2024
PAIN PROFILES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: ROLE OF PSYCHOSOCIAL FACTORS AND FEMALE SEX
Alashi A, Hurtado C, Romain G, Callegari S, Jacque F, Sinusas A, Smolderen K. PAIN PROFILES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: ROLE OF PSYCHOSOCIAL FACTORS AND FEMALE SEX. Journal Of The American College Of Cardiology 2024, 83: 2284. DOI: 10.1016/s0735-1097(24)04274-8.Peer-Reviewed Original Research
2023
The Potential Role of PET in the Management of Peripheral Artery Disease
Alashi A, Vermillion B, Sinusas A. The Potential Role of PET in the Management of Peripheral Artery Disease. Current Cardiology Reports 2023, 25: 831-839. PMID: 37314651, DOI: 10.1007/s11886-023-01904-8.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseLower extremitiesManagement of PADSetting of PADEarly detectionLarge vessel diseaseManagement of patientsNon-invasive testsPositron emission tomography (PET) imagingEmission Tomography ImagingNon-invasive toolVascular inflammationVessel diseaseMicrovascular perfusionRoutine screeningBlood flowClinical researchPatientsDiseaseTomography imagingPET imagingSkeletal musclePotential roleSummaryThe purpose
2022
Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Wadhwa R, Fava A, Lever HM, Thamilarasan M, Popovic ZB, Smedira NG, Desai MY. Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy. Progress In Cardiovascular Diseases 2022, 74: 11-18. PMID: 35952727, DOI: 10.1016/j.pcad.2022.08.002.Peer-Reviewed Original ResearchConceptsSeptal reduction therapyBNP ratioNT-proBNP ratioPrimary outcomeAsymptomatic patientsPrognostic valueObstructive hypertrophic cardiomyopathy patientsIncremental prognostic valueNormal NT-proBNPNT-pro BNPObstructive hypertrophic cardiomyopathyLong-term outcomesHypertrophic cardiomyopathy patientsCardiac transplantationNT-proBNPPrimary endpointCardiomyopathy patientsHypertrophic cardiomyopathyReduction therapyHigh riskPatientsDefibrillator dischargeSpline analysisOutcomesBNP
2021
INCREMENTAL PROGNOSTIC UTILITY OF CT-FFR IN PATIENTS WITHOUT KNOWN CORONARY ARTERY DISEASE UNDERGOING CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY
Smolka S, Alashi A, Marwan M, Fava A, Hutt E, Schoenhagen P, Popovic Z, Cremer P, Rodriguez L, Flamm S, Achenbach S, Desai M. INCREMENTAL PROGNOSTIC UTILITY OF CT-FFR IN PATIENTS WITHOUT KNOWN CORONARY ARTERY DISEASE UNDERGOING CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY. Journal Of The American College Of Cardiology 2021, 77: 1281. DOI: 10.1016/s0735-1097(21)02639-5.Peer-Reviewed Original Research
2020
Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity
Fava A, Mathias I, Alashi A, Saijo Y, Popovic Z, Thamilarasan M, Lever H, Desai M. Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity. European Heart Journal 2020, 41: ehaa946.2087. DOI: 10.1093/ehjci/ehaa946.2087.Peer-Reviewed Original ResearchDiastolic dysfunctionExercise capacityLVOT gradientMaximal exerciseHCM patientsLate mitral inflow velocityLateral mitral annular velocityMitral E/eAbnormal diastolic responseSymptomatic HCM patientsAtrial volume indexReduced exercise capacityVentricular filling pressureMitral annular velocityMitral inflow velocityHypertrophic cardiomyopathy patientsLogistic regression analysisHypertrophy cardiomyopathyDiastolic responseMetabolic equivalentsCardiomyopathy patientsAnnular velocityFilling pressureFunctional capacityPatientsExercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy
Fava A, Alashi A, Saijo Y, Mathias I, Popovic Z, Thamilarasan M, Lever H, Desai M. Exercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy. European Heart Journal 2020, 41: ehaa946.0081. DOI: 10.1093/ehjci/ehaa946.0081.Peer-Reviewed Original ResearchLV-GLSHypertrophic cardiomyopathyExercise capacityHCM patientsVentricular global longitudinal strainGlobal myocardial strainSymptomatic HCM patientsReduced exercise capacitySubclinical cardiac dysfunctionSubclinical myocardial dysfunctionGlobal longitudinal strainLVOT gradientCardiac deteriorationExercise impairmentCardiac dysfunctionMyocardial dysfunctionMaximal exerciseExercise testExercise variablesClinical utilityFunctional capacityPatientsMyocardial strainLogistic regressionLongitudinal strainLong-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting
