2022
Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy
Prasad A, Kobsa J, Kodali S, Bartolome D, Begunova L, Quispe-Orozco D, Farooqui M, Zevallos C, Ortega-Gutiérrez S, Anadani M, Almallouhi E, Spiotta A, Giles J, Keyrouz S, Kim J, Maier I, Liman J, Psychogios M, Riou-Comte N, Richard S, Gory B, Wolfe S, Brown P, Fargen K, Mistry E, Fakhri H, Mistry A, Wong K, Nascimento F, Kan P, de Havenon A, Sheth K, Petersen N. Temporal profiles of systolic blood pressure variability and neurologic outcomes after endovascular thrombectomy. European Stroke Journal 2022, 7: 365-375. PMID: 36478756, PMCID: PMC9720854, DOI: 10.1177/23969873221106907.Peer-Reviewed Original ResearchBlood pressure variabilitySystolic blood pressure variabilityHigh systolic blood pressure variabilityEndovascular thrombectomyFunctional outcomePressure variabilityHigh blood pressure variabilityLower blood pressure variabilityAcute ischemic stroke patientsLarge vessel occlusion strokePoor discharge outcomeIschemic stroke patientsWorse functional outcomePoor functional outcomeBlood pressure dataHigh trajectory groupGroup-based trajectory modelingHemorrhagic transformationNeurologic outcomeDischarge outcomesSBP trajectoriesStroke patientsOcclusion strokePoor outcomeRelevant confounders
2020
Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage
Menacho ST, Grandhi R, Delic A, Anadani M, Ziai WC, Awad IA, Hanley DF, de Havenon A. Impact of Intracranial Pressure Monitor–Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105540. PMID: 33360250, PMCID: PMC8080544, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105540.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Trials, Phase III as TopicDatabases, FactualFemaleHumansIntracranial HemorrhagesIntracranial PressureMaleMiddle AgedMonitoring, PhysiologicPredictive Value of TestsRandomized Controlled Trials as TopicRecovery of FunctionRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsICP monitor placementNontraumatic intracranial hemorrhageIntracranial hemorrhageIntracranial pressure monitorPoor outcomeNeurologic outcomePressure monitorPropensity score-matched cohortMonitor placementIdentification of patientsSpontaneous intracranial hemorrhageExternal ventricular drainInvasive ICP monitoringLogistic regression modelsIntraparenchymal monitorsIII trialsSecondary outcomesPrimary outcomeBalanced cohortVentricular drainICP monitorICP monitoringPatientsSecondary analysisGreater riskIntracerebral Hemorrhage Location Predicts Neurologic Outcome, Mortality, and End-of-Treatment Intracerebral Hemorrhage Volume After Minimally Invasive Evacuation
Joyce E, Deshmukh A, de Havenon A, Scoville J, Ansari S, Taussky P, Grandhi R. Intracerebral Hemorrhage Location Predicts Neurologic Outcome, Mortality, and End-of-Treatment Intracerebral Hemorrhage Volume After Minimally Invasive Evacuation. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_257.Peer-Reviewed Original Research
2019
Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy
Mistry EA, Mehta T, Mistry A, Arora N, Starosciak AK, De Los Rios La Rosa F, Siegler JE, Chitale R, Anadani M, Yaghi S, Khatri P, de Havenon A. Blood Pressure Variability and Neurologic Outcome After Endovascular Thrombectomy. Stroke 2019, 51: 511-518. PMID: 31813361, PMCID: PMC8010595, DOI: 10.1161/strokeaha.119.027549.Peer-Reviewed Original ResearchConceptsHigh blood pressure variabilityBlood pressure variabilitySystolic blood pressure variabilityEndovascular treatmentPoor outcomeStroke patientsPressure variabilityAnterior circulation acute ischemic stroke patientsLower systolic blood pressure variabilityMeasure of BPVAcute ischemic stroke patientsDiastolic blood pressure variabilityLogistic regressionLarge vessel occlusion strokeMulticenter cohort studyIschemic stroke patientsWorse functional outcomeRate of deathNeurologic outcomeNeurological outcomeCohort studyEndovascular thrombectomyDiastolic BPHighest tertileOcclusion strokeResponse by de Havenon et al to Letter Regarding Article, “Results From DEFUSE 3: Good Collaterals Are Associated With Reduced Ischemic Core Growth but Not Neurologic Outcome”
