2023
Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity
de Havenon A, Abbasi M, Yaghi S, Delic A, Bangad A, Johnston K, Tirschwell D, Sheth K. Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity. Annals Of Neurology 2023, 93: 1106-1116. PMID: 36852919, DOI: 10.1002/ana.26621.Peer-Reviewed Original ResearchConceptsIV-tPAHigher NIHSSIschemic strokeAtrial fibrillationNational Inpatient Sample (NIS) 2016Non-Hispanic white raceOlder ageBaseline National InstitutesDEFUSE-3 trialsHealth Stroke ScalePost-stroke mortalityIschemic stroke mortalityEffect of alteplaseRisk of mortalityLogistic regression modelsAnn NeurolFAST-MAGIMS IIISevere ISHospital mortalityIntravenous alteplaseSevere strokeStroke ScaleStroke severityFunctional outcome
2022
Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score
Klein P, Shu L, Nguyen TN, Siegler JE, Omran SS, Simpkins AN, Heldner M, de Havenon A, Aparicio HJ, Abdalkader M, Psychogios M, Vedovati MC, Paciaroni M, von Martial R, Liebeskind DS, de Sousa D, Coutinho JM, Yaghi S, Group F. Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score. Journal Of Stroke 2022, 24: 404-416. PMID: 36221944, PMCID: PMC9561213, DOI: 10.5853/jos.2022.01606.Peer-Reviewed Original ResearchCerebral venous thrombosisPoor neurological outcomePoor outcomeNeurological outcomeVenous thrombosisPrognostic scoreRisk factorsInternational multicenter retrospective studyMulticenter retrospective studyMultivariable logistic regressionFuture clinical trialsActive cancerHigher NIHSSConsecutive patientsMedian ageMultivariable analysisRetrospective studyMRS 3Black raceRadiographic characteristicsClinical trialsPrognostic accuracyHigh riskPatientsClinical decision