Dunn AN, Donnellan E, Johnston DR, Alashi A, Reed GW, Jellis C, Krishnaswamy A, Gillinov AM, Svensson LG, Ellis S, Griffin BP, Kapadia SR, Pettersson GB, Desai MY. Long-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting. Circulation 2020, 142: 1399-1401. PMID: 33017210, DOI: 10.1161/circulationaha.120.046575.Peer-Reviewed Original ResearchLONG-TERM OUTCOMES AMONG PATIENTS WITH MEDIASTINAL RADIATION-INDUCED CORONARY ARTERY DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION VERSUS CORONARY ARTERY BYPASS GRAFTING
Dunn A, Donnellan E, Alashi A, Johnston D, Jellis C, Pettersson G, Svensson L, Reed G, Ellis S, Griffin B, Desai M. LONG-TERM OUTCOMES AMONG PATIENTS WITH MEDIASTINAL RADIATION-INDUCED CORONARY ARTERY DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION VERSUS CORONARY ARTERY BYPASS GRAFTING. Journal Of The American College Of Cardiology 2020, 75: 1150. DOI: 10.1016/s0735-1097(20)31777-0.Peer-Reviewed Original ResearchCLINICAL AND ECHOCARDIOGRAPHIC PARAMETERS IN PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: RELATIONSHIP TO LV GLOBAL LONGITUDINAL STRAIN
Klein J, Alashi A, Svensson L, Komarlu R, Saarel E, Aziz P, Najm H, Lever H, Zahka K, Desai M. CLINICAL AND ECHOCARDIOGRAPHIC PARAMETERS IN PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: RELATIONSHIP TO LV GLOBAL LONGITUDINAL STRAIN. Journal Of The American College Of Cardiology 2020, 75: 621. DOI: 10.1016/s0735-1097(20)31248-1.Peer-Reviewed Original Research
2019
Outcomes of Patients With Mediastinal Radiation-Associated Mitral Valve Disease Undergoing Cardiac Surgery
Donnellan E, Alashi A, Johnston DR, Gillinov AM, Pettersson GB, Svensson LG, Griffin BP, Desai MY. Outcomes of Patients With Mediastinal Radiation-Associated Mitral Valve Disease Undergoing Cardiac Surgery. Circulation 2019, 140: 1288-1290. PMID: 31589484, DOI: 10.1161/circulationaha.119.040546.Peer-Reviewed Original ResearchDifferent Histopathologic Diagnoses in Patients With Clinically Diagnosed Hypertrophic Cardiomyopathy After Surgical Myectomy
Alashi A, Desai RM, Khullar T, Hodges K, Rodriguez ER, Tan C, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Smedira NG, Desai MY. Different Histopathologic Diagnoses in Patients With Clinically Diagnosed Hypertrophic Cardiomyopathy After Surgical Myectomy. Circulation 2019, 140: 344-346. PMID: 31329486, DOI: 10.1161/circulationaha.119.040129.Peer-Reviewed Original ResearchCharacteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography
Gentry JL, Parikh PK, Alashi A, Gillinov AM, Pettersson GB, Rodriguez LL, Popovic ZB, Sato K, Grimm RA, Kapadia SR, Tuzcu EM, Svensson LG, Griffin BP, Desai MY. Characteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography. Circulation Cardiovascular Imaging 2019, 12: e009062. PMID: 31203672, DOI: 10.1161/circimaging.119.009062.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressureTreadmill stress echocardiographyVentricular systolic pressureStress echocardiographySystolic pressureMetabolic equivalentsMV gradientMitral proceduresHigh mortalityThoracic Surgeons scoreLong-term survivalAsymptomatic patientsCause mortalityPrimary outcomeSurgeons scoreConsecutive patientsImproved survivalContemporary patientsMV proceduresPatientsEchocardiographySignificant MSSurvival analysisModerate MSMortalityCHARACTERISTICS AND LONGER-TERM OUTCOMES OF PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE
Alashi A, Svensson L, Klein J, Zahka K, Smedira N, Najm H, Stewart R, Lever H, Aziz P, Saarel E, Desai M. CHARACTERISTICS AND LONGER-TERM OUTCOMES OF PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE. Journal Of The American College Of Cardiology 2019, 73: 878. DOI: 10.1016/s0735-1097(19)31485-8.Peer-Reviewed Original ResearchCHARACTERISTICS AND OUTCOMES OF PATIENTS WITH DOCUMENTED STRESS INDUCED (TAKOTSUBO) CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE
Alashi A, Faulx J, Menon V, Kapadia S, Ellis S, Faulx M, Griffin B, Desai M. CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH DOCUMENTED STRESS INDUCED (TAKOTSUBO) CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE. Journal Of The American College Of Cardiology 2019, 73: 877. DOI: 10.1016/s0735-1097(19)31484-6.Peer-Reviewed Original ResearchOUTCOMES OF PATIENTS WITH PRIOR MEDIASTINAL RADIOTHERAPY WHO DEVELOPED PREDOMINANTLY MITRAL VALVE DISEASE REQUIRING SURGERY
