Incorporating Individual-Level Treatment Effects and Outcome Preferences Into Personalized Blood Pressure Target Recommendations.
Ascher S, Kravitz R, Scherzer R, Berry J, de Lemos J, Estrella M, Tancredi D, Killeen A, Ix J, Shlipak M. Incorporating Individual-Level Treatment Effects and Outcome Preferences Into Personalized Blood Pressure Target Recommendations. Journal Of The American Heart Association 2024, 13: e033995. PMID: 39136305, DOI: 10.1161/jaha.124.033995.Peer-Reviewed Original ResearchNet benefitsSPRINT participantsIndividual-level treatment effectsPositive net benefitsBlood pressureIndividual treatment effectsTargeted recommendationsTreatment effectsSimulated preferencesRisk of adverse eventsAdverse eventsCognitive impairmentPreference weightsRisk differenceDecision-making frameworkAE riskPatient riskSprintSimulation benefitsParticipantsPredicted riskHigh riskCox modelBP loweringRisk