2019
Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response
Sahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. Journal Of Clinical Investigation 2019, 129: 5518-5536. PMID: 31710308, PMCID: PMC6877327, DOI: 10.1172/jci127125.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesMiR-21 expressionTumor growthMiR-21Immune responseCytotoxic T cell responsesC motif chemokine 10Antitumor immune responseT cell responsesAntitumoral immune responseTumor immune infiltratesInduction of cytokinesPotential therapeutic implicationsMiR-21 inhibitionStages of carcinogenesisAngiostatic phenotypeTumor cell deathIL-12Immune infiltratesTherapeutic implicationsSolid tumorsTumor neovascularizationTumor progressionTumor microenvironmentTumor pathogenesis
2000
Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells
Montero M, Hernández O, Suárez Y, Matilla J, Ferruelo A, Martı́nez-Botas J, Gómez-Coronado D, Lasunción M. Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells. Atherosclerosis 2000, 153: 303-313. PMID: 11164419, DOI: 10.1016/s0021-9150(00)00417-2.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsMononuclear cellsHuman peripheral blood mononuclear cellsTh1 cytokine releaseTh2 cytokine releaseTh1/Th2Blood mononuclear cellsEffect of fluvastatinCaspase-1 activationCaspase-1 activityLate atherosclerotic lesionsTh1 responseIL-10Fluvastatin treatmentIL-12IL-18Exerts actionsCytokine releaseIL-4Cholesterol levelsT cellsAtherosclerotic lesionsImmune functionStatinsCaspase-1