2020
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort
Ho J, Zern E, Lau E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Farrell R, Sbarbaro J, Schoenike M, Houstis N, Baggish A, Shah R, Nayor M, Malhotra R, Lewis G. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. Journal Of The American College Of Cardiology 2020, 75: 17-26. PMID: 31918830, PMCID: PMC7043927, DOI: 10.1016/j.jacc.2019.10.048.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary artery pressurePulmonary hypertensionAbnormal pulmonary artery pressureCardiac outputChronic exertional dyspneaEvent-free survivalInvasive hemodynamic monitoringPredicting clinical outcomesBurden of PHCV event-free survivalCardiopulmonary exercise testingPredicting adverse eventsTargeted therapeutic interventionsPH subtypesExertional dyspneaPrognostic implicationsClinical outcomesAdverse eventsResting pHResponse to exerciseDeath eventsFollow-upHemodynamic assessmentArterial pressure
2018
Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease
Yeh D, Schmidt A, Eisman A, Serfas J, Naqvi M, Youniss M, Ryfa A, Khan A, Safi L, Tabtabai S, Bhatt A, Lewis G. Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease. Heart 2018, 104: 2044. PMID: 30030334, DOI: 10.1136/heartjnl-2017-312572.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingRV reserveRight ventricleHeart failureNew York Heart Association classPrimary composite clinical outcomeFirst-pass radionuclide ventriculographyPrevalence of heart failureRV ejection fractionRV systolic functionEvent-free survivalMedian follow-upCongenital heart diseaseReserve groupComposite clinical outcomeAdverse cardiac outcomesTertiary care centreRight ventricular reserveAdverse cardiovascular outcomesPredicting adverse cardiovascular outcomesSystolic function assessmentRV dilatationACHD populationPrognostic impactAsymptomatic patients