Rapid label‐free profiling of oral cancer biomarker proteins using nano‐UPLC‐Q‐TOF ion mobility mass spectrometry
Nassar AF, Williams BJ, Yaworksy DC, Patel V, Rusling JF. Rapid label‐free profiling of oral cancer biomarker proteins using nano‐UPLC‐Q‐TOF ion mobility mass spectrometry. Proteomics Clinical Applications 2016, 10: 280-289. PMID: 26684082, DOI: 10.1002/prca.201500025.Peer-Reviewed Original ResearchConceptsIon mobility mass spectrometryCancer biomarker proteinsMass spectrometryNano-UPLCMobility mass spectrometryInterleukin-8Biomarker proteinsClinical cancer diagnosticsIon mobilityComplex samplesLabel-free profilingVascular endothelial growth factorOral cancer cellsOral cancer samplesCancer cell mediumEndothelial growth factorLabel proteinsIsotope labelingStable isotope labelingRelative quantitationSpectrometryClinical relevanceCancer cell culturesProteolytic digestionCancer development