2014
Improved repair of dermal wounds in mice lacking microRNA‐155
van Solingen C, Araldi E, Chamorro‐Jorganes A, Fernández‐Hernando C, Suárez Y. Improved repair of dermal wounds in mice lacking microRNA‐155. Journal Of Cellular And Molecular Medicine 2014, 18: 1104-1112. PMID: 24636235, PMCID: PMC4112003, DOI: 10.1111/jcmm.12255.Peer-Reviewed Original ResearchConceptsMiR-155Wound tissueWound healingIncreased expressionWound closureImpaired wound repairAnalysis of woundsSkin of miceMiR-155 targetsType 1 collagenWild-type animalsInflammatory mediatorsWT miceWound healing processImmune responseInterleukin-4Healthy skinMicroRNA-155Punch woundsMiceElevated numbersBeneficial effectsWound closingDermal wound healingDermal wounds
2009
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC. Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17511-17516. PMID: 19805174, PMCID: PMC2762666, DOI: 10.1073/pnas.0907359106.Peer-Reviewed Original ResearchConceptsBlood vessel assemblyBone marrow-derived macrophagesBone marrow reconstitution experimentsMarrow-derived macrophagesRac activationBlood vessel formationGene expressionReconstitution experimentsMacrophage infiltrationInflammatory gene expressionVessel formationBlood flow recoveryMacrophage-mediated inflammationTissue repairMyeloid cellsBlood flow controlVessel assemblyLimb ischemiaFunctional recoveryInflammatory responseReticulon 4BWound healingIschemiaFlow recoveryGenes