2022
A randomized controlled pilot trial of anakinra for hemodialysis inflammation
Dember L, Hung A, Mehrotra R, Hsu J, Raj D, Charytan D, Mc Causland F, Regunathan-Shenk R, Landis J, Kimmel P, Kliger A, Himmelfarb J, Ikizler T, Consortium H. A randomized controlled pilot trial of anakinra for hemodialysis inflammation. Kidney International 2022, 102: 1178-1187. PMID: 35863559, PMCID: PMC9588554, DOI: 10.1016/j.kint.2022.06.022.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesPlacebo groupAdverse eventsMedian decreaseHemodialysis patientsIL-6IL-1 receptor antagonistRate of adverse eventsEffect of anakinraPlacebo-controlled trialBaseline to weekAnti-cytokine therapyIL-1 inhibitionAssociated with morbidityAnakinra groupReceptor antagonistBetween-group differencesEfficacy outcomesAnakinraMaintenance hemodialysisRandomized controlled pilot trialChronic inflammationEvaluate safetyPlaceboIL-1
2020
Combination Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD (HIDE): A Randomized, Placebo-Controlled, Pilot Trial.
Charytan D, Hsu J, Mc Causland F, Waikar S, Ikizler T, Raj D, Landis J, Mehrotra R, Williams M, DiCarli M, Skali H, Kimmel P, Kliger A, Dember L, Himmelfarb J, Anderson A, Hung A, Sharma S, Weiner D. Combination Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD (HIDE): A Randomized, Placebo-Controlled, Pilot Trial. Kidney360 2020, 1: 1380-1389. PMID: 35372900, PMCID: PMC8815530, DOI: 10.34067/kid.0004342020.Peer-Reviewed Original ResearchMeSH KeywordsHumansHydralazineIsosorbide DinitrateKidney Failure, ChronicPilot ProjectsRenal DialysisTomography, X-Ray ComputedConceptsIsosorbide dinitrateCoronary flow reserveAdverse eventsMaintenance HDMitral annular e' velocityDouble-blind pilot trialFlow reserveRecurrent intradialytic hypotensionRandomized to placeboMaximum tolerated doseTissue Doppler echocardiographyParticipants discontinued therapyGastrointestinal side effectsDetect between-group differencesPilot trialIntra-dialytic hypotensionPlacebo-ControlledPositron emission tomographyDose escalationHeart failure mortalityDose reductionStudy medicationTolerated dosePlacebo groupCombination therapy
2001
Identification and treatment of depression in a cohort of patients maintained on chronic peritoneal dialysis
Wuerth D, Finkelstein S, Ciarcia J, Peterson R, Kliger A, Finkelstein F. Identification and treatment of depression in a cohort of patients maintained on chronic peritoneal dialysis. American Journal Of Kidney Diseases 2001, 37: 1011-1017. PMID: 11325684, DOI: 10.1016/s0272-6386(05)80018-6.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseChronic peritoneal dialysisBeck Depression InventoryAntidepressant medicationClinical depressionPsychiatric interviewerPeritoneal dialysisBDI scoresFurther evaluationMortality of patientsCohort of patientsHamilton Depression ScaleTreatment of depressionSelf-administered questionnaireRenal diseasePatient populationDepression ScaleLarge cohortPsychiatric interviewPatientsPossible therapyMedicationsDepression InventoryPilot studyTherapy