Featured Publications
Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic
Sharma R, Kuohn LR, Weinberger DM, Warren JL, Sansing LH, Jasne A, Falcone G, Dhand A, Sheth KN. Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic. Stroke 2021, 52: 563-572. PMID: 33430638, PMCID: PMC7834664, DOI: 10.1161/strokeaha.120.031975.Peer-Reviewed Original ResearchConceptsEmergency medical servicesCerebrovascular deathCOVID-19 deathsCerebrovascular mortalityCOVID-19 pandemicStroke-related deathCoronavirus disease 2019 (COVID-19) pandemicFirst COVID-19 deathDisease 2019 pandemicPublic health measuresHealth Statistics dataPoisson regression modelsCumulative COVID-19 deathsAcute strokeStroke deathsVascular pathologyEMS callsMedical careHealth measuresNew York CityMortalityDeathMedical servicesWeeksRegression analysisCerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome
Jasne AS, Alsherbini KH, Smith MS, Pandhi A, Vagal A, Kanter D. Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome. Neurocritical Care 2019, 31: 288-296. PMID: 30788708, PMCID: PMC6757017, DOI: 10.1007/s12028-018-00666-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholic IntoxicationAmphetaminesBasal GangliaBenzodiazepinesBrain EdemaCentral Nervous System StimulantsCerebellar CortexCerebellumCocaineComaFemaleHeroinHippocampusHumansHydrocephalusHydromorphoneMagnetic Resonance ImagingMaleMiddle AgedOpiate AlkaloidsPain, PostoperativeStuporSubstance-Related DisordersSyndromeConceptsCerebellar edemaIschemic strokeObstructive hydrocephalusCerebellar cortexAcute cytotoxic edemaSeries of patientsNeurocritical care unitPatterns of injuryLevel of consciousnessMagnetic resonance imagingClinical characteristicsInitial presentationCare unitSurgical managementHypoxic injuryCytotoxic edemaFavorable outcomeSimilar presentationAnoxic injuryBilateral hippocampusTransient edemaBasal nucleusToxic injuryNovel syndromeAcceptable outcomesStroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic
Jasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic. Stroke 2020, 51: 2664-2673. PMID: 32755347, PMCID: PMC7446978, DOI: 10.1161/str.0000000000000347.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusBrain IschemiaCohort StudiesComorbidityConnecticutCoronary Artery DiseaseCoronavirus InfectionsCOVID-19DyslipidemiasEmergency Medical ServicesEthnicityFemaleHumansHypertensionIncomeInsurance, HealthIntracranial HemorrhagesMaleMedically UninsuredMiddle AgedOutcome and Process Assessment, Health CarePandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2Severity of Illness IndexStrokeSubstance-Related DisordersTelemedicineThrombectomyThrombolytic TherapyTime-to-TreatmentConceptsComprehensive stroke centerStroke codePatient characteristicsStroke severityStroke code patientsHistory of hypertensionStroke-like symptomsCoronary artery diseaseCoronavirus disease 2019 (COVID-19) pandemicPatient-level dataLower median household incomePublic health initiativesDisease 2019 pandemicCOVID-19 pandemicRace/ethnicityCode patientsHospital presentationPublic health insuranceRankin ScaleStroke centersArtery diseaseReperfusion timeStroke symptomsEarly outcomesConnecticut hospitals
2024
Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanTemporal Trends and Racial Disparities in Long-Term Survival After Stroke
Robinson D, Ding L, Howard G, Stanton R, Khoury J, Sucharew H, Haverbusch M, Nobel L, Khatri P, Adeoye O, Broderick J, Ferioli S, Mackey J, Woo D, Rios La Rosa F, Flaherty M, Slavin S, Star M, Martini S, Demel S, Walsh K, Coleman E, Jasne A, Mistry E, Kleindorfer D, Kissela B. Temporal Trends and Racial Disparities in Long-Term Survival After Stroke. Neurology 2024, 103: e209653. PMID: 39008784, PMCID: PMC11249510, DOI: 10.1212/wnl.0000000000209653.Peer-Reviewed Original ResearchConceptsPremorbid functional statusFunctional statusRacial disparitiesAcute ischemic strokeBlack individualsPopulation-based stroke studyBlack raceEffect of black raceNational Death IndexAssociated with 5-year mortalityBaseline functional statusAcute ischemic stroke casesRisk of deathPhysician adjudicationIntracerebral hemorrhageDeath IndexIntracerebral hemorrhage casesUS populationICD codesGeneral populationCalendar yearLogistic regressionModified Rankin ScaleStroke StudyMedical recordsImpact of Poverty on Stroke Recurrence: A Population-Based Study.
