van der Vliet A, Schultze Kool L, Boomsma J, van Dop H, de Mol van Otterloo J, de Rooij T, Smits T, Yilmaz E, Wisselink W, van den Berg F, Visser M, van der Linden E, Schurink G, de Haan M, Smeets H, Stabel P, van Elst F, Poniewierski J, Vermassen F, Lederle F, Freischlag J, Kohler T, Latts E, Matsumura J, Padberg F, Kyriakides T, Swanson K, Guarino P, Peduzzi P, Antonelli M, Cushing C, Davis E, Durant L, Joyner S, Kossack T, Kyriakides T, LeGwin M, McBride V, O'Connor T, Poulton J, Stratton T, Zellner S, Snodgrass A, Thornton J, Swanson K, Haakenson C, Stroupe K, Jonk Y, Hallett J, Hertzer N, Towne J, Katz D, Karrison T, Matts J, Marottoli R, Kasl S, Mehta R, Feldman R, Farrell W, Allore H, Perry E, Niederman J, Randall F, Zeman M, Beckwith T, O'Leary T, Huang G, Latts E, Bader M, Ketteler E, Kingsley D, Marek J, Massen R, Matteson B, Pitcher J, Langsfeld M, Corson J, Goff J, Kasirajan K, Paap C, Robertson D, Salam A, Veeraswamy R, Milner R, Kasirajan K, Guidot J, Lal B, Busuttil S, Lilly M, Braganza M, Ellis K, Patterson M, Jordan W, Whitley D, Taylor S, Passman M, Kerns D, Inman C, Poirier J, Ebaugh J, Raffetto J, Chew D, Lathi S, Owens C, Hickson K, Dosluoglu H, Eschberger K, Kibbe M, Baraniewski H, Matsumura J, Endo M, Busman A, Meadows W, Evans M, Giglia J, El Sayed H, Reed A, Ruf M, Ross S, Jean‐Claude J, Pinault G, Kang P, White N, Eiseman M, Jones T, Timaran C, Modrall J, Welborn M, Lopez J, Nguyen T, Chacko J, Granke K, Vouyouka A, Olgren E, Chand P, Allende B, Ranella M, Yales C, Whitehill T, Krupski T, Nehler M, Johnson S, Jones D, Strecker P, Bhola M, Shortell C, Gray J, Lawson J, McCann R, Sebastian M, Kistler Tetterton J, Blackwell C, Prinzo P, Lee N, Padberg F, Cerveira J, Lal B, Zickler R, Hauck K, Berceli S, Lee W, Ozaki C, Nelson P, Irwin A, Baum R, Aulivola B, Rodriguez H, Littooy F, Greisler H, O'Sullivan M, Kougias P, Lin P, Bush R, Guinn G, Bechara C, Cagiannos C, Pisimisis G, Barshes N, Pillack S, Guillory B, Cikrit D, Lalka S, Lemmon G, Nachreiner R, Rusomaroff M, O'Brien E, Cullen J, Hoballah J, Sharp W, McCandless J, Beach V, Minion D, Schwarcz T, Kimbrough J, Ashe L, Rockich A, Warner‐Carpenter J, Moursi M, Eidt J, Brock S, Bianchi C, Bishop V, Gordon I, Fujitani R, Kubaska S, Behdad M, Azadegan R, Ma Agas C, Zalecki K, Hoch J, Carr S, Acher C, Schwarze M, Tefera G, Mell M, Dunlap B, Rieder J, Stuart J, Weiman D, Abul‐Khoudoud O, Garrett H, Walsh S, Wilson K, Seabrook G, Cambria R, Brown K, Lewis B, Framberg S, Kallio C, Barke R, Santilli S, d'Audiffret A, Oberle N, Proebstle C, Johnson L, Jacobowitz G, Cayne N, Rockman C, Adelman M, Gagne P, Nalbandian M, Caropolo L, Pipinos I, Johanning J, Lynch T, DeSpiegelaere H, Purviance G, Zhou W, Dalman R, Lee J, Safadi B, Coogan S, Wren S, Bahmani D, Maples D, Thunen S, Golden M, Mitchell M, Fairman R, Reinhardt S, Wilson M, Tzeng E, Muluk S, Peterson N, Foster M, Edwards J, Moneta G, Landry G, Taylor L, Yeager R, Cannady E, Treiman G, Hatton‐Ward S, Salabsky T, Kansal N, Owens E, Estes M, Forbes B, Sobotta C, Rapp J, Reilly L, Perez S, Yan K, Sarkar R, Dwyer S, Perez S, Chong K, Kohler T, Hatsukami T, Glickerman D, Sobel M, Burdick T, Pedersen K, Cleary P, Back M, Bandyk D, Johnson B, Shames M, Reinhard R, Thomas S, Hunter G, Leon L, Westerband A, Guerra R, Riveros M, Mills J, Hughes J, Escalante A, Psalms S, Day N, Macsata R, Sidawy A, Weiswasser J, Arora S, Jasper B, Dardik A, Gahtan V, Muhs B, Sumpio B, Gusberg R, Spector M, Pollak J, Aruny J, Kelly E, Wong J, Vasilas P, Joncas C, Gelabert H, DeVirgillio C, Rigberg D, Cole L, Becquemin J, Marzelle J, Becquemin J, Sapoval M, Becquemin J, Favre