Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Tahir U, Katz D, Avila-Pachecho J, Bick A, Pampana A, Robbins J, Yu Z, Chen Z, Benson M, Cruz D, Ngo D, Deng S, Shi X, Zheng S, Eisman A, Farrell L, Hall M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Ruberg F, Blaner W, Jain D, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Natarajan P, Gerszten R. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nature Communications 2022, 13: 4923. PMID: 35995766, PMCID: PMC9395431, DOI: 10.1038/s41467-022-32275-3.Peer-Reviewed Original ResearchMeSH KeywordsBlack PeopleCardiovascular DiseasesGenome-Wide Association StudyHumansMetabolomeMetabolomicsTandem Mass SpectrometryConceptsGenome association studiesGenomic diversityAssociation studiesWhole-genome association studiesLocus-metabolite associationsIndividuals of European ancestryIntegrative omics approachMetabolite peaksGenetic informationCardiometabolic diseasesSpecific allelesEuropean ancestryOmics approachesSickle cell diseaseMulti-ethnic cohortTransthyretin amyloidosisAncestryHereditary diseaseIdentified metabolitesCell diseaseHuman metabolismUnknown metabolitesDiversityBlack individualsJackson Heart Study