2024
Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions
Al Kasab S, Nguyen T, Derdeyn C, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat O, de Havenon A. Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions. Stroke 2024, 55: 355-365. PMID: 38252763, DOI: 10.1161/strokeaha.123.043635.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisVessel occlusionRecurrence riskEarly recurrence riskHigh-risk patientsAggressive medical managementRecurrent stroke riskEndovascular therapyHemodynamic failureTreatment strategiesPerfusion imagingAdvanced ageEndovascular interventionIntracranial stenosisMedical managementRisk factorsHigh riskAdvanced imagingAtherosclerotic stenosisStroke riskOcclusionStenosisPatientsRisk
2021
EP31* Vessel wall MRI findings improve specificity for detection of delayed in-stent stenosis following flow diversion of unruptured aneurysms
Alexander M, Costello J, McNally J, de Havenon A, Grandhi R. EP31* Vessel wall MRI findings improve specificity for detection of delayed in-stent stenosis following flow diversion of unruptured aneurysms. Journal Of NeuroInterventional Surgery 2021, 13: a13-a13. DOI: 10.1136/neurintsurg-2021-esmint.31.Peer-Reviewed Original ResearchSubsequent digital subtraction angiographyDigital subtraction angiographyVessel wall MRIStent stenosisUnruptured aneurysmsExact testExact logistic regression analysisIntracranial vascular pathologyLogistic regression analysisFisher's exact testUnruptured intracranial aneurysmsFlow diverter treatmentFlow diverter implantationBlack-blood sequenceMRI findingsMultivariable analysisCommon findingStudy groupVascular pathologyStenosisBlood sequenceCerebral aneurysmsDiverter treatmentAneurysmsIntracranial aneurysmsCarotid Stenosis and Recurrent Ischemic Stroke
Yaghi S, de Havenon A, Rostanski S, Kvernland A, Mac Grory B, Furie KL, Kim AS, Easton JD, Johnston SC, Henninger N. Carotid Stenosis and Recurrent Ischemic Stroke. Stroke 2021, 52: 2414-2417. PMID: 33940954, PMCID: PMC8268075, DOI: 10.1161/strokeaha.121.034089.Peer-Reviewed Original ResearchConceptsHigh-risk transient ischemic attackTransient ischemic attackEffect of clopidogrelMinor ischemic strokeIschemic strokeIschemic stroke riskCarotid stenosisIschemic attackStroke riskCervical internal carotid arteryAddition of clopidogrelDual antiplatelet therapyRecurrent ischemic strokeCox regression modelInternal carotid arteryAntiplatelet therapyPrimary outcomePoint trialCarotid arteryInclusion criteriaClopidogrelAdjusted modelStenosisPatientsStrokeEndothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease
Liebeskind DS, Hinman JD, Kaneko N, Kitajima H, Honda T, De Havenon AH, Feldmann E, Nogueira RG, Prabhakaran S, Romano JG, Callas PW, Schneider DJ. Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease. Frontiers In Neurology 2021, 12: 646309. PMID: 33716947, PMCID: PMC7947292, DOI: 10.3389/fneur.2021.646309.Peer-Reviewed Original ResearchIntracranial atherosclerotic diseaseEndothelial shear stressFcγRIIa expressionAtherosclerotic diseaseFcγRIIA receptorsArterial stenosisAnti-platelet medicationAnti-platelet strategiesPotent risk factorLocal pathophysiologyRecurrent strokeRisk factorsCardiovascular diseaseVascular remodelingIndividual patientsPlaque growthPlatelet activationElevated expressionDiseasePlatelet interactionClinical realmRecurrent eventsStenosisDifferential activationLuminal wallOptimal Carotid Plaque Features on Computed Tomography Angiography Associated With Ischemic Stroke
Baradaran H, Eisenmenger LB, Hinckley PJ, de Havenon AH, Stoddard GJ, Treiman LS, Treiman GS, Parker DL, McNally J. Optimal Carotid Plaque Features on Computed Tomography Angiography Associated With Ischemic Stroke. Journal Of The American Heart Association 2021, 10: e019462. PMID: 33586471, PMCID: PMC8174260, DOI: 10.1161/jaha.120.019462.Peer-Reviewed Original ResearchConceptsMaximum soft plaque thicknessPlaque thicknessIntraluminal thrombusRim signIschemic strokeStroke sourcesPlaque featuresCarotid plaquesMultivariable Poisson regression modelsDiscriminatory valueRetrospective cross-sectional studyVulnerable carotid plaquesCross-sectional studyCarotid plaque featuresSpecific plaque featuresPoisson regression modelsStroke prediction modelsCarotid sourceCarotid stenosisCarotid CTAImaging featuresStenosis categoriesClinical markersTreatment decisionsStenosis
2016
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA
Eisenmenger LB, Aldred BW, Kim S, Stoddard GJ, de Havenon A, Treiman GS, Parker DL, McNally JS. Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA. American Journal Of Neuroradiology 2016, 37: 1496-1503. PMID: 27102316, PMCID: PMC7960279, DOI: 10.3174/ajnr.a4765.Peer-Reviewed Original ResearchConceptsMaximum soft plaque thicknessCarotid intraplaque hemorrhageAdventitial calcificationIntraplaque hemorrhageRim signPlaque thicknessRetrospective cohort studyAtherosclerosis risk factorsMaximum plaque thicknessMultivariable Poisson regressionNASCET stenosisCohort studyAdventitial inflammationRisk factorsPlaque instabilityCarotid arteryHemorrhageUlcerationSoft plaqueStenosisIntraluminal thrombusPoisson regressionFinal modelCalcificationCarotid MRA