2024
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentation
2023
Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes
de Havenon A, Zaidat O, Amin-Hanjani S, Nguyen T, Bangad A, Abbasi M, Anadani M, Almallouhi E, Chatterjee R, Mazighi M, Mistry E, Yaghi S, Derdeyn C, Hong K, Kvernland A, Leslie-Mazwi T, Al Kasab S. Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes. Stroke 2023, 54: 1695-1705. PMID: 36938708, PMCID: PMC10202848, DOI: 10.1161/strokeaha.122.040008.Peer-Reviewed Original ResearchConceptsLarge vessel occlusion strokeIntracranial atherosclerotic diseaseEndovascular thrombectomyAtherosclerotic diseaseOcclusion strokeFunctional outcome benefitsVascular risk factorsAdjunctive medicationsMedical managementPatient factorsInterventional treatmentOutcome benefitsRisk factorsObservational studyEarly identificationTreatment planningThrombectomyUnique considerationsPatientsStrokeLVODiseaseRevascularizationMedicationsReview
2022
Cholesterol-Lowering Medication Use Prior to Ischemic Strokes Secondary to Large Artery Atherosclerosis or Small Vessel Disease: A Single Center Study (S35.009)
Garg A, Baker A, Faridi K, De Havenon A, Sheth K, Forman R, Sharma R. Cholesterol-Lowering Medication Use Prior to Ischemic Strokes Secondary to Large Artery Atherosclerosis or Small Vessel Disease: A Single Center Study (S35.009). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3531.Peer-Reviewed Original Research
2021
Lacunar stroke: mechanisms and therapeutic implications
Yaghi S, Raz E, Yang D, Cutting S, Mac Grory B, Elkind MS, de Havenon A. Lacunar stroke: mechanisms and therapeutic implications. Journal Of Neurology Neurosurgery & Psychiatry 2021, 92: 823-830. PMID: 34039632, DOI: 10.1136/jnnp-2021-326308.Peer-Reviewed Original ResearchLacunar strokeNeurological deteriorationTreatment strategiesTherapeutic implicationsCerebral small vessel diseaseLacunar stroke patientsStroke prevention strategiesAntithrombotic treatment strategiesLong-term disabilitySmall vessel diseaseNovel treatment strategiesAtheromatous diseaseIschemic strokeStroke patientsVessel diseaseNeurovascular imagingStroke mechanismHeterogeneous diseaseSystemic evaluationPrevention strategiesNarrative reviewStrokePatientsDiseaseUnderlying mechanismEndothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease
Liebeskind DS, Hinman JD, Kaneko N, Kitajima H, Honda T, De Havenon AH, Feldmann E, Nogueira RG, Prabhakaran S, Romano JG, Callas PW, Schneider DJ. Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease. Frontiers In Neurology 2021, 12: 646309. PMID: 33716947, PMCID: PMC7947292, DOI: 10.3389/fneur.2021.646309.Peer-Reviewed Original ResearchIntracranial atherosclerotic diseaseEndothelial shear stressFcγRIIa expressionAtherosclerotic diseaseFcγRIIA receptorsArterial stenosisAnti-platelet medicationAnti-platelet strategiesPotent risk factorLocal pathophysiologyRecurrent strokeRisk factorsCardiovascular diseaseVascular remodelingIndividual patientsPlaque growthPlatelet activationElevated expressionDiseasePlatelet interactionClinical realmRecurrent eventsStenosisDifferential activationLuminal wall
2020
Introduction to Management of Carotid Disease
Ishaque M, de Havenon A, McNally J, Kalani M, Park M. Introduction to Management of Carotid Disease. 2020, 1-5. DOI: 10.1007/978-3-030-41138-1_1.Peer-Reviewed Original Research
2019
Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies
de Havenon A, Muhina HJ, Parker DL, McNally JS, Alexander MD. Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies. American Journal Of Neuroradiology 2019, 40: 1709-1711. PMID: 31515211, PMCID: PMC6785399, DOI: 10.3174/ajnr.a6191.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseAtherosclerotic diseaseContrast administrationMR imaging studiesVessel wall MR imagingSignal intensity changesPlaque enhancementGadolinium administrationVessel wall MRImaging studiesMR imagingLonger durationAdministrationGreater increaseDiseaseDurationCohortTime Elapsed
2017
High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease
de Havenon A, Mossa-Basha M, Shah L, Kim SE, Park M, Parker D, McNally JS. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease. Neuroradiology 2017, 59: 1193-1202. PMID: 28942481, DOI: 10.1007/s00234-017-1925-9.Peer-Reviewed Original ResearchConceptsHigh-resolution vessel wall MRIVessel wall MRIIntracranial atherosclerosisPrognosis of patientsIntracranial atherosclerotic diseasePost-contrast enhancementDiagnostic imaging techniquesHigh field strength MRIIschemic strokeStroke etiologyAtherosclerotic diseaseCerebrovascular diseaseVessel wall morphologyVascular pathologyIntracranial arteriesEnhancement patternRecurrence riskAtherosclerosisTranslational perspectiveVessel wallClinical interpretationMRIStrength MRIDisease
2011
A perforated diverticulum in Cushing's disease
de Havenon A, Ehrenkranz J. A perforated diverticulum in Cushing's disease. International Journal Of Surgery Case Reports 2011, 2: 215-217. PMID: 22096731, PMCID: PMC3199613, DOI: 10.1016/j.ijscr.2011.06.009.Peer-Reviewed Original Research