David Ganz
Staff Affiliate - OtherAbout
Research
Publications
2024
Preventing Falls in Older Persons
Reuben D, Ganz D. Preventing Falls in Older Persons. JAMA 2024, 332: 19-20. PMID: 38833266, DOI: 10.1001/jama.2024.9063.Peer-Reviewed Original ResearchAssessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study
Esserman D, Greene E, Latham N, Kane M, Lu C, Peduzzi P, Gill T, Ganz D. Assessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study. Contemporary Clinical Trials 2024, 142: 107572. PMID: 38740298, DOI: 10.1016/j.cct.2024.107572.Peer-Reviewed Original ResearchElectronic health record dataElectronic health recordsOutcome ascertainmentDevelop Confidence in EldersElectronic health record platformsClinical sitesPrimary care practicesHealth record dataMulti-site trialMulti-site clinical trialCare practicesHealth recordsAssess readinessAcute clinical outcomesHealthcare systemRecord dataClinical trialsReduce injuriesData qualityData comprehensionChecklistStudy dataClinical trial sitesVariable data qualityAscertainmentValidation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data
Ganz D, Esserman D, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Greene E. Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data. The Journals Of Gerontology Series A 2024, 79: glae096. PMID: 38566617, PMCID: PMC11167485, DOI: 10.1093/gerona/glae096.Peer-Reviewed Original ResearchFee-for-serviceFall injuriesMedicare AdvantageMedicare dataTrial armsHealthcare systemDevelop Confidence in EldersArea under the receiver operating characteristic curveMedicare fee-for-serviceStratified resultsMedicareReduce injuriesMedical attentionObservational studyStrideReceiver operating characteristic curveCalendar monthMA dataInjuryData sourcesHealthcareArmReference standardTrialsWindow size
2023
A compressed large language model embedding dataset of ICD 10 CM descriptions
Kane M, King C, Esserman D, Latham N, Greene E, Ganz D. A compressed large language model embedding dataset of ICD 10 CM descriptions. BMC Bioinformatics 2023, 24: 482. PMID: 38105180, PMCID: PMC10726612, DOI: 10.1186/s12859-023-05597-2.Peer-Reviewed Original ResearchCaring for high-need patients
Hempel S, Bolshakova M, Hochman M, Jimenez E, Thompson G, Motala A, Ganz D, Gabrielian S, Edwards S, Zenner J, Dennis B, Chang E. Caring for high-need patients. BMC Health Services Research 2023, 23: 1289. PMID: 37996845, PMCID: PMC10668484, DOI: 10.1186/s12913-023-10236-w.Peer-Reviewed Original ResearchConceptsHigh-need patientsCare professionalsNeed domainsEnvironmental scanHealth care systemRapid literature reviewTaxonomy of interventionsIndividual patientsPatientsHigh needSystematic reviewCare systemPanel meetingHealthcare practitionersIntervention TaxonomyInterventionIdentification of needsScansDelphi panelConstruct validityDownstream effectsThoughtful approachProfessionalsImplementation scientistsPotential unintended consequences
2022
World guidelines for falls prevention and management for older adults: a global initiative
Montero-Odasso M, van der Velde N, Martin F, Petrovic M, Tan M, Ryg J, Aguilar-Navarro S, Alexander N, Becker C, Blain H, Bourke R, Cameron I, Camicioli R, Clemson L, Close J, Delbaere K, Duan L, Duque G, Dyer S, Freiberger E, Ganz D, Gómez F, Hausdorff J, Hogan D, Hunter S, Jauregui J, Kamkar N, Kenny R, Lamb S, Latham N, Lipsitz L, Liu-Ambrose T, Logan P, Lord S, Mallet L, Marsh D, Milisen K, Moctezuma-Gallegos R, Morris M, Nieuwboer A, Perracini M, Pieruccini-Faria F, Pighills A, Said C, Sejdic E, Sherrington C, Skelton D, Dsouza S, Speechley M, Stark S, Todd C, Troen B, van der Cammen T, Verghese J, Vlaeyen E, Watt J, Masud T, Singh D, Aguilar-Navarro S, Caona E, Alexander N, Allen N, Anweiller C, Avila-Funes A, Santos R, Batchelor F, Becker C, Beauchamp M, Birimoglu C, Blain H, Bohlke K, Bourke R, Bouzòn C, Bridenbaugh S, Buendia P, Cameron I, Camicioli R, Canning C, Cano-Gutierrez C, Carbajal J, de Abreu D, Casas-Herrero A, Ceriani