Role of molecular markers to predict distant metastasis in papillary thyroid carcinoma: Promising value of TERT promoter mutations and insignificant role of BRAF mutations—a meta-analysis
Vuong H, Altibi A, Duong U, Ngo H, Pham T, Tran H, Oishi N, Mochizuki K, Nakazawa T, Hassell L, Katoh R, Kondo T. Role of molecular markers to predict distant metastasis in papillary thyroid carcinoma: Promising value of TERT promoter mutations and insignificant role of BRAF mutations—a meta-analysis. Tumor Biology 2017, 39: 1010428317713913. PMID: 29037127, DOI: 10.1177/1010428317713913.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerTERT promoter mutationsDistant metastasisThyroid cancerPromoter mutationsRET/PTC rearrangementsBRAF mutationsPresence of distant metastasesAssessment of patient prognosisTumor risk stratificationAssociated with distant metastasisPapillary thyroid carcinomaMeta-analysisPredicting distant metastasisAssociation of BRAFRandom-effects modelThyroid carcinomaTERT promoterRisk stratificationPatient prognosisRAS mutationsAdverse outcomesMetastasisIncreased riskBRAFTERT promoter mutation and its interaction with IDH mutations in glioma: Combined TERT promoter and IDH mutations stratifies lower-grade glioma into distinct survival subgroups—A meta-analysis of aggregate data
Vuong H, Altibi A, Duong U, Ngo H, Pham T, Chan A, Park C, Fung K, Hassell L. TERT promoter mutation and its interaction with IDH mutations in glioma: Combined TERT promoter and IDH mutations stratifies lower-grade glioma into distinct survival subgroups—A meta-analysis of aggregate data. Critical Reviews In Oncology/Hematology 2017, 120: 1-9. PMID: 29198322, DOI: 10.1016/j.critrevonc.2017.09.013.Peer-Reviewed Original ResearchConceptsTelomerase reverse transcriptase promoter mutationTelomerase reverse transcriptaseIsocitrate dehydrogenase mutation statusProgression-free survivalTERT promoter mutationsIsocitrate dehydrogenase mutationPromoter mutationsIDH-mutantGlioma patientsOverall survivalTumor gradeMutation statusTelomerase reverse transcriptase mutationsAssociated with reduced OSGrade II/III tumorsWHO grade IIMeta-analysisIDH-wild typeInverse variance methodRandom-effects modelII/III tumorsTERT-mutIII tumorsPrognostic factorsPrognostic valuePrognostic implication of BRAF and TERT promoter mutation combination in papillary thyroid carcinoma—A meta‐analysis
Vuong H, Altibi A, Duong U, Hassell L. Prognostic implication of BRAF and TERT promoter mutation combination in papillary thyroid carcinoma—A meta‐analysis. Clinical Endocrinology 2017, 87: 411-417. PMID: 28666074, DOI: 10.1111/cen.13413.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsPapillary thyroid carcinomaPromoter mutationsRisk stratificationRisk stratification of papillary thyroid carcinomaAssociated with increased tumor aggressivenessManagement of papillary thyroid carcinomaGroup of papillary thyroid carcinomasPapillary thyroid carcinoma patientsPooled estimates of odds ratiosCombination of BRAFEstimates of odds ratiosRandom-effects modelCoexisting BRAFThyroid carcinomaPrognostic implicationsTumor aggressivenessClinicopathological implicationsBRAFClinical managementConcurrent BRAFRisk groupsOdds ratioVirtual Health LibraryWeb of ScienceA meta-analysis of prognostic roles of molecular markers in papillary thyroid carcinoma
Vuong H, Duong U, Altibi A, Ngo H, Pham T, Tran H, Gandolfi G, Hassell L. A meta-analysis of prognostic roles of molecular markers in papillary thyroid carcinoma. Endocrine Connections 2017, 6: r8-r17. PMID: 28219937, PMCID: PMC5424840, DOI: 10.1530/ec-17-0010.Peer-Reviewed Original ResearchDisease-specific survivalDisease-free survivalPapillary thyroid carcinomaKaplan-Meier curvesPromoter mutationsHazard ratioPrognostic roleThyroid carcinomaData of hazard ratioVirtual Health LibraryAssess patient prognosisPooled hazard ratioInverse variance methodConfidence intervalsPrognosis of PTC patientsPredicting patient outcomesVisual inspection of funnel plotsMeta-analysesInspection of funnel plotsRandom-effects modelPrognostic valuePTC patientsEgger's regression testRisk stratificationPatient prognosis