2022
Effect of Antibiotic Duration in Emergency General Surgery Patients with Intra-Abdominal Infection Managed with Open vs Closed Abdomen.
Diaz JJ, Zielinski MD, Chipman AM, O'Meara L, Schroeppel T, Cullinane D, Shoultz T, Barnes SL, May AK, Maung AA. Effect of Antibiotic Duration in Emergency General Surgery Patients with Intra-Abdominal Infection Managed with Open vs Closed Abdomen. Journal Of The American College Of Surgeons 2022, 234: 419-427. PMID: 35290260, DOI: 10.1097/xcs.0000000000000126.Peer-Reviewed Original ResearchConceptsIntra-abdominal infectionsOpen abdomenSecondary infectionAntibiotic durationClosed abdomenOA patientsExact testHigher Sequential Organ Failure AssessmentSequential Organ Failure AssessmentEmergency general surgery patientsChi-square/Fisher's exact testDuration of antibioticsAPACHE II scoreGeneral surgery patientsOrgan Failure AssessmentHigh rateAnesthesiologists physical statusFisher's exact testTwenty-one centersII scoreSurgery patientsOverall mortalityPrimary outcomeMean durationAntibiotic treatment
2021
Increased mortality with resuscitative endovascular balloon occlusion of the aorta only mitigated by strong unmeasured confounding: An expanded analysis using the National Trauma Data Bank
Linderman GC, Lin W, Becher RD, Maung AA, Bhattacharya B, Davis KA, Schuster KM. Increased mortality with resuscitative endovascular balloon occlusion of the aorta only mitigated by strong unmeasured confounding: An expanded analysis using the National Trauma Data Bank. Journal Of Trauma And Acute Care Surgery 2021, 91: 790-797. PMID: 33951027, PMCID: PMC8547242, DOI: 10.1097/ta.0000000000003265.Peer-Reviewed Original ResearchConceptsAcute kidney injuryResuscitative endovascular balloon occlusionLower extremity amputationEndovascular balloon occlusionBalloon occlusionExtremity amputationTraumatic injuryTreatment weightingREBOA placementNational Trauma Data BankInverse probabilityPlacement of REBOATrauma Data BankSevere traumatic injuryMortality effectsUnmeasured confoundersNoncompressible torso hemorrhagePotent confounderTQIP dataTQIP databaseAortic injuryKidney injuryRetrospective studyInjury patternsBaseline variablesImproved outcomes using laparoscopy for emergency colectomy after mitigating bias by negative control exposure analysis
Linderman GC, Lin W, Sanghvi MR, Becher RD, Maung AA, Bhattacharya B, Davis KA, Schuster KM. Improved outcomes using laparoscopy for emergency colectomy after mitigating bias by negative control exposure analysis. Surgery 2021, 171: 305-311. PMID: 34332782, DOI: 10.1016/j.surg.2021.06.048.Peer-Reviewed Original ResearchConceptsOpen surgeryEmergency colectomyNational Surgical Quality Improvement Program dataQuality Improvement Program dataPostoperative septic shockLow-risk patientsSurgical site infectionPatients meeting criteriaColorectal emergenciesElective colectomyUnderwent laparoscopyHospital stayOverall morbidityNationwide registryAnastomotic leakColectomy casesConverted groupSeptic shockSite infectionPatient selectionBaseline variablesImproved outcomesLaparoscopic surgeryTreatment weightingColectomyAnticoagulation Is Associated with Increased Mortality in Splenic Injuries
Bhattacharya B, Becher RD, Schuster KM, Davis KA, Maung AA. Anticoagulation Is Associated with Increased Mortality in Splenic Injuries. Journal Of Surgical Research 2021, 266: 1-5. PMID: 33975026, DOI: 10.1016/j.jss.2021.04.002.Peer-Reviewed Original ResearchConceptsNon-ACS patientsSplenic injuryAC patientsMultivariable binary logistic regressionIndependent risk factorEffect of anticoagulationInjury Severity ScoreUnits of RBCsBinary logistic regressionHospital courseMedian LOSIncreased MortalitySeverity scoreRisk factorsWorse outcomesAnticoagulationSplenic surgeryAC groupPatientsHigh mortalityInjuryLogistic regressionMortalitySerious injuriesAngiographySex-based differences in helmet performance in bicycle trauma