A, Cesari M, Chiari L, Clemson L, Close J, Alemǻn L, Dawson R, Delbaere K, Doody P, Dsouza S, Duan L, Duque G, Dyer S, Ellmers T, Fairhall N, Ferrucci L, Freiberger E, Frith J, Espinola H, Ganz D, Giber F, Gómez J, Gutiérrez-Robledo L, Hartikainen S, Hausdorff J, Hogan D, Wong C, Howe S, Hunter S, Jara J, Jauregui R, Jellema A, Jenni S, Jepson D, Kalula S, Kamkar N, Singh D, Kenny R, Kerse N, Kobusingye O, Kressig R, Kwok, Lamb S, Latham N, Lim M, Lipsitz L, Liu-Ambrose T, Logan P, Lord S, Lourenço R, Madden K, Mallet L, Marín-Larraín P, Marsh D, Martin F, Padilla D, Masud T, Mat S, McGarrigle L, McIlroy B, Melgar-Cuellar F, Menant J, Milisen K, Mimenza A, Moctezuma-Gallegos R, Montero-Odasso M, Morris M, Muneeb I, Negahban H, Nieuwboer A, Norris M, Ogliari G, Oliveira J, Parodi J, Perez S, Perracini M, Petrovic M, Ovares J, Pieruccini-Faria F, Pighills A, Pinheiro M, Poelgeest E, Ulate X, Robinson K, Ryg J, Said C, Sakurai R, Schapira M, Sejdic E, Seppala L, Sgaravatti A, Sherrington C, Skelton D, Song Y, Speechley M, Stark S, Sultana M, Suri A, Tan M, Taylor M, Thomsen K, Tiedemann A, Tito S, Todd C, Troen B, Van der Cammen T, Van der Velde N, Verghese J, Vlaeyen E, Watt J, Welmer A, Won C, Zijlstra G. World guidelines for falls prevention and management for older adults: a global initiative. Age And Ageing 2022, 51: afac205. PMID: 36178003, PMCID: PMC9523684, DOI: 10.1093/ageing/afac205.Peer-Reviewed Original ResearchConceptsPerspectives of older adultsFall preventionOlder adultsMultifactorial falls risk assessmentCore set of recommendationsCommunity-dwelling older adultsFall risk assessmentFall-related injuriesPerson-centred approachModified Delphi processFlexible implementation strategyHealth related costsWorking GroupMiddle-income countriesMultidisciplinary group of expertsQuality of lifeDetails of assessmentMultidomain interventionPhysical activityFall riskIntervention componentsSet of recommendationsDelphi processFunctional independenceMultidisciplinary group
2020
A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2017
Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods
Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, Peduzzi P. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. The Journals Of Gerontology Series A 2017, 73: 1053-1061. PMID: 29045582, PMCID: PMC6037050, DOI: 10.1093/gerona/glx190.Peer-Reviewed Original ResearchConceptsSerious fall injuriesInjury prevention strategiesFall injuriesPragmatic trialHealth care systemUsual carePrevention strategiesControl groupOlder adultsCare systemMultifactorial risk assessmentCommunity-living personsEnhanced usual carePrimary outcome rateIndividualized care plansPrimary care practicesTarget sample sizeEvidence-based informationSecondary outcomesPrimary outcomeOutcome ratesComanagement modelFall preventionSTRIDE studyMedical attention
2001
A novel system for in vitro maturation of human oocytes
Cekleniak N, Combelles C, Ganz D, Fung J, Albertini D, Racowsky C. A novel system for in vitro maturation of human oocytes. Fertility And Sterility 2001, 75: 1185-1193. PMID: 11384647, DOI: 10.1016/s0015-0282(01)01789-7.Peer-Reviewed Original ResearchConceptsIn vitro maturationMetaphase II oocytesMetaphase IIHuman oocytesII oocytesIn vitro maturation of human oocytesMaturation of human oocytesProportion of mature oocytesGerminal vesicle-stageCumulus-free oocytesConditional logistic regression analysisGerminal vesicle stageProgression to metaphaseLogistic regression analysisFluorescence in situ hybridizationVesicle stageGlucose-free mediumMature oocytesStage oocytesTC199OocytesImmunofluorescence analysisAligned chromosomesRegression analysisMetaphase
2000
A Novel System Which Improves In Vitro Maturation of Human Oocytes
Cekleniak N, Combelles C, Ganz D, Albertini D, Racowsky C. A Novel System Which Improves In Vitro Maturation of Human Oocytes. Fertility And Sterility 2000, 74: s32. DOI: 10.1016/s0015-0282(00)00810-4.Peer-Reviewed Original Research