Donnellan E, Alashi A, Johnston D, Gillinov A, Svensson L, Griffin B, Desai M. OUTCOMES OF PATIENTS WITH PRIOR MEDIASTINAL RADIOTHERAPY WHO DEVELOPED PREDOMINANTLY MITRAL VALVE DISEASE REQUIRING SURGERY. Journal Of The American College Of Cardiology 2019, 73: 1983. DOI: 10.1016/s0735-1097(19)32589-6.Peer-Reviewed Original Research
2018
Rate of Progression of Aortic Stenosis and its Impact on Outcomes in Patients With Radiation-Associated Cardiac Disease A Matched Cohort Study
Donnellan E, Griffin BP, Johnston DR, Popovic ZB, Alashi A, Kapadia SR, Tuzcu EM, Krishnaswamy A, Mick S, Svensson LG, Desai MY. Rate of Progression of Aortic Stenosis and its Impact on Outcomes in Patients With Radiation-Associated Cardiac Disease A Matched Cohort Study. JACC Cardiovascular Imaging 2018, 11: 1072-1080. PMID: 29909108, DOI: 10.1016/j.jcmg.2018.04.019.Peer-Reviewed Original ResearchConceptsAortic valve replacementLong-term mortalityModerate aortic stenosisAortic stenosisRate of progressionPrior XRTLong-term survivalXRT groupHigher long-term mortalityAortic valve gradientMatched Cohort StudyComparison groupBasis of ageMediastinal radiotherapyCause mortalityValve gradientCohort studyValve replacementMore patientsXRT patientsPatientsHigh mortalityMortalityPrior exposureProgressionLONG TERM OUTCOMES AFTER AORTIC VALVE SURGERY IN PATIENTS WITH ASYMPTOMATIC CHRONIC AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION: ROLE OF PRE AND POST-OPERATIVE GLOBAL LONGITUDINAL STRAIN
Khullar T, Alashi A, Mentias A, Johnston D, Gillinov A, Rodriguez L, Svensson L, Popovic Z, Griffin B, Desai M. LONG TERM OUTCOMES AFTER AORTIC VALVE SURGERY IN PATIENTS WITH ASYMPTOMATIC CHRONIC AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION: ROLE OF PRE AND POST-OPERATIVE GLOBAL LONGITUDINAL STRAIN. Journal Of The American College Of Cardiology 2018, 71: a2014. DOI: 10.1016/s0735-1097(18)32555-5.Peer-Reviewed Original ResearchPRESERVED LEFT VENTRICULAR EJECTION FRACTIONAsymptomatic chronic aortic regurgitationLeft ventricular ejection fractionAortic valve surgeryChronic aortic regurgitationVentricular ejection fractionGlobal longitudinal strainLong-term outcomesValve surgeryAortic regurgitationEjection fractionTerm outcomesRole of preLongitudinal strainRegurgitationPatientsSurgery
2017
P187Long-term mortality after surgical aortic valve replacement in patients with normal left ventricular systolic function: incremental utility of valvuloarterial impedence and left ventricular strain
Huded C, Kusunose K, Goodman A, Alashi A, Shahid F, Grimm R, Gillinov A, Johnston D, Rodriguez L, Svensson L, Griffin B, Desai M. P187Long-term mortality after surgical aortic valve replacement in patients with normal left ventricular systolic function: incremental utility of valvuloarterial impedence and left ventricular strain. European Heart Journal 2017, 38: ehx501.p187. DOI: 10.1093/eurheartj/ehx501.p187.Peer-Reviewed Original Research
2016
OUTCOMES OF PATIENTS WITH ≥3+ AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION: A SINGLE TERTIARY CARE CENTER EXPERIENCE
Mentias A, Feng K, Alashi A, Rodriguez L, Gillinov A, Sabik J, Svensson L, Griffin B, Desai M. OUTCOMES OF PATIENTS WITH ≥3+ AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION: A SINGLE TERTIARY CARE CENTER EXPERIENCE. Journal Of The American College Of Cardiology 2016, 67: 2204. DOI: 10.1016/s0735-1097(16)32205-7.Peer-Reviewed Original ResearchAGE-GENDER PREDICTED EXERCISE CAPACITY PROVIDES INCREMENTAL PROGNOSTIC UTILITY IN PATIENTS WITH ≥3+ AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR SYSTOLIC FUNCTION AND DIMENSIONS: AN EXERCISE ECHOCARDIOGRAPHIC STUDY
Mentias A, Alashi A, Feng K, Rodriguez L, Gillinov A, Sabik J, Svensson L, Griffin B, Desai M. AGE-GENDER PREDICTED EXERCISE CAPACITY PROVIDES INCREMENTAL PROGNOSTIC UTILITY IN PATIENTS WITH ≥3+ AORTIC REGURGITATION AND PRESERVED LEFT VENTRICULAR SYSTOLIC FUNCTION AND DIMENSIONS: AN EXERCISE ECHOCARDIOGRAPHIC STUDY. Journal Of The American College Of Cardiology 2016, 67: 1650. DOI: 10.1016/s0735-1097(16)31651-5.Peer-Reviewed Original Research