TERT promoter mutation and its interaction with IDH mutations in glioma: Combined TERT promoter and IDH mutations stratifies lower-grade glioma into distinct survival subgroups—A meta-analysis of aggregate data
Vuong H, Altibi A, Duong U, Ngo H, Pham T, Chan A, Park C, Fung K, Hassell L. TERT promoter mutation and its interaction with IDH mutations in glioma: Combined TERT promoter and IDH mutations stratifies lower-grade glioma into distinct survival subgroups—A meta-analysis of aggregate data. Critical Reviews In Oncology/Hematology 2017, 120: 1-9. PMID: 29198322, DOI: 10.1016/j.critrevonc.2017.09.013.Peer-Reviewed Original ResearchConceptsTelomerase reverse transcriptase promoter mutationTelomerase reverse transcriptaseIsocitrate dehydrogenase mutation statusProgression-free survivalTERT promoter mutationsIsocitrate dehydrogenase mutationPromoter mutationsIDH-mutantGlioma patientsOverall survivalTumor gradeMutation statusTelomerase reverse transcriptase mutationsAssociated with reduced OSGrade II/III tumorsWHO grade IIMeta-analysisIDH-wild typeInverse variance methodRandom-effects modelII/III tumorsTERT-mutIII tumorsPrognostic factorsPrognostic valueBRAF Mutation is Associated with an Improved Survival in Glioma—a Systematic Review and Meta-analysis
Vuong H, Altibi A, Duong U, Ngo H, Pham T, Fung K, Hassell L. BRAF Mutation is Associated with an Improved Survival in Glioma—a Systematic Review and Meta-analysis. Molecular Neurobiology 2017, 55: 3718-3724. PMID: 28534272, DOI: 10.1007/s12035-017-0599-y.Peer-Reviewed Original ResearchConceptsProgression-free survivalKaplan Meier curveOverall survivalBRAF V600EPrognostic valueBRAF mutationsGlioma patientsImproved survivalData of hazard ratioHazard ratioYoung adult gliomasImproved overall survivalMeta-analysisInverse variance methodLow grade gliomasVirtual Health LibraryPrognosis of glioma patientsRandom-effects modelPrognostic impactPrognostic factorsTumor gradeFavorable prognosisPatient ageAdult gliomasPooled HR