2023
Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications
Kurt I, Kulhan M, AlAshqar A, Borahay M. Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications. Reproductive Sciences 2023, 31: 645-660. PMID: 37907804, DOI: 10.1007/s43032-023-01386-7.Peer-Reviewed Original ResearchPreterm birthUterine fibroidsLysyl oxidaseWarrants further investigationUterine extracellular matrixCervical insufficiencyHealthy pregnancyUterine disordersUterine tissueAdvanced glycationTherapeutic implicationsTherapeutic targetPathogenic featuresSteroid hormonesNitric oxideBiomechanical strengthUterine collagenNormal biophysical propertiesFibroidsFurther investigationPentosidinePyridinolineDisordersBirthTissue integrity
2021
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†
AlAshqar A, Reschke L, Kirschen GW, Borahay MA. Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†. Biology Of Reproduction 2021, 105: 7-31. PMID: 33739368, PMCID: PMC8256101, DOI: 10.1093/biolre/ioab054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBenign gynecologic disordersRole of inflammationGynecologic disordersClinical sequelaeCardiometabolic risk factorsNF-κB inhibitorCardiometabolic medicationsInflammatory markersSystemic complicationsGynecologic malignanciesVitamin DInflammatory pathwaysLesion progressionRisk factorsCardiovascular diseaseCyclooxygenase-2Uterine leiomyomaPathophysiological perspectiveSex steroidsHormonal treatmentDiagnostic adjunctTherapeutic implicationsNumerous cytokinesImmune systemInflammation