2017
Cell Replacement Strategies for Parkinson’s Disease
Chatterjee D, Wakeman D, Kordower J. Cell Replacement Strategies for Parkinson’s Disease. Molecular And Translational Medicine 2017, 73-83. DOI: 10.1007/978-3-319-57153-9_4.Peer-Reviewed Original ResearchCell replacement strategiesFetal graftsClinical trialsParkinson's diseaseAnimal modelsDouble-blind clinical assessmentOpen-label clinical trialCareful subject selectionDopamine cell replacementGraft-induced dyskinesiaPotential clinical efficacyProgressive neurodegenerative disorderCell transplantation therapyPrion-like transmissionStem cellsGraft microenvironmentMotor dysfunctionMotor symptomsNigrostriatal pathwayClinical efficacyReplacement therapyDopaminergic neuronsLewy bodiesSpecific therapyCell replacement therapy
2011
Cell Transplantation and Gene Therapy in Parkinson's Disease
Wakeman D, Dodiya H, Kordower J. Cell Transplantation and Gene Therapy in Parkinson's Disease. Annals Of Global Health 2011, 78: 126-158. PMID: 21259269, DOI: 10.1002/msj.20233.Peer-Reviewed Original ResearchConceptsParkinson's diseaseLong-term disease modificationFetal dopamine neuronsGraft-induced dyskinesiaStem cell transplantationCourse of diseaseDirect cell replacementProgressive neurodegenerative disorderWidespread clinical useGene therapyPatient-derived cellsDopamine replacementMotor symptomsDisease modificationDopamine deficiencyViral vector deliveryCell transplantationSymptomatic strategiesDopamine neuronsClinical trialsEfficacy profileDopaminergic circuitryMotor neuronsClinical studiesVentral midbrain