2022
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA
Wong KH, Muddasani V, Peterson C, Sheibani N, Arkin C, Cheong I, Majersik JJ, Biffi A, Petersen N, Falcone GJ, Sansing LH, de Havenon AH. Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA. American Journal Of Hypertension 2022, 36: 144-147. PMID: 36315490, PMCID: PMC11484580, DOI: 10.1093/ajh/hpac122.Peer-Reviewed Original ResearchConceptsBlood pressure variabilityHigh blood pressure variabilitySerum inflammatory markersPlasmin-antiplasmin complexC-reactive proteinInterleukin-6Inflammatory markersBlood pressureStudy visitPressure variabilityBaseline serum IL-6Visit blood pressure variabilityLipid-lowering medicationsMean blood pressureSerum IL-6Markers of inflammationSystolic blood pressureBaseline study visitBody mass indexOnly IL-6Major vascular diseasesMulti-Ethnic StudyBaseline serum biomarkersPatient age categoryPost Hoc AnalysisStatin Usage Increases White Matter Hyperintensities
Goldstein ED, Garg G, Navarro K, Wolcott Z, Yaghi S, Wong KH, McLean K, de Havenon AH. Statin Usage Increases White Matter Hyperintensities. The Neurologist 2022, 28: 94-98. PMID: 35680399, DOI: 10.1097/nrl.0000000000000448.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesWMH progressionStatin usageTop tertileRisk factorsMatter hyperintensitiesWMH volumeConventional cerebrovascular risk factorsProgression of WMHCerebral small vessel diseaseInfluence of dyslipidemiaCerebrovascular risk factorsInfluence of statinsBaseline WMH volumeSmall vessel diseaseSynergistic risk factorsLow-density lipoproteinFull therapyStatin useVessel diseaseStudy visitWMH developmentPartial therapyWMH dataReductase inhibitors
2021
Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study
de Havenon A, Delic A, Stulberg E, Sheibani N, Stoddard G, Hanson H, Theilen L. Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study. JAMA Network Open 2021, 4: e215077. PMID: 33900402, PMCID: PMC8076961, DOI: 10.1001/jamanetworkopen.2021.5077.Peer-Reviewed Original ResearchConceptsHistory of preeclampsiaVascular risk factorsIncident strokeRisk factorsFramingham Heart StudyMarginal structural modelsCohort studyStroke incidenceRelative riskHeart StudyLater lifeTime-varying covariatesMidlife vascular risk factorsPopulation-based cohort studyHigher diastolic blood pressureAbsence of preeclampsiaCholesterol-lowering medicationsDiastolic blood pressureAge 45 yearsAssociation of preeclampsiaBlood pressureMore pregnanciesStudy visitPreeclampsiaMAIN OUTCOME