2022
Moving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease
Tuttle KR, Wong L, St. Peter W, Roberts G, Rangaswami J, Mottl A, Kliger A, Harris RC, Gee PO, Fowler K, Cherney D, Brosius FC, Argyropoulos C, Quaggin SE. Moving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1092-1103. PMID: 35649722, PMCID: PMC9269635, DOI: 10.2215/cjn.02980322.Commentaries, Editorials and LettersConceptsDiabetic kidney diseaseKidney disease careKidney diseaseHealth care systemDisease careKidney failureGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsAngiotensin-converting enzyme inhibitorBreakthrough therapiesMajor public health challengeHealth care system supportCare systemAngiotensin receptor blockersCotransporter 2 inhibitorsHalf of patientsPocket drug costsIndividual health care systemsPublic health challengeHealth care professionalsValue-based careEligible patientsMineralocorticoid antagonistsCardiovascular events
2021
Transforming the Care of Patients with Diabetic Kidney Disease
Brosius FC, Cherney D, Gee PO, Harris RC, Kliger A, Tuttle KR, Quaggin SE. Transforming the Care of Patients with Diabetic Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2021, 16: 1590-1600. PMID: 34103350, PMCID: PMC8499007, DOI: 10.2215/cjn.18641120.Commentaries, Editorials and LettersConceptsRenin-angiotensin system inhibitorsDiabetic kidney diseaseIrbesartan Diabetic Nephropathy TrialCare of patientsKidney diseaseSystem inhibitorsNew therapiesAngiotensin II Antagonist Losartan (RENAAL) trialAngiotensin II type 1 receptor blockerDiabetic kidney disease progressionType 1 receptor blockerCardiovascular protective therapiesReduction of EndpointsKidney disease progressionKidney protective effectsRenin-angiotensin systemDiabetic Nephropathy TrialRisk of deathHigh residual riskHealth care providersPowerful new therapiesNephropathy TrialReceptor blockersDevastating complicationAntihypertensive agents
2010
In-Center Hemodialysis Six Times per Week versus Three Times per Week
Chertow G, Levin N, Beck G, Depner T, Eggers P, Gassman J, Gorodetskaya I, Greene T, James S, Larive B, Lindsay R, Mehta R, Miller B, Ornt D, Rajagopalan S, Rastogi A, Rocco M, Schiller B, Sergeyeva O, Schulman G, Ting G, Unruh M, Star R, Kliger A. In-Center Hemodialysis Six Times per Week versus Three Times per Week. New England Journal Of Medicine 2010, 363: 2287-2300. PMID: 21091062, PMCID: PMC3042140, DOI: 10.1056/nejmoa1001593.Peer-Reviewed Original ResearchConceptsLeft ventricular massPhysical health composite scoresFrequent hemodialysisComposite outcomeVascular accessVentricular massSelf-reported depressionConventional hemodialysisCardiac magnetic resonance imagingConventional hemodialysis groupErythropoiesis-stimulating agentsRate of hospitalizationSerum albumin concentrationComposite scoreSelf-reported physical healthCognitive performanceMagnetic resonance imagingMaintenance hemodialysisSecondary outcomesBlood pressureLaboratory markersCenter hemodialysisClinical trialsMineral metabolismHealth Survey
2001
PARAMETERS OF HIGH BONE-TURNOVER PREDICT BONE LOSS IN RENAL TRANSPLANT PATIENTS: A LONGITUDINAL STUDY1,2
Cruz D, Wysolmerski J, Brickel H, Gundberg C, Simpson C, Mitnick M, Kliger A, Lorber M, Basadonna G, Friedman A, Insogna K, Bia M. PARAMETERS OF HIGH BONE-TURNOVER PREDICT BONE LOSS IN RENAL TRANSPLANT PATIENTS: A LONGITUDINAL STUDY1,2. Transplantation 2001, 72: 83-88. PMID: 11468539, DOI: 10.1097/00007890-200107150-00017.Peer-Reviewed Original ResearchConceptsBone mineral densityPosttransplant bone lossRenal transplant recipientsLong-term renal transplant recipientsDual-energy X-ray absorptiometryRenal transplant patientsBone lossTransplant recipientsBone resorptionBiochemical markersTransplant patientsLumbar spineLong-term renal transplant patientsEnergy X-ray absorptiometryAccelerated bone resorptionElevated urinary levelsUse of cyclosporineElevated biochemical markersPrevious cross-sectional studiesCross-sectional studyX-ray absorptiometryStable bone massPostrenal transplantationAntiresorptive therapyKidney transplantationIdentification and treatment of depression in a cohort of patients maintained on chronic peritoneal dialysis
Wuerth D, Finkelstein S, Ciarcia J, Peterson R, Kliger A, Finkelstein F. Identification and treatment of depression in a cohort of patients maintained on chronic peritoneal dialysis. American Journal Of Kidney Diseases 2001, 37: 1011-1017. PMID: 11325684, DOI: 10.1016/s0272-6386(05)80018-6.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseChronic peritoneal dialysisBeck Depression InventoryAntidepressant medicationClinical depressionPsychiatric interviewerPeritoneal dialysisBDI scoresFurther evaluationMortality of patientsCohort of patientsHamilton Depression ScaleTreatment of depressionSelf-administered questionnaireRenal diseasePatient populationDepression ScaleLarge cohortPsychiatric interviewPatientsPossible therapyMedicationsDepression InventoryPilot studyTherapyPatient Safety in End-Stage Renal Disease: How Do We Create a Safe Environment?