J, Watelet J, Lermusiaux P, Sapoval M, Lepage E, Hemery F, Dolbeau G, Hawajry N, Cunin P, Harris P, Stockx L, Chatellier G, Mialhe C, Fiessinger J, Pagny L, Kobeiter H, Boissier C, Lacroix P, Ledru F, Pinot J, Deux J, Tzvetkov B, Duvaldestin P, Watelet J, Jourdain C, David V, Enouf D, Ady N, Krimi A, Boudjema N, Jousset Y, Enon B, Blin V, Picquet J, L'Hoste P, Thouveny F, Borie H, Kowarski S, Pernes J, Auguste M, Becquemin J, Desgranges P, Allaire E, Marzelle J, Kobeiter H, Meaulle P, Chaix D, Juliae P, Fabiani J, Chevalier P, Combes M, Seguin A, Belhomme D, Sapoval M, Baque J, Pellerin O, Favre J, Barral X, Veyret C, Watelet J, Peillon C, Plissonier D, Thomas P, Clavier E, Lermusiaux P, Martinez R, Bleuet F, C D, Verhoye J, Langanay T, Heautot J, Koussa M, Haulon S, Halna P, Destrieux L, Lions C, Wiloteaux S, Beregi J, Bergeron P, Pinot J, Patra P, Costargent A, Chaillou P, D'Alicourt A, Goueffic Y, Cheysson E, Parrot A, Garance P, Demon A, Tyazi A, Pillet J, Lescalie F, Tilly G, Steinmetz E, Favier C, Brenot R, Krause D, Cercueil J, Vahdat O, Sauer M, Soula P, Querian A, Garcia O, Levade M, Colombier D, Cardon J, Joyeux A, Borrelly P, Dogas G, Magnan P, Branchereau A, Bartoli J, Hassen‐Khodja R, Batt M, Planchard P, Bouillanne P, Haudebourg P, Bayne J, Gouny P, Badra A, Braesco J, Nonent M, Lucas A, Cardon A, Kerdiles Y, Rolland Y, Kassab M, Brillu C, Goubault F, Tailboux L, Darrieux H, Briand O, Maillard J, Varty K, Cousins C. Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal Of Surgery 2017, 104: 166-178. PMID: 28160528, PMCID: PMC5299468, DOI: 10.1002/bjs.10430.Peer-Reviewed Original ResearchConceptsElective endovascular aneurysm repairEarly survival advantageEVAR groupOpen repairIndividual patient dataAbdominal aortic aneurysmSurvival advantageEVAR-1Artery diseaseAortic aneurysmPrevious coronary artery diseaseBrachial pressure indexModerate renal dysfunctionPeripheral artery diseaseCoronary artery diseaseEndovascular aneurysm repairPrespecified analysis planOperative mortalityRenal dysfunctionAneurysm repairEarly mortalityACE trialLower ankleLower mortalityMortality advantage
2015
Modified Petticoat Technique with Pre-placement of a Distal Bare Stent Improves Early Aortic Remodeling after Complicated Acute Stanford Type B Aortic Dissection
He H, Yao K, Nie W, Wang Z, Liang Q, Shu C, Dardik A. Modified Petticoat Technique with Pre-placement of a Distal Bare Stent Improves Early Aortic Remodeling after Complicated Acute Stanford Type B Aortic Dissection. European Journal Of Vascular And Endovascular Surgery 2015, 50: 450-459. PMID: 26100449, DOI: 10.1016/j.ejvs.2015.04.035.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionAortographyBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationChinaEndovascular ProceduresFemaleHumansMaleMiddle AgedPostoperative ComplicationsProsthesis DesignRecurrenceRetrospective StudiesStentsTime FactorsTomography, X-Ray ComputedTreatment OutcomeVascular RemodelingConceptsDistal bare stentAcute Stanford type B aortic dissectionStanford type B aortic dissectionType B aortic dissectionTrue-lumen collapseB aortic dissectionBare stentsAortic remodelingAortic dissectionComplete false lumen thrombosisLumen volumeDistal stent graftLate stent complicationsPrimary technical successLumen collapseDay mortality rateFalse lumen thrombosisTransient renal failureEndovascular aortic repairLong-term followFalse lumen volumeComputed tomography angiographyTrue lumen volumeDay morbidityPETTICOAT technique
2010
Expression and localization of vascular endothelial growth factor in normal abdominal aorta and abdominal aortic aneurysm.
