Featured Publications
Predictors of new persistent opioid use after benign hysterectomy in the United States
AlAshqar A, Ishiwata R, Moss C, Andersen KM, Yanek L, Bicket MC, Alexander GC, Borahay MA. Predictors of new persistent opioid use after benign hysterectomy in the United States. American Journal Of Obstetrics And Gynecology 2022, 227: 68.e1-68.e24. PMID: 35248573, PMCID: PMC9253094, DOI: 10.1016/j.ajog.2022.02.030.Peer-Reviewed Original ResearchConceptsNew persistent opioid usePersistent opioid usePerioperative opioid prescriptionOpioid usePerioperative prescriptionBenign hysterectomyOpioid prescriptionsSurgical complicationsClinical Classification Software codesNational insurance claims databaseLogistic regressionNew persistent usePrevalent opioid useRetrospective cohort studyInsurance Claims DatabaseMultivariate logistic regressionPersistent usePreoperative painCohort studyNaïve womenInvasive hysterectomyMedication usePain disordersSurgical indicationsTobacco smoking
2024
Dispensing patterns of antidepressant and antianxiety medications for psychiatric disorders after benign hysterectomy in reproductive-age women: Results from group-based trajectory modeling
Ishiwata R, AlAshqar A, Miyashita-Ishiwata M, Borahay M. Dispensing patterns of antidepressant and antianxiety medications for psychiatric disorders after benign hysterectomy in reproductive-age women: Results from group-based trajectory modeling. Women's Health 2024, 20: 17455057241272218. PMID: 39165003, PMCID: PMC11339748, DOI: 10.1177/17455057241272218.Peer-Reviewed Original ResearchConceptsGroup-based-trajectory modellingBenign hysterectomyReproductive-age womenUterine fibroidsAA medicationsTime of hysterectomyPatterns of antidepressantsPsychiatric disordersDispensing patternsCo-existing psychiatric diagnosisStudy periodStudy of womenClusters of patientsPelvic painAbnormal bleedingDiscontinuation ratesClinical predictorsHysterectomyGynecological symptomsGynecological disordersTrajectory groupsPerioperative periodAntidepressantsInclusion criteriaAnxiety disorders
2023
Association of Surgical Start Time with Outcomes of Benign Hysterectomy
Brah T, AlAshqar A, Borahay M. Association of Surgical Start Time with Outcomes of Benign Hysterectomy. Journal Of Minimally Invasive Gynecology 2023, 30: 389-396. PMID: 36708764, DOI: 10.1016/j.jmig.2023.01.008.Peer-Reviewed Original ResearchConceptsSurgical start timeSame-day dischargeLength of stayAdverse perioperative eventsBlood lossBenign hysterectomyPerioperative eventsPerioperative adverse eventsRetrospective cohort studyTotal hospital chargesOperating room timeLaparoscopic cohortPerioperative outcomesAdverse eventsCohort studyBenign indicationsHospital chargesSurgical approachHysterectomyRoom timeMultivariate linear regressionStayHealthcare systemDecreased rateLinear regression
2022
Perioperative opioid dispensing and persistent use after benign hysterectomy: a systematic review and meta-analysis
Hessami K, Welch J, Frost A, AlAshqar A, Arian S, Gough E, Borahay M. Perioperative opioid dispensing and persistent use after benign hysterectomy: a systematic review and meta-analysis. American Journal Of Obstetrics And Gynecology 2022, 229: 23-32.e3. PMID: 36539027, PMCID: PMC10276170, DOI: 10.1016/j.ajog.2022.12.015.Peer-Reviewed Original ResearchConceptsPersistent opioid useOpioid useBenign hysterectomyHysterectomy routeOpioid dispensingsAbdominal hysterectomyVaginal hysterectomyBack painAlcohol useDosage of opioidsEquivalents of opioidsRoute of hysterectomyYounger patient ageRandom-effects modelWeb of SciencePerioperative opioidsPatient agePerioperative periodSecondary outcomesPrimary outcomeHysterectomyOpioidsHigh riskOperative complexityStudy inceptionImpact of Obesity on Clinical and Financial Outcomes of Minimally Invasive Hysterectomy for Benign Conditions
Le Neveu M, AlAshqar A, Kohn J, Tambovtseva A, Wang K, Borahay M. Impact of Obesity on Clinical and Financial Outcomes of Minimally Invasive Hysterectomy for Benign Conditions. Journal Of Obstetrics And Gynaecology Canada 2022, 44: 953-959. PMID: 35598864, PMCID: PMC9481667, DOI: 10.1016/j.jogc.2022.04.018.Peer-Reviewed Original ResearchConceptsLength of stayClass III obesityAdverse perioperative eventsEffect of obesityInvasive hysterectomyPerioperative eventsClass IRetrospective cohort studyImpact of obesityOperating room timeCohort studyMean BMIBlood lossBenign hysterectomyClinical outcomesHysterectomy methodsHospital chargesRobotic hysterectomyObesityHysterectomyRoom timePatientsBenign conditionsClass IIIClass IICardiometabolic profile of women with uterine leiomyoma: a cross-sectional study.