Kliger A, Diamond L. Patient Safety in End-Stage Renal Disease: How Do We Create a Safe Environment? Advances In Kidney Disease And Health 2001, 8: 131-137. PMID: 11349254, DOI: 10.1053/jarr.2001.23991.Commentaries, Editorials and LettersContinuous peritoneal dialysis and the extended care facility
Carey H, Chorney W, Pherson K, Finkelstein F, Kliger A. Continuous peritoneal dialysis and the extended care facility. American Journal Of Kidney Diseases 2001, 37: 580-587. PMID: 11228183, DOI: 10.1053/ajkd.2001.22084.Peer-Reviewed Original ResearchConceptsContinuous peritoneal dialysisExtended care facilitiesPeritoneal dialysisCare facilitiesEnd-stage renal diseaseLong-term patient managementPeritoneal dialysis nursesElderly patientsPeritonitis rateTechnique failureRenal diseaseDialysis nursesNephrology staffPatient managementOutcome measuresNursing homesGeriatric facilitiesPatientsDisproportionate increaseDialysisCareHospitalizationTherapyEducation programsMortality
2000
Chronic renal insufficiency: Current understandings and their implications
Bolton W, Kliger A. Chronic renal insufficiency: Current understandings and their implications. American Journal Of Kidney Diseases 2000, 36: s4-s12. PMID: 11118153, DOI: 10.1053/ajkd.2000.19926.Commentaries, Editorials and LettersConceptsChronic renal insufficiencyHealthy People 2010Kidney diseaseComorbid conditionsRenal replacement therapyChronic kidney diseaseCare of patientsClear diagnostic criteriaPopulation-based surveyAvailable epidemiologic dataHealth care resourcesPractical screening testHealth care systemExpeditious referralRenal dysfunctionRenal insufficiencyUremic complicationsCreatinine levelsKidney failureReplacement therapyAppropriate referralBlack raceOptimal careSpecialty careMale genderPOSTTRANSPLANT BONE DISEASE: EVIDENCE FOR A HIGH BONE RESORPTION STATE
Cayco A, Wysolmerski J, Simpson C, Mitnick M, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M. POSTTRANSPLANT BONE DISEASE: EVIDENCE FOR A HIGH BONE RESORPTION STATE. Transplantation 2000, 70: 1722-1728. PMID: 11152104, DOI: 10.1097/00007890-200012270-00011.Peer-Reviewed Original ResearchConceptsLong-term renal transplant recipientsRenal transplant recipientsBone mineral densityTransplant recipientsBone lossBone resorptionFirst post-transplant yearCumulative prednisone doseElevated urinary levelsIntact parathyroid hormonePercent of patientsDuration of dialysisPost-transplant yearPrevalence of osteoporosisCross-sectional studyLoss of boneBone resorption statePrednisone doseYear posttransplantIntact PTHRenal transplantLevels of calciumRenal functionSerum levelsTransplant yearIncidence of Peritonitis in Chronic Peritoneal Dialysis Patients Infused with Intravenous Iron Dextran
Allen J, Troidle L, Juergensen P, Kliger A, Finkelstein F. Incidence of Peritonitis in Chronic Peritoneal Dialysis Patients Infused with Intravenous Iron Dextran. Advances In Peritoneal Dialysis 2000, 20: 674-678. PMID: 11216558, DOI: 10.1177/089686080002000616.Peer-Reviewed Original ResearchConceptsChronic peritoneal dialysis patientsPeritoneal dialysis patientsPeritonitis episodesCPD patientsIron therapyDialysis patientsStudy populationEnd-stage renal disease patientsDialysis Outcomes Quality Initiative guidelinesIntravenous iron-dextran therapyIntravenous iron dextranIncidence of peritonitisOral iron therapyRisk of peritonitisQuality Initiative guidelinesRenal disease patientsEpisodes of peritonitisIron replacement therapyOutpatient hospital settingIron dextran therapyTransferrin saturation levelsCause of deathNumber of episodesRisk of infectionSpectrum of organismsResidual Renal Function in a Large Cohort of Peritoneal Dialysis Patients: Change over Time, Impact on Mortality and Nutrition
