2024
Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase
Merali C, Quinn C, Huffman K, Pieper C, Bogan J, Barrero C, Merali S. Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase. Obesity 2024 PMID: 39420421, DOI: 10.1002/oby.24150.Peer-Reviewed Original ResearchMolecular mechanismsIncreased GLUT4 translocationComplex molecular mechanismsGlucose uptake regulationUBX domainIncreased glucose uptakeGLUT4 translocationGLUT4 functionCaloric restrictionPTGIS expressionProteomic profilingCell surfaceCleavage pathwayInsulin sensitivityHuman adipocytesAdipose tissueGlucose uptakeGLUT4Enhanced insulin sensitivityInsulin receptor densityInsulin actionRisk of metabolic disordersCell membraneProstacyclin synthaseMonths of CR
2019
Vasopressin inactivation: Role of insulin-regulated aminopeptidase
Li DT, Habtemichael EN, Bogan JS. Vasopressin inactivation: Role of insulin-regulated aminopeptidase. Vitamins & Hormones 2019, 113: 101-128. PMID: 32138946, DOI: 10.1016/bs.vh.2019.08.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInsulin-regulated aminopeptidaseInsulin-responsive glucose transporterHuman placental leucine aminopeptidaseMetabolic syndromeInsulin resistanceVasopressin secretionUBX domainCoordinated regulationGenetic variationAbsence of insulinGLUT4 proteinGestational diabetes insipidusPotential pathophysiologic rolePhysiological importanceGlucose transporterCell surfaceProteolytic cleavageNovel insightsPlacental leucine aminopeptidaseRodent homologueVasopressinase activityLeucine aminopeptidasePathophysiologic mechanismsMuscle cellsPathophysiologic role
2011
The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment*
Orme CM, Bogan JS. The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment*. Journal Of Biological Chemistry 2011, 287: 6679-6692. PMID: 22207755, PMCID: PMC3307297, DOI: 10.1074/jbc.m111.284232.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesBiological TransportCell Cycle ProteinsEndoplasmic ReticulumGene ExpressionGene Knockdown TechniquesGolgi ApparatusHEK293 CellsHeLa CellsHumansIntracellular Signaling Peptides and ProteinsOncogene Proteins, FusionProtein Structure, QuaternaryProtein Structure, TertiaryProtein TransportUbiquitinValosin Containing ProteinConceptsUBX domainIntermediate compartmentEndoplasmic reticulum-Golgi intermediate compartmentEndoplasmic reticulum exit sitesEarly secretory pathwayGolgi intermediate compartmentATP-bound stateP97/VCPN-terminal domainN-terminal regionP97 hexamerUbiquitylated proteinsHexameric ATPaseUbiquitylated substratesP97 activityCellular processesSecretory pathwayOligomeric statusMembrane fusionC-terminusGolgi complexEndoplasmic reticulumHEK293 cellsCell typesHeLa cells