Feler J, Maung AA, O'Connor R, Davis KA, Gerrard J. Sex-based differences in helmet performance in bicycle trauma. Journal Of Epidemiology & Community Health 2021, 75: 994-1000. PMID: 33827896, DOI: 10.1136/jech-2020-215544.Peer-Reviewed Original ResearchConceptsSex-based differencesBicycle traumaHead injuryHelmet useMultivariable logistic regression modelPatients 18 yearsRetrospective cohort studyNational Trauma DatabaseCervical spine fracturesSevere head injuryShort-term outcomesMotor vehicle collisionsSerious head injuryLogistic regression modelsAnticoagulant useCohort studyInjury overallIntracranial bleedingSpine fracturesTrauma databaseIntracranial hemorrhageCommon injuriesOdds reductionReduced oddsSkull fracture
2020
Choosing the Best Approach to Warfarin Reversal After Traumatic Intracranial Hemorrhage
Lumas SG, Hsiang W, Becher RD, Maung AA, Davis KA, Schuster KM. Choosing the Best Approach to Warfarin Reversal After Traumatic Intracranial Hemorrhage. Journal Of Surgical Research 2020, 260: 369-376. PMID: 33388533, DOI: 10.1016/j.jss.2020.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsBlood Coagulation FactorsCoagulantsConnecticutFemaleFollow-Up StudiesHospital CostsHumansIntracranial Hemorrhage, TraumaticLinear ModelsLogistic ModelsMaleMultivariate AnalysisPlasmaPractice Patterns, Physicians'Retrospective StudiesTomography, X-Ray ComputedTrauma CentersTreatment OutcomeWarfarinConceptsProthrombin complex concentrateFresh frozen plasmaTraumatic intracranial hemorrhageIntracranial hemorrhageWarfarin reversalReversal agentsUse of FFPAcademic level 1 trauma centerFollow-up computed tomography scanProgression of ICHFollow-up computed tomographyLevel 1 trauma centerComputed tomography scanTerms of mortalityElectronic medical recordsPreinjury warfarinElderly patientsHospital lengthInitial bleedICH progressionICH patientsMultivariable analysisRetrospective studyTrauma centerSurgical interventionSurvivors of gun violence and the experience of recovery.
O'Neill KM, Vega C, Saint-Hilaire S, Jahad L, Violano P, Rosenthal MS, Maung AA, Becher RD, Dodington J. Survivors of gun violence and the experience of recovery. Journal Of Trauma And Acute Care Surgery 2020, 89: 29-35. PMID: 32118821, DOI: 10.1097/ta.0000000000002635.Peer-Reviewed Original ResearchConceptsGun violenceQualitative research studyCommunity-based organizationsCommunity-based participatory research approachInterview transcript dataParticipatory research approachSense of safetyExperience of recoveryRepeat violenceConstant comparison methodMental health treatmentViolenceCommunity membersViolent recidivismDepth oneResearch approachBlack menSocial restrictionsHealth treatmentSuboptimal supportRecovery experiencesQualitative analysisThemesHigh-risk populationInterviewsHospital Variation in Geriatric Surgical Safety for Emergency Operation
Becher RD, Sukumar N, DeWane MP, Stolar MJ, Gill TM, Schuster KM, Maung AA, Zogg CK, Davis KA. Hospital Variation in Geriatric Surgical Safety for Emergency Operation. Journal Of The American College Of Surgeons 2020, 230: 966-973.e10. PMID: 32032720, PMCID: PMC7409563, DOI: 10.1016/j.jamcollsurg.2019.10.018.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioHospital-level characteristicsGeneral surgery operationsGeriatric patientsEmergency operationHospital variationEmergency general surgery operationsMean standardized mortality ratioCalifornia State Inpatient DatabaseHospital-based mortalitySignificant hospital variationPatients 65 yearsSubstantial excess mortalitySurgery operationsState Inpatient DatabasesMixed effects logistic regression modelsCommon general surgery operationsLow-mortality outliersLogistic regression modelsPostoperative mortalityHospital deathOlder patientsInpatient DatabaseMortality outcomesNonelective operations
2013
Pneumatosis Intestinalis Predictive Evaluation Study (PIPES)
