2023
The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS
Alemany-Navarro M, Tubío-Fungueiriño M, Almeida S, Cruz R, Lombroso A, Real E, Soria V, Bertolín S, Fernández-Prieto M, Alonso P, Menchón J, Carracedo A, Segalàs C. The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS. Journal Of Affective Disorders 2023, 333: 365-376. PMID: 37094658, DOI: 10.1016/j.jad.2023.04.060.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide polymorphismsSuggestive signalsCase/control genome-wide association studyPreliminary genome-wide association studyGenome-wide levelGenome-wide significanceGenomic basisComplex traitsGenomic regionsWhole genomeGenetic basisAssociation studiesGenetic characterizationAssociation of SNPsNucleotide polymorphismsGenomicsTraitsGenomeGenesNeuropsychological traitsPolymorphismPromising avenueSignalsOCD cases
2021
Genomics of Obsessive-Compulsive Disorder—Toward Personalized Medicine in the Era of Big Data
Szejko N, Dunalska A, Lombroso A, McGuire JF, Piacentini J. Genomics of Obsessive-Compulsive Disorder—Toward Personalized Medicine in the Era of Big Data. Frontiers In Pediatrics 2021, 9: 685660. PMID: 34746045, PMCID: PMC8564378, DOI: 10.3389/fped.2021.685660.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumCommon disease-common variant hypothesisCommon variant hypothesisContext of genomicsGenetic codeGenetic association studiesMultiple genesAssociation studiesGenomics ConsortiumPolygenic risk scoresGenomicsGenetic contributionMendelian randomizationPolygenic disorderPersonalized medicineObsessive-compulsive disorderUK BiobankNew pathwayOCD pathogenesisAvailable databasesGenesDisease-specific databasesChina Kadoorie BiobankPathwayCo-existing pathology