2019
Subclinical Cerebrovascular Disease: Epidemiology and Treatment
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L. Subclinical Cerebrovascular Disease: Epidemiology and Treatment. Current Atherosclerosis Reports 2019, 21: 39. PMID: 31350593, PMCID: PMC8011954, DOI: 10.1007/s11883-019-0799-1.Peer-Reviewed Original ResearchConceptsMedical managementRisk factorsAggressive medical managementSilent brain infarctsOptimal medical treatmentVascular risk factorsDevelopment of dementiaBest medical managementImportant risk factorLate-life depressionCommon clinical scenariosWhite matter hyperintensitiesT2-weighted MRISusceptibility-weighted MRIEvidence-based approachBrain infarctsCerebral microbleedsCerebrovascular diseaseGait instabilityBrain healthClinical equipoiseWorse outcomesClinical trialsMatter hyperintensitiesEpidemiologic studiesCarotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study
de Havenon A, Wong K, Elkhetali A, McNally JS, Majersik JJ, Rost NS. Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study. American Journal Of Neuroradiology 2019, 40: 1369-1373. PMID: 31248859, PMCID: PMC7048485, DOI: 10.3174/ajnr.a6115.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensity volumeCarotid artery stiffnessTotal brain volumePressure-strain elastic modulusArtery stiffnessHyperintensity volumeBrain volumeAtherosclerosis RiskArterial stiffnessMR imagingCommunity studyStiffness indexHigher white matter hyperintensity volumeLower total brain volumeSecondary analysisCommon carotid artery stiffnessSmall artery diseaseMultivariable linear regression modelsCerebrovascular diseaseDementia riskSonography measurementsMultivariate modelCarotid strainPotential mechanismsPatients
2017
High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease
de Havenon A, Mossa-Basha M, Shah L, Kim SE, Park M, Parker D, McNally JS. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease. Neuroradiology 2017, 59: 1193-1202. PMID: 28942481, DOI: 10.1007/s00234-017-1925-9.Peer-Reviewed Original ResearchConceptsHigh-resolution vessel wall MRIVessel wall MRIIntracranial atherosclerosisPrognosis of patientsIntracranial atherosclerotic diseasePost-contrast enhancementDiagnostic imaging techniquesHigh field strength MRIIschemic strokeStroke etiologyAtherosclerotic diseaseCerebrovascular diseaseVessel wall morphologyVascular pathologyIntracranial arteriesEnhancement patternRecurrence riskAtherosclerosisTranslational perspectiveVessel wallClinical interpretationMRIStrength MRIDisease