DuBose JJ, Lissauer M, Maung AA, Piper GL, O’Callaghan T, Luo-Owen X, Inaba K, Okoye O, Shestopalov A, Fielder WD, Ferrada P, Wilson A, Channel J, Moore FO, Paul DB, Johnson S. Pneumatosis Intestinalis Predictive Evaluation Study (PIPES). Journal Of Trauma And Acute Care Surgery 2013, 75: 15-23. PMID: 23778433, DOI: 10.1097/ta.0b013e318298486e.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAgedAnalysis of VarianceCause of DeathCohort StudiesCombined Modality TherapyDigestive System Surgical ProceduresFemaleHospital MortalityHumansIncidenceLogistic ModelsMaleMiddle AgedPneumatosis Cystoides IntestinalisPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionSocieties, MedicalSurvival AnalysisTomography, X-Ray ComputedConceptsPathologic pneumatosis intestinalisPneumatosis intestinalisClinical prediction ruleIndependent predictorsPrediction ruleAcute renal failureRetrospective multicenter studySmall retrospective seriesStrong independent predictorRegression tree analysisAbsent bowelVasopressor needVasopressor useRenal failurePrimary outcomeClinical presentationRetrospective seriesBenign diseaseMechanical ventilationMulticenter studyTransmural ischemiaCase reportMedical historyClinical significanceProspective validation
2012
Compared to conventional ventilation, airway pressure release ventilation may increase ventilator days in trauma patients
Maung AA, Schuster KM, Kaplan LJ, Ditillo MF, Piper GL, Maerz LL, Lui FY, Johnson DC, Davis KA. Compared to conventional ventilation, airway pressure release ventilation may increase ventilator days in trauma patients. Journal Of Trauma And Acute Care Surgery 2012, 73: 507-510. PMID: 23019679, DOI: 10.1097/ta.0b013e31825ff653.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedContinuous Positive Airway PressureCritical CareDatabases, FactualFemaleFollow-Up StudiesHumansInjury Severity ScoreIntra-Abdominal HypertensionLength of StayLinear ModelsMaleMiddle AgedMultivariate AnalysisPulmonary Gas ExchangeRespiration, ArtificialRetrospective StudiesRisk AssessmentSurvival RateTime FactorsTrauma CentersTreatment OutcomeVentilator WeaningWounds and InjuriesConceptsAirway pressure release ventilationTotal ventilator daysVentilator daysHospital complicationsMechanical ventilationAIS scoreChest Abbreviated Injury Scale scoreAbbreviated Injury Scale scoreSpontaneous breathing trialAbdominal compartment syndromeAcute lung injuryAcute renal failureInjury Scale scoreStudy entry criteriaInjury Severity ScorePotential confounding factorsAPRV groupAPRV modeBreathing trialRescue therapyCompartment syndromeLung injuryRenal failureIndependent predictorsRetrospective reviewLessons learned from airway pressure release ventilation
Maung AA, Luckianow G, Kaplan LJ. Lessons learned from airway pressure release ventilation. Journal Of Trauma And Acute Care Surgery 2012, 72: 624-628. PMID: 22491545, DOI: 10.1097/ta.0b013e318247668f.Peer-Reviewed Original ResearchConceptsAirway pressure release ventilationPercent of patientsIntensive care unitMean timeVentilator strategiesCare unitMinute ventilationUniversity hospital surgical intensive care unitCO2 clearanceSurgical intensive care unitHypercarbic respiratory failurePressure-targeted modesPressure-targeted ventilationVentilator-associated complicationsSingle institution experienceLower minute ventilationMean minute ventilationBag-valve ventilationUnpaired t-testRespiratory failureCardiac surgeryInstitution experienceVascular surgeryLaboratory valuesHypoxemia
2011
Risk of Venous Thromboembolism After Spinal Cord Injury: Not All Levels Are the Same
Maung AA, Schuster KM, Kaplan LJ, Maerz LL, Davis KA. Risk of Venous Thromboembolism After Spinal Cord Injury: Not All Levels Are the Same. Journal Of Trauma And Acute Care Surgery 2011, 71: 1241-1245. PMID: 22071925, DOI: 10.1097/ta.0b013e318235ded0.Peer-Reviewed Original ResearchConceptsLevel of SCISpinal cord injuryRate of VTEIndependent risk factorVenous thromboembolismRisk factorsHospital complicationsSpine injuriesCord injuryHigh thoracic spinal cord injuryHigh cervical spine injuryLikelihood of VTENational Trauma Data BankThoracic spinal cord injuryMultiple logistic regression modelException of pneumoniaHigh thoracic injuriesInjury Severity ScoreThoracic spine injuriesCervical spine injuryDeep vein thrombosisHigh cervical injuriesTrauma Data BankMultiple risk factorsTraumatic brain injuryRoutine or Protocol Evaluation of Trauma Patients With Suspected Syncope is Unnecessary
