TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma
Mosrati M, Malmström A, Lysiak M, Krysztofiak A, Hallbeck M, Milos P, Hallbeck A, Bratthäll C, Strandéus M, Stenmark-Askmalm M, Söderkvist P. TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma. Oncotarget 2015, 6: 16663-16673. PMID: 26143636, PMCID: PMC4599297, DOI: 10.18632/oncotarget.4389.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsShorter overall survivalOverall survivalPromoter mutationsC228TInterleukin-6 expressionPrimary glioblastoma patientsTypes of tumorsReverse transcriptase activityPrognostic factorsShorter survivalIL-6GBM patientsTERT promoter statusGlioblastoma patientsHomozygous carriersC alleleTumours leadsC250TPrimary glioblastomaPromoter statusTERT promoterMinor alleleGlioblastomaTranscriptase activity