de Havenon A, Albers GW, Heit JJ. Response by de Havenon et al to Letter Regarding Article, “Results From DEFUSE 3: Good Collaterals Are Associated With Reduced Ischemic Core Growth but Not Neurologic Outcome”. Stroke 2019, 50: e166. PMID: 31084323, PMCID: PMC6538451, DOI: 10.1161/strokeaha.119.025713.Peer-Reviewed Original ResearchIncreased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive
de Havenon A, Stoddard G, Saini M, Wong KH, Tirschwell D, Bath P, . Increased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive. JRSM Cardiovascular Disease 2019, 8: 2048004019856496. PMID: 31217966, PMCID: PMC6560789, DOI: 10.1177/2048004019856496.Peer-Reviewed Original ResearchBlood pressure variabilityVirtual International Stroke Trials ArchiveAcute ischemic strokePressure variabilityIschemic strokeStudy enrollmentAcute ischemic stroke patientsDiastolic blood pressure variabilitySystolic blood pressure variabilityIschemic stroke patientsOutcome of deathWorse neurologic outcomeDiastolic blood pressureRisk of deathBlood pressure readingsLogistic regression modelsNeurologic outcomeRankin ScaleStroke onsetBlood pressurePrimary outcomeClinical outcomesStroke patientsRetrospective analysisLarge cohort
2018
Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome
Bennett AE, Wilder MJ, McNally JS, Wold JJ, Stoddard GJ, Majersik JJ, Ansari S, de Havenon A. Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome. Journal Of NeuroInterventional Surgery 2018, 10: 823. PMID: 29352059, DOI: 10.1136/neurintsurg-2017-013473.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleBlood pressure variabilityIntra-arterial therapyIntravenous tissue plasminogen activatorPressure variabilityTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsIschemic strokeWorse outcomesMean age 63.2 yearsMedian admission National InstitutesMultivariable ordinal logistic regression modelsSystolic blood pressure variabilityPlasminogen activatorAdmission National InstitutesWorse neurologic outcomeWorse clinical outcomesLogistic regression analysisOrdinal logistic regression analysisIndependent predictive abilitySuccessive variationAcute strokeEndovascular thrombectomyNeurologic outcome
2017
Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke
de Havenon A, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB. Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurology 2017, 74: 453-458. PMID: 28192548, PMCID: PMC5470363, DOI: 10.1001/jamaneurol.2016.4491.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeArterial spin labeling magnetic resonance imagingCollateral blood vesselsNeurologic outcomeMRS scoreMagnetic resonance imagingNeurological outcomeIschemic strokeScale scoreHealth Stroke Scale scoreResonance imagingMultivariable ordinal logistic regression modelsTertiary academic medical centerBlood vesselsAdmission National InstitutesPremorbid mRS scoreGood neurologic outcomeGood neurological outcomeRetrospective cohort studyStroke Scale scoreRankin Scale scorePresence of collateralsAcademic medical centerLogistic regression modelsOrdinal logistic regression models
2016
Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Wang H, Wold J, Chung L, Tirschwell DL, Majersik JJ. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research And Treatment 2016, 2016: 7670161. PMID: 27974991, PMCID: PMC5126417, DOI: 10.1155/2016/7670161.Peer-Reviewed Original ResearchBlood pressure variabilityLower mean blood pressureSystolic blood pressure variabilityMean blood pressureWorse neurologic outcomeBlood pressureIschemic strokeNeurologic outcomeVessel occlusionPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeAcute ischemic stroke patientsDiastolic blood pressure variabilityProximal vessel occlusionAcute ischemic strokeAnterior circulation strokeIschemic stroke patientsLogistic regression modelsOrdinal logistic regression modelsRankin ScaleAcute settingThrombolytic therapyStroke patientsPatient population