Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair
QUINN T, MAUNG A, GRODZINSKY A, HUNZIKER E, SANDY J. Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair. Annals Of The New York Academy Of Sciences 1999, 878: 420-441. PMID: 10415746, DOI: 10.1111/j.1749-6632.1999.tb07700.x.Peer-Reviewed Original ResearchConceptsInjurious compressionProteoglycan turnoverIL-1 betaCartilage explantsQuantitative autoradiographyClinical strategiesCartilage injuryMatrix metabolismMatrix degradationProteoglycan depositionTissue degradationBiomechanical pathwaysCell-associated matrixBiomechanical rolePossible new approachCartilage repair strategiesViable chondrocytesAdult bovineChondrocytesCartilage repairChondrocyte phenotypeRepairPG degradationExtracellular matrixCatabolic process