2020
ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis.
Fernández-Hernando C, Suárez Y. ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis. Current Opinion In Hematology 2020, 27: 206-213. PMID: 32205586, PMCID: PMC9013473, DOI: 10.1097/moh.0000000000000580.Peer-Reviewed Original ResearchConceptsStem cell regulationPotential therapeutic targetLipid metabolismCell-specific functionsSpecific molecular eventsNonmetabolic functionsRegulatory circuitsMultifunctional proteinTherapeutic targetUnanticipated roleInvolvement of ANGPTL4Molecular eventsCell regulationPhysiological roleTherapeutic applicationsPredominant expressionVascular biologyPotential therapeutic applicationsVascular homeostasisPathophysiological conditionsDifferent disease settingsANGPTL4MetabolismFirst discoveryBiological effects
2018
MicroRNAs in endothelial cell homeostasis and vascular disease
Fernández-Hernando C, Suárez Y. MicroRNAs in endothelial cell homeostasis and vascular disease. Current Opinion In Hematology 2018, 25: 227-236. PMID: 29547400, PMCID: PMC6175704, DOI: 10.1097/moh.0000000000000424.Peer-Reviewed Original ResearchConceptsVascular diseaseVascular disease preventionPotential therapeutic targetEndothelial cell homeostasisEndothelial cell functionEndothelial dysfunctionEndothelial functionVascular dysfunctionTherapeutic applicationsPotential therapeutic applicationsInvolvement of miRNAsDysregulation of miRNAsEndothelial homeostasisTherapeutic targetDisease preventionDiseaseCell functionRegulatory circuitsCritical modulatorUnanticipated roleTarget genesCell homeostasisDysfunctionMiRNAsHomeostasis
2016
MicroRNAs as regulators of endothelial cell functions in cardiometabolic diseases
Araldi E, Suárez Y. MicroRNAs as regulators of endothelial cell functions in cardiometabolic diseases. Biochimica Et Biophysica Acta 2016, 1861: 2094-2103. PMID: 26825686, PMCID: PMC5039046, DOI: 10.1016/j.bbalip.2016.01.013.Peer-Reviewed Original ResearchConceptsSmall non-coding RNAsLipid/energy metabolismCarlos Fernández-HernandoRegulation of ECNon-coding RNAsRole of miRNAsEndothelial cellsYajaira SuárezTissue homeostasisCell deathEndothelial cell functionEnvironmental stimuliEnergy metabolismMicroRNAsCell proliferationImportant functionsPotential therapeutic applicationsCell functionMiRNAsDifferent cardiometabolic diseasesMetabolic imbalanceEC dysfunctionTherapeutic applicationsPresent reviewRelated diseases
2015
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernandez-Hernando C, Suarez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Current Vascular Pharmacology 2015, 13: 291-304. PMID: 26156264, DOI: 10.2174/15701611113119990012.Peer-Reviewed Original ResearchConceptsPost-transcriptional levelMonocyte-derived phagocytesFoam cell formationGene regulatorsCell adhesion moleculeModulating microRNAsVascular smooth muscle cellsCell differentiationArterial tree resultsVascular diseaseCell formationMicroRNAsSmooth muscle cellsCap formationVascular cellsFibrous cap formationPotential therapeutic applicationsUnstable fibrous capUnstable coronary syndromesAtherosclerotic vascular diseaseTree resultsMuscle cellsChronic inflammatory diseaseProgression of atherosclerosisLesion-prone sites
2013
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernández-Hernando C, Suárez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Current Vascular Pharmacology 2013 PMID: 23713860, PMCID: PMC3883893.Peer-Reviewed Original ResearchPost-transcriptional levelMonocyte-derived phagocytesFoam cell formationGene regulatorsCell adhesion moleculeModulating microRNAsVascular smooth muscle cellsCell differentiationArterial tree resultsVascular diseaseCell formationMicroRNAsSmooth muscle cellsCap formationVascular cellsFibrous cap formationPotential therapeutic applicationsUnstable fibrous capUnstable coronary syndromesAtherosclerotic vascular diseaseTree resultsMuscle cellsChronic inflammatory diseaseProgression of atherosclerosisLesion-prone sites
2009
MicroRNAs As Novel Regulators of Angiogenesis
Suárez Y, Sessa WC. MicroRNAs As Novel Regulators of Angiogenesis. Circulation Research 2009, 104: 442-454. PMID: 19246688, PMCID: PMC2760389, DOI: 10.1161/circresaha.108.191270.Peer-Reviewed Original ResearchConceptsInvolvement of miRNAsShort noncoding RNAsPosttranscriptional regulationNoncoding RNAsNovel regulatorKey regulatorNegative regulatorGene expressionAspects of developmentNew blood vesselsRegulatorVascular biologyCurrent experimental evidencePotential therapeutic applicationsMiRNAsMicroRNAsAngiogenic processEndothelial cellsRegulationAbnormal angiogenesisTherapeutic applicationsAngiogenesisRNABiologyHomeostasis