Enhanced TLR4 reactivity following injury is mediated by increased p38 activation
Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. Journal Of Leukocyte Biology 2005, 78: 565-573. PMID: 15857937, DOI: 10.1189/jlb.1204698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBurnsCells, CulturedEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationImidazolesLipopolysaccharidesMacrophagesMaleMembrane GlycoproteinsMiceMyoD ProteinProtein KinasesPyridinesReceptors, Cell SurfaceSignal TransductionSpleenToll-Like Receptor 4Toll-Like ReceptorsConceptsMitogen-activated protein kinaseExtracellular signal-regulated kinaseStress-activated protein kinaseP38 activationJun N-terminal kinase (JNK) mitogen-activated protein kinaseProtein kinaseKinase mitogen-activated protein kinaseSAPK/JNK activationProtein-2 proteinTLR4 reactivitySham miceSpecific p38 inhibitorSignal-regulated kinaseInterleukin-1 receptor-associated kinaseDay 1Receptor-associated kinaseMyeloid differentiation primary response protein 88Tumor necrosis factor-alpha productionToll-like receptor 4Necrosis factor-alpha productionCell surface expressionTLR4 mRNA expressionInjury-induced increaseProinflammatory cytokine productionInjury-induced changes