Alashqar A, El Ouweini H, Gornet M, Yenokyan G, Borahay MA. Cardiometabolic profile of women with uterine leiomyoma: a cross-sectional study. Minerva Obstetrics And Gynecology 2022, 75: 27-38. PMID: 35333033, DOI: 10.23736/s2724-606x.22.04952-1.Peer-Reviewed Original ResearchConceptsCardiometabolic risk factorsCardiometabolic comorbiditiesCross-sectional studyUterine leiomyomaCardiometabolic profileMedication useRisk factorsJohns Hopkins Health SystemEpic electronic medical record systemUnfavorable cardiometabolic profileCardiovascular disease preventionPrevalence odds ratiosUterine leiomyoma developmentElectronic medical record systemAssociated medicationsLeiomyoma riskMedical record systemOnly medicationEssential hypertensionMetabolic syndromeHospital encountersPrescription medicationsEarly managementOdds ratioLeiomyoma diagnosis
2021
Predictors of same‐day discharge after minimally invasive hysterectomy for benign indications
AlAshqar A, Wildey B, Yazdy G, Goktepe ME, Kilic GS, Borahay MA. Predictors of same‐day discharge after minimally invasive hysterectomy for benign indications. International Journal Of Gynecology & Obstetrics 2021, 158: 308-317. PMID: 34674257, DOI: 10.1002/ijgo.13992.Peer-Reviewed Original ResearchConceptsSame-day dischargeInvasive hysterectomySurgeon factorsPostoperative day 0Retrospective cohort studyShorter operative timeMinimal blood lossMultivariate logistic regressionSame dayProcedure start timePostoperative complicationsCohort studyBlood lossEarly dischargeBenign indicationsOperative timeRobotic hysterectomySurgeon numberStudy populationHysterectomyLarge cohortDay 0Logistic regressionPatientsSurgeon educationVascular biology of uterine fibroids: connecting fibroids and vascular disorders.
Kirschen GW, AlAshqar A, Miyashita-Ishiwata M, Reschke L, El Sabeh M, Borahay MA. Vascular biology of uterine fibroids: connecting fibroids and vascular disorders. Reproduction 2021, 162: r1-r18. PMID: 34034234, PMCID: PMC8320308, DOI: 10.1530/rep-21-0087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVascular disordersMyometrial smooth muscle cellsSystemic vascular disorderSmooth muscle cellsAbdominal painAldosterone systemUrinary retentionEndothelial dysfunctionEssential hypertensionUterine fibroidsBenign tumorsFibroid growthDisease processFibroidsNovel treatmentsFibroid pathogenesisMuscle cellsCell-intrinsic factorsVascular biologyPharmaceutical agentsUterusVasculature systemDisordersConstipationHypertensionDiet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies
Afrin S, AlAshqar A, Sabeh M, Miyashita-Ishiwata M, Reschke L, Brennan JT, Fader A, Borahay MA. Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies. Nutrients 2021, 13: 1747. PMID: 34063835, PMCID: PMC8224039, DOI: 10.3390/nu13061747.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGynecological disordersDietary habitsPolycystic ovary syndromeCurrent clinical dataPotential confounding factorsPlant-derived natural compoundsOvary syndromeGynecological malignanciesVitamin DGynecological diseasesClinical dataClinical studiesUterine leiomyomaPhysical activityMediterranean dietConfounding factorsEpidemiological investigationsHealthy lifestyleHomeostatic functionsRed meatBalanced dietNutritional factorsNutritional dataDietDisordersRole of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†
AlAshqar A, Reschke L, Kirschen GW, Borahay MA. Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†. Biology Of Reproduction 2021, 105: 7-31. PMID: 33739368, PMCID: PMC8256101, DOI: 10.1093/biolre/ioab054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBenign gynecologic disordersRole of inflammationGynecologic disordersClinical sequelaeCardiometabolic risk factorsNF-κB inhibitorCardiometabolic medicationsInflammatory markersSystemic complicationsGynecologic malignanciesVitamin DInflammatory pathwaysLesion progressionRisk factorsCardiovascular diseaseCyclooxygenase-2Uterine leiomyomaPathophysiological perspectiveSex steroidsHormonal treatmentDiagnostic adjunctTherapeutic implicationsNumerous cytokinesImmune systemInflammation
2020
Predictors of the cost of hysterectomy for benign indications