Becker C, Sucharew H, Robinson D, Stamm B, Royan R, Nobel L, Stanton R, Jasne A, Woo D, De Los Rios La Rosa F, Mackey J, Ferioli S, Mistry E, Demel S, Haverbusch M, Coleman E, Slavin S, Walsh K, Star M, Flaherty M, Martini S, Kissela B, Kleindorfer D. Impact of Poverty on Stroke Recurrence: A Population-Based Study. Neurology 2024, 102: e209423. PMID: 38759136, PMCID: PMC11175648, DOI: 10.1212/wnl.0000000000209423.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic statusPopulation-based studyIncident strokeCensus tractsSecondary analysisGreater Cincinnati/Northern Kentucky regionStroke recurrencePoisson regression modelsPoverty lineFederal poverty lineRecurrent strokeRecurrence riskVascular risk factorsResidents of poor neighborhoodsStudy periodAmerican Community SurveyNeighborhood povertySocioeconomic statusExcess riskStroke incidenceImpact of povertyPrimary exposureRelative riskStroke recurrence riskWhite individualsRacial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study
Aziz Y, Sucharew H, Stanton R, Alwell K, Ferioli S, Khatri P, Adeoye O, Flaherty M, Mackey J, La Rosa F, Martini S, Mistry E, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Ridha M, Ades L, Haverbusch M, Demel S, Woo D, Kissela B, Kleindorfer D. Racial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study. Journal Of The American Heart Association 2024, 13: e032645. PMID: 38700029, PMCID: PMC11179936, DOI: 10.1161/jaha.123.032645.Peer-Reviewed Original ResearchConceptsNational Institutes of Health Stroke Scale scoreWhite patientsStroke Scale scoreAcute ischemic strokeBlood pressureGreater Cincinnati/Northern Kentucky Stroke StudyDiastolic BPBlack patientsPopulation-based studyStudy epochInfluence clinical decision-makingScale scoreStroke risk factorsPresenting blood pressureIschemic strokeSubanalysis of patientsBody mass indexNational InstituteHistory of hypertensionMultivariate linear regressionClinical trial eligibilityAcute ischemic stroke presentingClinical decision-makingIschemic stroke presentingRacial disparitiesMigration of Iophendylate Myelography Contrast to the Brain With Successful Thrombectomy.
Tu L, Hegde R, Prust M, Mageid R, Hebert R, Jasne A. Migration of Iophendylate Myelography Contrast to the Brain With Successful Thrombectomy. Neurology 2024, 102: e209314. PMID: 38547442, DOI: 10.1212/wnl.0000000000209314.Peer-Reviewed Original ResearchHealth Factors Associated With Development and Severity of Poststroke Dysphagia: An Epidemiological Investigation
Krekeler B, Schieve H, Khoury J, Ding L, Haverbusch M, Alwell K, Adeoye O, Ferioloi S, Mackey J, Woo D, Flaherty M, La Rosa F, Demel S, Star M, Coleman E, Walsh K, Slavin S, Jasne A, Mistry E, Kleindorfer D, Kissela B. Health Factors Associated With Development and Severity of Poststroke Dysphagia: An Epidemiological Investigation. Journal Of The American Heart Association 2024, 13: e033922. PMID: 38533959, PMCID: PMC11179757, DOI: 10.1161/jaha.123.033922.Peer-Reviewed Original ResearchConceptsHistory of high cholesterolDysphagia statusLogistic regressionFactors associated with reduced riskHealth risk factorsPopulation-based studyFactors associated with increased riskNational Institutes of Health Stroke Scale scoreMultivariate logistic regressionRisk of dysphagiaPoststroke dysphagiaHemorrhagic stroke casesStroke Scale scoreStroke casesDevelopment of dysphagiaStroke recoveryPercutaneous endoscopic gastrostomy tube placementBlack raceRight hemisphere strokeHemorrhagic strokeHigh cholesterolRisk factorsAcute strokeFactors associated with developmentChart reviewMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke
Benali F, Singh N, Fladt J, Jaroenngarmsamer T, Bala F, Ospel J, Buck B, Dowlatshahi D, Field T, Hanel R, Peeling L, Tymianski M, Hill M, Goyal M, Ganesh A, Barber P, Smith E, Bal S, Subramanian S, Peters S, Couillard P, Klein G, Stys P, Coutts S, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Kashani N, Venkatesan P, Teleg E, Sitaram A, Graham B, Gaal S, Moussaddy A, Chakraborty D, Maraj N, Lockey A, Chen S, Singh R, Alsultan A, Asunsian R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Ower R, Ashforth R, Yeo T, Kotylak T, O;Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Roy D, Deneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farinas C, Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariépy J, Collard K, Haché A, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, Sa Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattai A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Yaher N, Vandervelde C, Wang D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Manosalva Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Frei D, Bellon R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, DePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Glichrist V, Feineigle P, Toseki Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Anne Y. Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Haas R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossber J, Craft L, Schindler K, Schaad E, Schultz M, Sutherly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, DukSoo Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, DeMacedo Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kouhn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Kelly D, Gupta R, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Hoe Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shan D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, dos Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Drew R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Moreira T, Sjöstrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thorén M, Keselman B, Ahmed N, Holmberg Å, Axelsson M, Berglund A, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Müller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Müller N, Weber R, Veltkamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Beyrle E, Beck P, Möhlenbruch M. Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke. JAMA Network Open 2024, 7: e2349628. PMID: 38165676, PMCID: PMC10762575, DOI: 10.1001/jamanetworkopen.2023.49628.Peer-Reviewed Original ResearchConceptsMarker of frailtyEndovascular thrombectomyAlteplase treatmentCohort studyESCAPE-NA1 trialAcute ischemic strokeEarly ischemic changesSmall vessel diseaseBest medical managementAcute care hospitalsBrain frailtyFrailty featuresIschemic strokeStroke severityBrain atrophyCare hospitalIschemic changesPrimary outcomeClinical featuresMedical managementPuncture timeThrombectomy outcomesPoor outcomeVessel diseaseFunctional outcome
2023
Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke
Forman R, Okumu R, Mageid R, Baker A, Neu D, Parker R, Peyravi R, Schindler J, Sansing L, Sheth K, de Havenon A, Jasne A, Narula R, Wira C, Warren J, Sharma R. Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke. Neurology 2023, 102: e207764. PMID: 38165368, PMCID: PMC10834135, DOI: 10.1212/wnl.0000000000207764.Peer-Reviewed Original ResearchConceptsEmergency department arrival timesEmergency medical servicesLate presentationAcute ischemic stroke therapyYale-New Haven HospitalGuidelines-Stroke registryNeighborhood-level socioeconomic factorsPatient-level factorsRetrospective observational studyIschemic stroke therapyMixed-effects logistic regression modelNon-white patientsNon-white raceUnivariate logistic regressionNew Haven HospitalLogistic regression modelsHospital presentationTreatment ineligibilityStroke RegistryAcute strokeHospital arrivalStroke therapyUnivariate analysisObservational studyPatientsTrends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study
Vagal A, Sucharew H, Wang L, Kissela B, Alwell K, Haverbusch M, Woo D, Ferioli S, Mackey J, La Rosa F, Mistry E, Demel S, Coleman E, Jasne A, Walsh K, Khatri P, Slavin S, Star M, Stephens C, Kleindorfer D. Trends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study. Stroke 2023, 54: 1001-1008. PMID: 36972349, DOI: 10.1161/strokeaha.122.040790.Peer-Reviewed Original ResearchConceptsPopulation-based studyAdvanced imagingSocioeconomic statusAcute strokeOlder patientsAdvanced neuroimagingStroke/transient ischemic attack eventsTransient ischemic attack eventsUS census tractsTransient ischemic attackLow SES patientsMultivariable logistic regressionHospital admission dateHigher socioeconomic statusIschemic attackYounger patientsSES patientsWhite patientsBlack patientsAdmission dateMultivariable modelAttack onsetSES-related disparitiesPatientsSecondary objectiveChanging Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015