Shemin D, Bostom A, Lambert C, Hill C, Kitsen J, Kliger A. Residual Renal Function in a Large Cohort of Peritoneal Dialysis Patients: Change over Time, Impact on Mortality and Nutrition. Advances In Peritoneal Dialysis 2000, 20: 439-444. PMID: 11007376, DOI: 10.1177/089686080002000411.Peer-Reviewed Original ResearchConceptsWeekly renal Kt/VRenal Kt/VResidual renal functionSerum albumin levelRenal creatinine clearanceKt/VKt/V ureaPeritoneal dialysis patientsCreatinine clearanceRenal functionPD patientsAlbumin levelsSolute clearanceDialysis patientsRenal clearanceTotal Kt/V ureaNutritional statusMean serum albumin levelTotal creatinine clearanceGood nutritional statusDiabetic statusCCR groupDialysis unitsLarge cohortPatientsTidal peritoneal dialysis: Comparison of different tidal regimens and automated peritoneal dialysis
Juergensen P, Murphy A, Pherson K, Kliger A, Finkelstein F. Tidal peritoneal dialysis: Comparison of different tidal regimens and automated peritoneal dialysis. Kidney International 2000, 57: 2603-2607. PMID: 10844630, DOI: 10.1046/j.1523-1755.2000.00120.x.Peer-Reviewed Original ResearchConceptsTidal peritoneal dialysisPKt/VContinuous ambulatory peritoneal dialysisGroup I patientsGroup II patientsDuration of therapyPeritoneal dialysis patientsPeritoneal dialysisDialysis patientsI patientsII patientsDialysis unitsNational Kidney Foundation-Dialysis Outcomes Quality Initiative (NKF-DOQI) Clinical Practice GuidelinesSeparate daysDialysis solutionResidual renal function declinesPD solutionsDialysate volumeWeekly Kt/VPeritoneal dialysis clearanceRenal function declineAmbulatory peritoneal dialysisClinical practice guidelinesKt/VDialysis clearanceAutomated Peritoneal Dialysis: Clinical Prescription and Technology
Ronco C, Kliger A, Amici G, Virga G. Automated Peritoneal Dialysis: Clinical Prescription and Technology. Advances In Peritoneal Dialysis 2000, 20: 70-76. PMID: 10911647, DOI: 10.1177/089686080002002s14.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPatient assessment of quality of care in a chronic peritoneal dialysis facility
Wuerth D, Finkelstein S, Kliger A, Finkelstein F. Patient assessment of quality of care in a chronic peritoneal dialysis facility. American Journal Of Kidney Diseases 2000, 35: 638-643. PMID: 10739784, DOI: 10.1016/s0272-6386(00)70010-2.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseChronic peritoneal dialysisPercentage of patientsPatient satisfactionPatients' perceptionsDialysis facilitiesPeritoneal dialysisPatient responseExit-site infectionPeritoneal dialysis programPhysician-patient interactionNurse-patient interactionLong-term acceptanceCPD therapyCPD patientsRenal diseasePatient assessmentPresent studyDialysis programPrimary nurseDialysis unitsPatientsPsychosocial stressAreas of satisfactionAreas of dissatisfaction
1999
Challenges of Managing Chronic Peritoneal Dialysis-Associated Peritonitis
Troidle L, Kliger A, Finkelstein F. Challenges of Managing Chronic Peritoneal Dialysis-Associated Peritonitis. Advances In Peritoneal Dialysis 1999, 19: 315-318. PMID: 10507811, DOI: 10.1177/089686089901900406.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEffect of Duration of Chronic Peritoneal Dialysis Therapy on the Development of Peritonitis
Troidle L, Gorban–Brennan N, Kliger A, Finkelstein F. Effect of Duration of Chronic Peritoneal Dialysis Therapy on the Development of Peritonitis. Advances In Peritoneal Dialysis 1999, 19: 376-379. PMID: 10507821, DOI: 10.1177/089686089901900416.Peer-Reviewed Original ResearchConceptsDevelopment of peritonitisChronic peritoneal dialysis therapyCPD therapyGroup of patientsPeritoneal dialysis therapyGroup 1Group 3Group 2Dialysis therapyStudy periodCharts of patientsPeripheral vascular diseaseEpisodes of peritonitisOnset of peritonitisCoronary artery diseaseIncidence of deathRate of peritonitisOut-patient unitPeritoneal macrophage functionStaphylococcus aureus peritonitisPeritoneal membrane structureSpectrum of organismsArtery diseaseDiabetes mellitusRetrospective reviewValue of scintigraphy in chronic peritoneal dialysis patients
