2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2023
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creation
2016
3 Next generation ECM-based vascular biomaterials
Brownson K, Dardik A. 3 Next generation ECM-based vascular biomaterials. 2016, 19-40. DOI: 10.1016/b978-0-08-100166-0.00003-7.ChaptersVascular biomaterialsCarotid endarterectomySynthetic scaffold materialsLong-term strokeSuperior clinical outcomesPericardial patch closureMedical implantsPrimary arteriotomy closureScaffold materialsPatch closureClinical outcomesPseudoaneurysm formationSurgical closureArterial occlusionAutologous veinHemodialysis accessPericardial patchArteriotomy closureDeath riskPatient outcomesDiseased vesselsCardiovascular surgeryUmbilical veinLower riskVascular surgery today
2009
Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease. International Angiology 2009, 28: 484-9. PMID: 20087287.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiography, Digital SubtractionAngioplasty, BalloonAnkle Brachial IndexCase-Control StudiesChronic DiseaseFemaleFemoral ArteryHemodynamicsHumansIschemiaKaplan-Meier EstimateKidney DiseasesLimb SalvageMaleMiddle AgedPeripheral Vascular DiseasesRenal DialysisRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular PatencyConceptsPeripheral artery diseaseSuperficial femoral arteryChronic hemodialysisStent placementNondialysis groupPrimary patencyDialysis groupLimb ischemiaSFA lesionsArtery diseaseLimb salvageFemoral arteryFirst-choice therapeutic optionSymptomatic limb ischemiaCritical limb ischemiaPrimary stent placementClinical outcomesTherapeutic optionsHigh prevalenceOutcome measuresHemodialysisLower limbsPatientsSurvival ratePatency