Nishibe T, Dardik A, Kondo Y, Kudo F, Muto A, Nishi M, Nishibe M, Shigematsu H. Expression and localization of vascular endothelial growth factor in normal abdominal aorta and abdominal aortic aneurysm. International Angiology 2010, 29: 260-5. PMID: 20502414.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorAbdominal aortic aneurysmSmooth muscle cellsAortic aneurysmEndothelial growth factorEndothelial cellsAbdominal aortaPositive vascular endothelial growth factorNormal abdominal aortaAbdominal aortic aneurysm surgeryLocalization of VEGFExpression of VEGFGrowth factorNormal aortic samplesAbdominal aortic aneurysm samplesAortic aneurysm surgeryAneurysm samplesHuman abdominal aortic aneurysmImmunofluorescent double stainingAbdominal aorta samplesAneurysm surgeryRegulators of angiogenesisNormal human aortaAneurysm formationAutopsy specimens
2009
Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease. International Angiology 2009, 28: 484-9. PMID: 20087287.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiography, Digital SubtractionAngioplasty, BalloonAnkle Brachial IndexCase-Control StudiesChronic DiseaseFemaleFemoral ArteryHemodynamicsHumansIschemiaKaplan-Meier EstimateKidney DiseasesLimb SalvageMaleMiddle AgedPeripheral Vascular DiseasesRenal DialysisRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular PatencyConceptsPeripheral artery diseaseSuperficial femoral arteryChronic hemodialysisStent placementNondialysis groupPrimary patencyDialysis groupLimb ischemiaSFA lesionsArtery diseaseLimb salvageFemoral arteryFirst-choice therapeutic optionSymptomatic limb ischemiaCritical limb ischemiaPrimary stent placementClinical outcomesTherapeutic optionsHigh prevalenceOutcome measuresHemodialysisLower limbsPatientsSurvival ratePatencyFate of varicose veins after great saphenous vein stripping alone.
Nishibe T, Kondo Y, Dardik A, Muto A, Nishibe M. Fate of varicose veins after great saphenous vein stripping alone. International Angiology 2009, 28: 311-4. PMID: 19648875.Peer-Reviewed Original ResearchHybrid surgical and endovascular therapy in multifocal peripheral TASC D lesions: up to three-year follow-up.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Hybrid surgical and endovascular therapy in multifocal peripheral TASC D lesions: up to three-year follow-up. The Journal Of Cardiovascular Surgery 2009, 50: 493-9. PMID: 19734834.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, BalloonArterial Occlusive DiseasesCombined Modality TherapyConstriction, PathologicEndarterectomyFemaleFemoral ArteryHemodynamicsHumansIliac ArteryIschemiaKaplan-Meier EstimateLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Vascular DiseasesRadiographyReoperationStentsTime FactorsTreatment OutcomeVascular PatencyConceptsCommon femoral artery endarterectomyFemoral artery endarterectomyTASC D lesionsLimb salvage ratePrimary patency rateCritical limb ischemiaPeripheral artery diseaseCommon femoral arteryEndovascular therapySuperficial femoral arteryFemoral arteryPatency ratesArtery endarterectomyIntermittent claudicationArtery diseaseD lesionsLimb ischemiaSalvage rateLower limbsSurvival rateAssisted primary patencyVascular Surgery guidelinesThree-year experienceHemodynamic successPrimary patency
2008
Aneurysm Rupture after EVAR: Can the Ultimate Failure be Predicted?
Schlösser F, Gusberg R, Dardik A, Lin P, Verhagen H, Moll F, Muhs B. Aneurysm Rupture after EVAR: Can the Ultimate Failure be Predicted? European Journal Of Vascular And Endovascular Surgery 2008, 37: 15-22. PMID: 19008129, DOI: 10.1016/j.ejvs.2008.10.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAAA ruptureAAA rupture rateInitial AAA diameterCause of ruptureGraft failureFatal courseEmbase databasesInfection 6Procedural characteristicsAAA diameterAneurysm ruptureEVARRupture ratePatientsFocus of surveillanceComplete preventionEarly ruptureAAA rupture riskRupture riskAbnormalitiesRuptureRiskCauseEndoleakProtective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study.
Nishibe T, Kondo Y, Muto A, Dardik A, Ohara Y, Kainuma M, Takeda K. Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study. The Journal Of Cardiovascular Surgery 2008, 49: 627-31. PMID: 18670380.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnalysis of VarianceAortic Aneurysm, ThoracicAortic DissectionCardiopulmonary BypassChi-Square DistributionFemaleGlycineHumansLeukocyte CountLung DiseasesMalePilot ProjectsPostoperative ComplicationsRespiratory Function TestsSerine Proteinase InhibitorsSulfonamidesTreatment OutcomeConceptsAcute aortic dissectionAortic arch surgeryPostoperative lung dysfunctionSivelestat sodiumAortic dissectionCardiopulmonary bypassWhite blood cellsProtective effectArch surgerySivelestat groupLung dysfunctionControl groupBlood cellsPostoperative lung injuryAortic arch replacementArterial oxygen tensionArch replacementAcute typeLung injuryPulmonary functionCirculatory arrestDeep hypothermiaInflammatory reactionPatientsF ratio