Juergensen P, Rizvi H, Caride V, Kliger A, Finkelstein F. Value of scintigraphy in chronic peritoneal dialysis patients. Kidney International 1999, 55: 1111-1119. PMID: 10027951, DOI: 10.1046/j.1523-1755.1999.0550031111.x.Peer-Reviewed Original ResearchConceptsChronic peritoneal dialysisCPD patientsPeritoneal scintigraphyAbdominal wallDextrose peritoneal dialysis solutionEffective renal replacement therapyEnd-stage renal diseaseChronic peritoneal dialysis patientsGenital swellingPeritoneal fluid leaksRenal replacement therapyCatheter-related problemsPeritoneal dialysis patientsValue of scintigraphyPeritoneal dialysis solutionPleural fluid collectionsLoss of ultrafiltrationPeritoneal locationTemporary discontinuationDialysis patientsRenal diseaseScintigraphy scanPeritoneal dialysisReplacement therapyScintigraphic evidence
1996
Nine episodes of CPD-associated peritonitis with vancomycin resistant enterococci
Troidle L, Kliger A, Gorban-Brennan N, Fikrig M, Golden M, Finkelstein F. Nine episodes of CPD-associated peritonitis with vancomycin resistant enterococci. Kidney International 1996, 50: 1368-1372. PMID: 8887301, DOI: 10.1038/ki.1996.451.Peer-Reviewed Case Reports and Technical NotesConceptsVancomycin-resistant enterococciCPD therapyResistant enterococciChronic peritoneal dialysisEpisodes of peritonitisCephalosporin therapyPatient monthsTenckhoff catheterCPD patientsDiabetes mellitusOptimal therapyPeritoneal dialysisMean ageAntimicrobial therapyVRE carriageCardiovascular diseaseDialysis unitsGastrointestinal diseasesCertain demographic dataPeritonitisCase controlPatientsDemographic dataTherapyCatheterContinuous Peritoneal Dialysis-Associated Peritonitis of Nosocomial Origin
Troidle L, Kliger A, Goldie S, Gorban-Brennan N, Brown E, Fikrig M, Finkelstein F. Continuous Peritoneal Dialysis-Associated Peritonitis of Nosocomial Origin. Advances In Peritoneal Dialysis 1996, 16: 505-510. PMID: 8914180, DOI: 10.1177/089686089601600513.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAge FactorsAgedAnti-Bacterial AgentsCardiovascular DiseasesComorbidityConnecticutCross InfectionDiabetes MellitusDrug Resistance, MicrobialEnterococcusFemaleGastrointestinal DiseasesGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHIV SeropositivityHospitalizationHumansIncidenceLength of StayMaleMiddle AgedPatient AdmissionPeripheral Vascular DiseasesPeritoneal Dialysis, Continuous AmbulatoryPeritonitisRetrospective StudiesRisk FactorsSerum AlbuminStaphylococcal InfectionsTreatment OutcomeVancomycinConceptsAcute care hospitalsNosocomial peritonitisCPD patientsSpectrum of organismsCPD therapyInvasive proceduresHuman immunodeficiency virus seropositivityPeritoneal Dialysis-Associated PeritonitisAntecedent antibiotic usePeripheral vascular diseaseContinuous peritoneal dialysisMean serum albuminStandard antibiotic therapyPossible risk factorsAntecedent antibioticsHospital stayComorbid diseasesNineteen patientsRenal functionStrains of EnterococcusAntibiotic therapyRetrospective reviewNP patientsPeritoneal dialysisVirus seropositivityThe Incident Patient Cohort Study Design With Uncontrolled Dose
GOTCH F, GENTILE D, KEEN M, AMERLING R, FOLKERT V, KLIGER A, SHAPIRO W. The Incident Patient Cohort Study Design With Uncontrolled Dose. ASAIO Journal 1996, 42: m514-517. PMID: 8944932, DOI: 10.1097/00002480-199609000-00039.Peer-Reviewed Original ResearchConceptsPeritoneal dialysisContinuous ambulatory peritoneal dialysisAmbulatory peritoneal dialysisCohort study designClinical outcome studiesRenal urea clearanceDialysis prescriptionSingle dosesDose equivalencyRelative riskDialysis doseMortality riskOutcome studiesDose levelsUrea clearanceStudy designMonth intervalsD responseHemodialysisDialysisDoseDosesRiskMortalityWide variance