Ridha M, Flaherty M, Aziz Y, Ades L, Alwell K, Khoury J, Woo D, Ferioli S, Adeoye O, Khatri P, De Los Rios La Rosa F, Mistry E, Demel S, Mackey J, Martini S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Madsen T, Broderick J, Kissela B, Kleindorfer D. Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015. Neurology 2023, 100: e1555-e1564. PMID: 36746635, PMCID: PMC10103121, DOI: 10.1212/wnl.0000000000206865.Peer-Reviewed Original ResearchConceptsRisk factorsOpioid epidemicClinical characteristicsClinical featuresGreater Cincinnati/Northern Kentucky regionStudy periodRetrospective cohort studyRates of hypertensionIntravenous drug useIntravenous drug usersICD-10 codesCochran-Armitage testPerioperative strokeAcute strokeCohort studyDefinite endocarditisDuke criteriaHypertension prevalenceIschemic strokeYounger patientsStroke populationInfective endocarditisAtrial fibrillationEpidemiologic descriptionUnadjusted comparisons
2022
Navigating an Internal Carotid Artery Anatomic Variant During Endovascular Therapy for Acute Ischemic Stroke
Peng T, Sharma R, Antonios J, Hebert R, Jasne A. Navigating an Internal Carotid Artery Anatomic Variant During Endovascular Therapy for Acute Ischemic Stroke. Stroke 2022, 53: e517-e518. PMID: 36106549, DOI: 10.1161/strokeaha.122.040501.Peer-Reviewed Case Reports and Technical NotesRacial Disparities in Stroke Recurrence
Robinson DJ, Stanton R, Sucharew H, Alwell K, Haverbusch M, De Los Rios La Rosa F, Ferioli S, Coleman E, Jasne A, Mackey J, Star M, Mistry EA, Demel S, Slavin S, Walsh K, Woo D, Kissela B, Kleindorfer DO. Racial Disparities in Stroke Recurrence. Neurology 2022, 99: e2464-e2473. PMID: 36041865, PMCID: PMC9728039, DOI: 10.1212/wnl.0000000000201225.Peer-Reviewed Original ResearchConceptsTraditional stroke risk factorsStroke risk factorsRisk factorsBlack raceRecurrent strokeStroke recurrenceRecurrence rateHigh riskGreater Cincinnati/Northern Kentucky populationBlack individualsStroke/TIA eventsRacial disparitiesStroke recurrence rateMultivariable survival analysisRisk of recurrenceKaplan-Meier estimatesSignificant racial disparitiesTIA eventsIncident strokeSmoking statusVentricular hypertrophyStroke casesRecurrenceSurvival analysisYounger age
2021
Expedited and Comprehensive Management of Low-Risk TIA Patients in the Emergency Department is Safe and Less Costly
Garg A, Maran I, Amin H, Vlieks K, Neuschatz K, Coppola A, Poskus K, Johnson J, Davis M, Minja F, Schindler J, Sansing LH, Malhotra A, Jasne AS, Sharma R. Expedited and Comprehensive Management of Low-Risk TIA Patients in the Emergency Department is Safe and Less Costly. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 106016. PMID: 34325273, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overClinical ProtocolsCost SavingsCost-Benefit AnalysisDecision Support TechniquesDelivery of Health Care, IntegratedEmergency Service, HospitalFeasibility StudiesFemaleHospital CostsHumansIschemic Attack, TransientLength of StayMaleMiddle AgedOutcome and Process Assessment, Health CarePredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeTriageConceptsLow-risk TIA patientsTransient ischemic attackTIA patientsEmergency roomAcademic comprehensive stroke centerSingle-center cohort studyPre-pathway groupComprehensive stroke centerClinical practice recommendationsLength of stayOutcomes of interestImpending strokeIschemic attackOutpatient echocardiogramRapid outpatientTIA admissionsEchocardiogram findingsEchocardiographic findingsStroke clinicCohort studyStroke centersNeurovascular eventsEmergency departmentFinal diagnosisHospital costs
2017
Contributors to the Excess Stroke Mortality in Rural Areas in the United States
Howard G, Kleindorfer DO, Cushman M, Long DL, Jasne A, Judd SE, Higginbotham JC, Howard VJ. Contributors to the Excess Stroke Mortality in Rural Areas in the United States. Stroke 2017, 48: 1773-1778. PMID: 28626048, PMCID: PMC5502731, DOI: 10.1161/strokeaha.117.017089.Peer-Reviewed Original ResearchConceptsHigh case fatalityCase fatalityStroke mortalityRisk factorsStroke incidenceSocioeconomic statusTraditional stroke risk factorsIncident stroke riskStroke risk factorsProportional hazards analysisHigher stroke incidenceStroke-free participantsUrban-rural statusHigher stroke mortalityLow socioeconomic statusRural-urban statusExcess stroke mortalityIncident strokeStroke riskREGARDS studyHigh prevalenceHigh incidenceRural areasLogistic regressionSmall rural town