AlAshqar A, Goktepe ME, Kilic GS, Borahay MA. Predictors of the cost of hysterectomy for benign indications. Journal Of Gynecology Obstetrics And Human Reproduction 2020, 50: 101936. PMID: 33039600, PMCID: PMC7856010, DOI: 10.1016/j.jogoh.2020.101936.Peer-Reviewed Original ResearchConceptsLength of stayCost of hysterectomyRetrospective cohort studyOperating room timeHospital finance departmentElectronic medical recordsConcomitant proceduresBlood lossCohort studyPatient ageBenign indicationsOne-year increaseVaginal approachRobotic hysterectomyHysterectomy costModifiable factorsSurgical approachTexas Medical BranchInsurance typeMedical recordsInvasive approachOpen hysterectomyHysterectomyOperative factorsRoom timeImpact of primary headache disorder on quality of life among school students in Kuwait
Al-Hashel JY, Alroughani R, Shuaibi S, AlAshqar A, AlHamdan F, AlThufairi H, Owayed S, Ahmed SF. Impact of primary headache disorder on quality of life among school students in Kuwait. The Journal Of Headache And Pain 2020, 21: 80. PMID: 32580704, PMCID: PMC7313161, DOI: 10.1186/s10194-020-01124-3.Peer-Reviewed Original ResearchConceptsMiddle school studentsSchool studentsAcademic achievementAcademic yearImpaired Participation (HARDSHIP) questionnaireStudentsHeadache-Attributed RestrictionParticipation QuestionnaireQuestionnaireSchoolsAchievementGenderDisabilityLifeQualityChildrenAdolescentsHandicapImpactCross-sectional studySocial handicapMethodsA cross-sectional studyAssociation of demographic, clinical, and hospital‐related factors with use of robotic hysterectomy for benign indications: A national database study
Smith AJB, AlAshqar A, Chaves KF, Borahay MA. Association of demographic, clinical, and hospital‐related factors with use of robotic hysterectomy for benign indications: A national database study. International Journal Of Medical Robotics And Computer Assisted Surgery 2020, 16: e2107. PMID: 32276286, PMCID: PMC9206512, DOI: 10.1002/rcs.2107.Peer-Reviewed Original ResearchConceptsRobotic hysterectomyPatient factorsBenign indicationsHospital characteristicsGynecologic diagnosisHospital-level disparitiesHospital-related factorsNational database studyNational Inpatient SampleCross-sectional studyBenign hysterectomyInpatient SampleTeaching hospitalHysterectomyDatabase studyInpatient hysterectomyRobotic approachWomenHospitalDiagnosisAssociationIndicationsProfit hospitalsFactors
2019
Cardiometabolic Risk Factors and Benign Gynecologic Disorders.
AlAshqar A, Patzkowsky K, Afrin S, Wild R, Taylor HS, Borahay MA. Cardiometabolic Risk Factors and Benign Gynecologic Disorders. Obstetrical & Gynecological Survey 2019, 74: 661-673. PMID: 31755543, PMCID: PMC6986276, DOI: 10.1097/ogx.0000000000000718.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiometabolic risk factorsBenign gynecologic disordersRisk factorsUterine leiomyomaGynecologic disordersUterine leiomyoma pathogenesisBenign gynecologic conditionsPolycystic ovarian syndromeExtracellular matrix depositionCardiometabolic riskOvarian syndromeSystemic inflammationAtherosclerotic changesChronic inflammationGynecologic conditionsHyperestrogenic stateVitamin DInsulin resistanceDietary factorsCardiovascular diseasePreventive strategiesTherapeutic interventionsLeiomyoma pathogenesisClinical implicationsEndometriosisPrenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats
Mouihate A, Kalakh S, AlMutairi R, Alashqar A. Prenatal Inflammation Dampens Neurogenesis and Enhances Serotonin Transporter Expression in the Hippocampus of Adult Female Rats. Medical Principles And Practice 2019, 28: 352-360. PMID: 30884483, PMCID: PMC6639577, DOI: 10.1159/000499658.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorPrenatal LPSAdult female ratsFemale ratsHippocampal neurogenesisSERT expressionSerotonin transporterFemale offspringGestational day 15Serotonin transporter expressionOpen field testPrenatal inflammationPregnant ratsAdult neurogenesisPrenatal exposureHippocampal expressionBACKGROUND/Adult offspringDay 15LPSNeurogenesisWestern blotTransporter expressionRatsHippocampus