2024
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentationDiffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients
Sorby‐Adams A, Guo J, de Havenon A, Payabvash S, Sze G, Pinter N, Jaikumar V, Siddiqui A, Baldassano S, Garcia‐Guarniz A, Zabinska J, Lalwani D, Peasley E, Goldstein J, Nelson O, Schaefer P, Wira C, Pitts J, Lee V, Muir K, Nimjee S, Kirsch J, Iglesias J, Rosen M, Sheth K, Kimberly W. Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients. Annals Of Neurology 2024, 96: 321-331. PMID: 38738750, PMCID: PMC11293843, DOI: 10.1002/ana.26954.Peer-Reviewed Original ResearchStroke patientsAcute ischemic strokeCut-pointsIschemic strokeStroke patients <Diagnosis of acute ischemic strokeSignal intensity ratioFluid-attenuated inversion recoveryAcute stroke patientsOptimal cut-pointMagnetic resonance imagingDiffusion-weighted imagingDWI-FLAIR mismatchStroke onsetTrained assessorsNational InstituteStrokeThrombolytic interventionNegative predictive valueFLAIR hyperintensitiesPatientsInterobserver agreementHyperacute strokeDiffusion-weightedPredictive value
2023
Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingIntracerebral hemorrhageClinical informationYale-New Haven HospitalLow‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Sujijantarat N, Koo A, Jambor I, Malhotra A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Lalwani D, Zabinska J, Roy J, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Gilmore E, Sansing L, de Havenon A, Olexa M, Schiff S, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.000921.Peer-Reviewed Original ResearchMechanical thrombectomyInterventional radiology suiteMagnetic resonance imagingRadiology suiteConventional MRIResonance imagingCerebral Infarction scoreOngoing brain injuryLarge vessel occlusionInfarct burdenRevascularization timeInfarct volumeClinical characteristicsInfarct progressionAdverse eventsIschemic changesMethods PatientsMedian timeBedside evaluationBrain injuryTimely imagingResults TwentyPatientsSubsequent imagingProcedural detailsAcute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilationImprovement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity
de Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesIncident strokePrimary outcomeHypertensive individualsMatter hyperintensitiesAtherosclerotic cardiovascular disease risk scoreCognitive impairmentCardiovascular disease risk scoreVascular risk factorsCurrent cigarette smokingDisease risk scoreMagnetic resonance imagingLogistic regression modelsRandomization armCerebrovascular eventsVascular riskCigarette smokingPrognostic informationRisk factorsPrognostic abilityRisk scoreCognitive declineResonance imagingDeLong testStrokeIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation index
2022
CGRP, Migraine, and Brain MRI in CADASIL
Goldstein E, Gopal N, Badi M, Hodge D, de Havenon A, Glover P, Durham P, Huang J, Lin M, Baradaran H, Majersik J, Meschia J. CGRP, Migraine, and Brain MRI in CADASIL. The Neurologist 2022, 28: 231-236. PMID: 36729391, PMCID: PMC10277309, DOI: 10.1097/nrl.0000000000000478.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideMigraine-related disabilitySerum calcitonin gene-related peptideSerum CGRP levelsCGRP levelsBrain magnetic resonance imagingCerebral autosomal dominant arteriopathyGene-related peptideAutosomal dominant arteriopathyMagnetic resonance imagingCross-sectional analysisRadiographic associationRadiographic implicationsPrimary outcomeT2 hyperintensityCerebral microbleedsDisability ScaleSubcortical infarctsMigraine pathophysiologyVasoactive peptidesBrain MRIMigraine pathologyMigraineResonance imagingCADASILMechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee
Nguyen T, Castonguay A, Siegler J, Nagel S, Lansberg M, de Havenon A, Sheth S, Abdalkader M, Tsai J, Albers G, Masoud H, Jovin T, Martins S, Nogueira R, Zaidat O, Committee F. Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee. Stroke Vascular And Interventional Neurology 2022, 3 PMID: 39380893, PMCID: PMC11460660, DOI: 10.1161/svin.122.000512.Peer-Reviewed Original ResearchSociety of VascularLarge vessel occlusion strokeLarge vessel occlusionNeurology guidelinesExtended time windowOcclusion strokeEndovascular therapyVessel occlusionAnterior circulation large vessel occlusion strokeClinical-imaging mismatchDEFUSE 3 studyComputed tomography perfusionRecent clinical trialsTreatment of patientsNew treatment paradigmSole imaging modalityMagnetic resonance imagingWriting groupMechanical thrombectomyEndovascular treatmentPatient selectionInfarct sizeLate presentationTomography perfusionTreatment paradigm
2021
MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy
Muddasani V, de Havenon A, McNally JS, Baradaran H, Alexander MD. MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy. Topics In Magnetic Resonance Imaging 2021, 30: 197-204. PMID: 34397969, PMCID: PMC8371677, DOI: 10.1097/rmr.0000000000000277.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingIschemic strokeComputed tomographyMR perfusionCore infarctDiffusion-weighted magnetic resonance imagingPerfusion-diffusion mismatchDegree of ischemiaNoncontrast Computed TomographyImproved imaging techniquesSalvageable brainSuperior diagnostic informationIschemic penumbraSymptom onsetAcute evaluationAppropriate imagingPatient selectionStroke therapyThrombolytic therapyPoor outcomePrognostic valueLeading causeEffective treatmentBetter outcomesEarly identificationThe association between transthoracic echocardiogram parameters and white matter hyperintensities
Navarro KS, Wong KH, Ibrahim MM, de Havenon AH, Goldstein ED. The association between transthoracic echocardiogram parameters and white matter hyperintensities. Clinical Neurology And Neurosurgery 2021, 206: 106672. PMID: 33979694, DOI: 10.1016/j.clineuro.2021.106672.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBrain magnetic resonance imagingCerebral small vessel diseaseVentricular ejection fractionCardiac chamber sizeTransthoracic echocardiogramFazekas scoreEjection fractionAtrial areaTricuspid annular plane systolic excursionAnnular plane systolic excursionRight ventricular ejection fractionRight ventricular internal diameterRetrospective chart reviewRight atrial areaSmall vessel diseaseVentricular internal diameterMultivariate ordinal logistic regression modelWhite matter hyperintensitiesChamber sizeLogistic regression modelsOrdinal logistic regression modelsMore WMHChart reviewSystolic excursion
2019
Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis
Alexander MD, de Havenon A, Kim SE, Parker DL, McNally JS. Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis. Neuroradiology 2019, 61: 643-650. PMID: 30675639, PMCID: PMC8022353, DOI: 10.1007/s00234-019-02167-3.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseVessel wall magnetic resonance imagingInter-rater agreementLower infundibulumHigh inter-rater agreementVessel wall magnetic resonanceGood inter-rater agreementPost-contrast imagingPresence of enhancementMagnetic resonance imagingPost-contrast imagesRatio of enhancementCulprit lesionIntracranial atherosclerosisAtherosclerotic diseaseInclusion criteriaBlinded reviewersResonance imagingLesion enhancementHigh agreementPlaque signalLesionsInfundibulumObjective dataMagnetic resonance
2018
Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection
McNally JS, Hinckley PJ, Sakata A, Eisenmenger LB, Kim SE, De Havenon AH, Quigley EP, Iacob E, Treiman GS, Parker DL. Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection. Stroke 2018, 49: 2337-2344. PMID: 30355108, PMCID: PMC6208137, DOI: 10.1161/strokeaha.118.021868.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeCervical artery dissectionIntramural hematomaIschemic strokeArtery dissectionT1-weighted sequencesIMH detectionMagnetic resonance imaging/magnetic resonance angiographyGradient-recalled echoMethods Institutional review board approvalIschemic stroke pathogenesisCardiovascular risk factorsStroke sourcesInterrater reliabilityMultivariate Poisson regressionReview board approvalMagnetic resonance angiographyMagnetic resonance imagingStroke prediction modelsStroke pathogenesisAcute strokeCurrent smokingClinical factorsAtherosclerotic diseaseImaging findings
2017
High-resolution magnetic resonance imaging of intracranial aneurysms treated by flow diversion
Guan J, Karsy M, McNally S, de Havenon A, Kalani M, Taussky P, Kim S, Park M. High-resolution magnetic resonance imaging of intracranial aneurysms treated by flow diversion. Interdisciplinary Neurosurgery 2017, 10: 69-74. DOI: 10.1016/j.inat.2017.07.004.Peer-Reviewed Original ResearchHigh-resolution magnetic resonance imagingMagnetic resonance imagingAneurysm treatmentAneurysm obliterationFlow diversionResonance imagingAneurysm sac thrombosisVertebral artery pseudoaneurysmPosterior communicating aneurysmDigital subtraction angiographySac thrombosisArtery pseudoaneurysmIschemic strokeOphthalmic segmentCase seriesEndovascular treatmentIntracerebral aneurysmsPatient 2Patient 3Subarachnoid hemorrhageMetastatic melanomaClose imagingTreatment responseAneurysm sacDiverter treatmentAdded Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies
Mossa-Basha M, Shibata DK, Hallam DK, de Havenon A, Hippe DS, Becker KJ, Tirschwell DL, Hatsukami T, Balu N, Yuan C. Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies. Stroke 2017, 48: 3026-3033. PMID: 29030476, PMCID: PMC5687293, DOI: 10.1161/strokeaha.117.018227.Peer-Reviewed Original ResearchConceptsIntracranial vessel wall magnetic resonance imagingVessel wall magnetic resonance imagingLuminal imagingIntracranial vasculopathyMagnetic resonance imagingInflammatory vasculopathyWall involvementResonance imagingReversible cerebral vasoconstriction syndromeCerebral vasoconstriction syndromeIntracranial atherosclerotic diseasePattern of involvementAtherosclerotic diseaseLesion eccentricityPostcontrast enhancementClinical dataSyndrome patientsVasculopathyPatient basisPatient analysisDiagnostic agreementSlight agreementDiagnosisDiagnostic confidenceLesionsAssociation of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke
de Havenon A, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB. Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurology 2017, 74: 453-458. PMID: 28192548, PMCID: PMC5470363, DOI: 10.1001/jamaneurol.2016.4491.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeArterial spin labeling magnetic resonance imagingCollateral blood vesselsNeurologic outcomeMRS scoreMagnetic resonance imagingNeurological outcomeIschemic strokeScale scoreHealth Stroke Scale scoreResonance imagingMultivariable ordinal logistic regression modelsTertiary academic medical centerBlood vesselsAdmission National InstitutesPremorbid mRS scoreGood neurologic outcomeGood neurological outcomeRetrospective cohort studyStroke Scale scoreRankin Scale scorePresence of collateralsAcademic medical centerLogistic regression modelsOrdinal logistic regression models
2016
E-073 High Resolution Magnetic Resonance Imaging of Intracranial Aneurysms Treated by Flow Diversion
Guan J, McNally S, de Havenon A, Tuassky P, Kim S, Park M. E-073 High Resolution Magnetic Resonance Imaging of Intracranial Aneurysms Treated by Flow Diversion. Journal Of NeuroInterventional Surgery 2016, 8: a80. DOI: 10.1136/neurintsurg-2016-012589.145.Peer-Reviewed Original ResearchHigh-resolution MRIIntracranial aneurysmsFlow diversionHigh-resolution magnetic resonance imagingResolution MRIResolution magnetic resonance imagingMagnetic resonance imagingEndovascular aneurysm treatmentPre-contrast imagesIntracerebral aneurysmsPatient populationAneurysm treatmentResonance imagingAneurysmsFlow diverterSurveillance toolLower ratesMRIDiversionFollowupMorbidityRecurrenceDiverterMortalityPathologyAdded Value of Vessel Wall Magnetic Resonance Imaging in the Differentiation of Moyamoya Vasculopathies in a Non-Asian Cohort
Mossa-Basha M, de Havenon A, Becker KJ, Hallam DK, Levitt MR, Cohen WA, Hippe DS, Alexander MD, Tirschwell DL, Hatsukami T, Amlie-Lefond C, Yuan C. Added Value of Vessel Wall Magnetic Resonance Imaging in the Differentiation of Moyamoya Vasculopathies in a Non-Asian Cohort. Stroke 2016, 47: 1782-1788. PMID: 27272486, PMCID: PMC4927346, DOI: 10.1161/strokeaha.116.013320.Peer-Reviewed Original ResearchConceptsVessel wall magnetic resonance imagingMagnetic resonance imagingMoyamoya diseaseLuminal imagingInter-reader agreementMoyamoya vasculopathyResonance imagingCarotid artery territoryNon-Asian cohortsMoyamoya disease casesPattern of involvementT2 signal characteristicsArtery territoryCarotid diseaseCollateral gradingConcentric lesionsCollateral extentPostcontrast enhancementMRI characteristicsHeterogeneous enhancementMulticontrast protocolClinical dataCarotid segmentsHeterogeneous lesionsT2 heterogeneity
2015
Nonstenotic Culprit Plaque: The Utility of High‐Resolution Vessel Wall MRI of Intracranial Vessels after Ischemic Stroke
de Havenon A, Yuan C, Tirschwell D, Hatsukami T, Anzai Y, Becker K, Sultan-Qurraie A, Mossa-Basha M. Nonstenotic Culprit Plaque: The Utility of High‐Resolution Vessel Wall MRI of Intracranial Vessels after Ischemic Stroke. Case Reports In Radiology 2015, 2015: 356582. PMID: 26346855, PMCID: PMC4543789, DOI: 10.1155/2015/356582.Peer-Reviewed Original ResearchIntracranial atherosclerotic diseaseIschemic strokeThromboembolic eventsClinical eventsHigh-resolution vessel wall MRIMultiple high-risk featuresPatient's clinical eventsPatients thromboembolic eventsHigh-risk featuresHigh-resolution magnetic resonance imagingMagnetic resonance imagingArterial vessel wallVessel wall MRINonstenotic plaquesAntiplatelet therapyCryptogenic strokeStroke workupThromboembolic strokeMedical managementAtherosclerotic diseaseHR-MRIIntracranial vesselsResonance imagingStrokeImaging modalitiesMulticontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes
Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, Tirschwell DT, Hatsukami T, Anzai Y, Yuan C. Multicontrast High-Resolution Vessel Wall Magnetic Resonance Imaging and Its Value in Differentiating Intracranial Vasculopathic Processes. Stroke 2015, 46: 1567-1573. PMID: 25953365, DOI: 10.1161/strokeaha.115.009037.Peer-Reviewed Original ResearchConceptsReversible cerebral vasoconstriction syndromeVessel wall magnetic resonance imagingCerebral vasoconstriction syndromeMagnetic resonance imagingT2 hyperintensityIntracranial vasculopathyResonance imagingWall thickeningPattern of enhancementCases of atherosclerosisIntracranial vascular diseaseT2 signal characteristicsExcellent inter-reader agreementInter-reader agreementVasculitic lesionsInvasive workupWall involvementStenotic lesionsVasculopathic processPostcontrast enhancementVascular diseaseDifferential diagnosisVasculopathyLesion typeSyndrome