Maung AA, Kaplan LJ, Schuster KM, Johnson DC, Davis KA. Routine or Protocol Evaluation of Trauma Patients With Suspected Syncope is Unnecessary. Journal Of Trauma And Acute Care Surgery 2011, 70: 428-432. PMID: 21307745, DOI: 10.1097/ta.0b013e31820958be.Peer-Reviewed Original ResearchConceptsDiagnostic workupCardiac enzymesSyncope workupAbnormal resultsStudy entry criteriaInjury Severity ScoreCause of injuryMotor vehicle collisionsSignificant abnormal resultsStandardized workupRetrospective reviewTrauma patientsCarotid duplexPhysical examinationSeverity scoreTomography angiographyEntry criteriaFemale genderFurther interventionClinical informationLevel ISyncopePatientsSubsequent interventionsWorkup
2008
Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function
Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function. The Journal Of Immunology 2008, 180: 2450-2458. PMID: 18250454, DOI: 10.4049/jimmunol.180.4.2450.Peer-Reviewed Original ResearchConceptsBurn-injured miceSham miceCecal ligationEnhanced innate immune responseSystemic inflammatory response syndromeInnate immune system functionRelevant sepsis modelSham-injured miceInflammatory response syndromeMac-1 expressionEscherichia coli infectionInnate immune responseSite of infectionImmune system functionPolymicrobial sepsisResponse syndromeOpportunistic infectionsSepsis modelDays postinjuryInjury causesColi infectionImmune responseCommon pathogensMajor injuriesAnimal studies
2006
Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity
MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA. Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity. Annals Of Surgery 2006, 124: 179-188. PMID: 16998360, PMCID: PMC1856576, DOI: 10.1097/01.sla.0000239031.06906.1f.Peer-Reviewed Original ResearchConceptsCD4 T cellsT cell proliferationT cellsDay 1IL-10IFNgamma productionDay 7Inhibitory cytokine IL-10Patient CD4 T cellsCD4 T cell proliferationCD3/CD28 antibodiesTh1-type immunityCytokine IL-10Regulatory cell activityTh1 cytokine productionCytometric bead arrayT Regulatory Cell ActivityTh2-type cytokinesProtective Th1 immunityCell proliferationT cell activationActivation of cellsIncreased CD4Treg activityTreg suppression
2005
Enhanced TLR4 reactivity following injury is mediated by increased p38 activation
Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. Journal Of Leukocyte Biology 2005, 78: 565-573. PMID: 15857937, DOI: 10.1189/jlb.1204698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBurnsCells, CulturedEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationImidazolesLipopolysaccharidesMacrophagesMaleMembrane GlycoproteinsMiceMyoD ProteinProtein KinasesPyridinesReceptors, Cell SurfaceSignal TransductionSpleenToll-Like Receptor 4Toll-Like ReceptorsConceptsMitogen-activated protein kinaseExtracellular signal-regulated kinaseStress-activated protein kinaseP38 activationJun N-terminal kinase (JNK) mitogen-activated protein kinaseProtein kinaseKinase mitogen-activated protein kinaseSAPK/JNK activationProtein-2 proteinTLR4 reactivitySham miceSpecific p38 inhibitorSignal-regulated kinaseInterleukin-1 receptor-associated kinaseDay 1Receptor-associated kinaseMyeloid differentiation primary response protein 88Tumor necrosis factor-alpha productionToll-like receptor 4Necrosis factor-alpha productionCell surface expressionTLR4 mRNA expressionInjury-induced increaseProinflammatory cytokine productionInjury-induced changes
1999
Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair
QUINN T, MAUNG A, GRODZINSKY A, HUNZIKER E, SANDY J. Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair. Annals Of The New York Academy Of Sciences 1999, 878: 420-441. PMID: 10415746, DOI: 10.1111/j.1749-6632.1999.tb07700.x.Peer-Reviewed Original ResearchConceptsInjurious compressionProteoglycan turnoverIL-1 betaCartilage explantsQuantitative autoradiographyClinical strategiesCartilage injuryMatrix metabolismMatrix degradationProteoglycan depositionTissue degradationBiomechanical pathwaysCell-associated matrixBiomechanical rolePossible new approachCartilage repair strategiesViable chondrocytesAdult bovineChondrocytesCartilage repairChondrocyte phenotypeRepairPG degradationExtracellular matrixCatabolic process