2024
Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies
Sharma R, de Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies. BMJ Neurology Open 2024, 6: e000501. PMID: 38288313, PMCID: PMC10823923, DOI: 10.1136/bmjno-2023-000501.Peer-Reviewed Original ResearchVascular brain injurySlow walkingAtherosclerosis RiskMobility impairmentsAssociated with mobility impairmentImpaired mobilityUK Biobank (UKBStroke-free cohortMarkers of vascular brain injuryAdjusted multivariate logistic regression analysisGait dataMultivariate logistic regression analysisCommunity-dwellingLogistic regression analysisBrain injuryARICUKBInclusion criteriaStudy cohortWalkingClinical strokeRegression analysisImpaired outcomeMRI markersStudy background
2022
Borderzone infarction and recurrent stroke in intracranial atherosclerosis
Kvernland A, Torres J, Raz E, Nossek E, de Havenon A, Gebregziabher M, Khatri P, Prabhakaran S, Liebeskind D, Yaghi S. Borderzone infarction and recurrent stroke in intracranial atherosclerosis. Journal Of Stroke And Cerebrovascular Diseases 2022, 32: 106897. PMID: 36402094, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106897.Peer-Reviewed Original ResearchConceptsRecurrent cerebrovascular eventsIntracranial stenosisBorderzone infarctsInfarct patternsIschemic strokeBorderzone infarctionRetrospective single-center studyAcute ischemic strokeRecurrent ischemic strokeSingle-center studySymptomatic intracranial stenosisHigh-risk cohortBinary logistic regression analysisDistal blood flowAlternative treatment strategiesLogistic regression analysisLogistic regression modelsCerebrovascular eventsRecurrent strokeIntracranial atherosclerosisPrimary outcomeCenter studyMean ageSurrogate markerTreatment strategiesPost-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study
Frontera JA, Thorpe LE, Simon NM, de Havenon A, Yaghi S, Sabadia SB, Yang D, Lewis A, Melmed K, Balcer LJ, Wisniewski T, Galetta SL. Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study. PLOS ONE 2022, 17: e0275274. PMID: 36174032, PMCID: PMC9521913, DOI: 10.1371/journal.pone.0275274.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeDifferent therapeutic interventionsTherapeutic interventionsTherapeutic strategiesAcute SARS-CoV-2 infectionOccupational therapySARS-CoV-2 infectionOutcome metricsSimilar therapeutic interventionsProspective cohort studyShortness of breathAnti-anxiety medicationsLogistic regression analysisCOVID-19Individual treatment programsPASC symptomsCohort studySymptom improvementUnsupervised hierarchical cluster analysisTreatment strategiesObservational studySleep disordersVariable symptomatologySymptom groupsCognitive symptoms
2021
EP31* Vessel wall MRI findings improve specificity for detection of delayed in-stent stenosis following flow diversion of unruptured aneurysms
Alexander M, Costello J, McNally J, de Havenon A, Grandhi R. EP31* Vessel wall MRI findings improve specificity for detection of delayed in-stent stenosis following flow diversion of unruptured aneurysms. Journal Of NeuroInterventional Surgery 2021, 13: a13-a13. DOI: 10.1136/neurintsurg-2021-esmint.31.Peer-Reviewed Original ResearchSubsequent digital subtraction angiographyDigital subtraction angiographyVessel wall MRIStent stenosisUnruptured aneurysmsExact testExact logistic regression analysisIntracranial vascular pathologyLogistic regression analysisFisher's exact testUnruptured intracranial aneurysmsFlow diverter treatmentFlow diverter implantationBlack-blood sequenceMRI findingsMultivariable analysisCommon findingStudy groupVascular pathologyStenosisBlood sequenceCerebral aneurysmsDiverter treatmentAneurysmsIntracranial aneurysms
2019
Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis
Yaghi S, Khatri P, de Havenon A, Yeatts S, Chang AD, Cutting S, Grory B, Burton T, Jayaraman MV, McTaggart RA, Fiorella D, Derdeyn C, Zaidat OO, Dehkharghani S, Amin-Hanjani S, Furie K, Prahbakaran S, Liebeskind D. Peri-procedural stroke or death in stenting of symptomatic severe intracranial stenosis. Journal Of NeuroInterventional Surgery 2019, 12: 374. PMID: 31484697, PMCID: PMC8022354, DOI: 10.1136/neurintsurg-2019-015225.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial atherosclerosisAngioplasty/stentingPrimary outcomeSAMMPRIS trialLesion lengthPeri-procedural strokeSevere intracranial stenosisStroke/deathOdds of strokeNew clinical trialsProcedure-specific variablesLogistic regression analysisPatient-specific variablesModest predictive valueSymptomatic severe intracranial stenosisIntracranial atherosclerosisSmoking historySmoking statusIntracranial stenosisFDA indicationClinical trialsPatientsReliable biomarkersStentingPredictive value
2018
Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome
Bennett AE, Wilder MJ, McNally JS, Wold JJ, Stoddard GJ, Majersik JJ, Ansari S, de Havenon A. Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome. Journal Of NeuroInterventional Surgery 2018, 10: 823. PMID: 29352059, DOI: 10.1136/neurintsurg-2017-013473.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleBlood pressure variabilityIntra-arterial therapyIntravenous tissue plasminogen activatorPressure variabilityTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsIschemic strokeWorse outcomesMean age 63.2 yearsMedian admission National InstitutesMultivariable ordinal logistic regression modelsSystolic blood pressure variabilityPlasminogen activatorAdmission National InstitutesWorse neurologic outcomeWorse clinical outcomesLogistic regression analysisOrdinal logistic regression analysisIndependent predictive abilitySuccessive variationAcute strokeEndovascular thrombectomyNeurologic outcome